Quinolinyl-pyrazoles: synthesis and pharmacological evolution in the recent decennial

Quinoline derivatives volunteering against antimicrobial resistance: rational approaches, design strategies, structure activity relationship and mechanistic insights

“…Quinoline nucleus was first isolated from coal tar by a German chemist Friedlieb Ferdinand Runge in 1834. But later it was isolated from quinine, strychnine, cinchonine by dry distillation, by a French Chemist Charles Gerhardt and then it was widely synthesized in labs from anilines, acylaminoacetophenone, β-ketoanalide and isatin, to get differentially substituted derivatives of quinoline [ 13 ].…”

A New Series of 1,3,4-Oxadiazole Linked Quinolinyl-Pyrazole/Isoxazole Derivatives: Synthesis and Biological Activity Evaluation

“…Combination of quinoline and pyrazole structural blocks in molecules makes pharmacophores with respect to anti-cancer, interleukin, A3 adenosine receptor antagonists, anti-ulcer, and anti-inflammatory to be of certain potential [ 7 ]. Similarly, combination of quinoline and isoxazole heterocycles can result in formation of anti-TB [ 8 , 9 ], cytotoxic [ 10 ], antibacterial, antifungal [ 11 ], anti-inflammatory, and analgesic [ 12 ] compounds.…”