Quinolones in urology

Abstract

The new quinolones have broad antimicrobial spectra covering all aerobic gram-negative and gram-positive bacteria encountered in urinary tract infections. All are administered orally, some also parenterally, low degree of resistance, few side effects and bacteriological and clinical cure rates similar to or higher than traditional antimicrobials make them especially suitable for treatment of complicated urinary tract infections including bacterial prostatitis. Non-critical use of quinolones in simple infections where standard drugs may be equally effective and safe should be discouraged.

Timing, dosing and duration of antimicrobial prophylaxis in urology: A study in guinea pigs with special reference to high-risk conditions

“…This may be for two reasons. First, the minimal inhibitory concentration of ciprofloxacin against most pathogens encountered in urologic surgery is very low [10]. Second, like all other substances that are excreted renally, ciprofloxacin reaches exceedingly high urine concentrations [11].…”