Quinolines derivatives as novel sunscreening agents

Polonini, Hudson; Dias, Rafael M. P.; Souza, Isabela O.; Gonçalves, Karla Mara; Gomes, Tiago B.B.; Raposo, Nádia Rezende Barbosa; Silva, Adilson David da

doi:10.1016/j.bmcl.2013.06.046

Cited by 11 publications

(7 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[15][16][17] All four species presented considerable protection, both for UVB and UVA radiations, being L. brasiliensis the one that presented the higher protection for both parameters ( Table 1 and Figure 1). Yet, it is advisable that the UVAPF should be at least 1/3 of the SPF.…”

Section: Resultsmentioning

confidence: 99%

Assessment of the Photoprotective Activity of Lippia Species from Brazil and Their use as Single UV Filters in Sunscreens

Gonçalves¹,

Polonini²,

Viccini³

et al. 2015

JYP

Self Cite

View full text Add to dashboard Cite

Objective: The present in vitro study aimed to evaluate the photoprotective activity of four plant species from Brazil. Material and Methods: Plants (Lippia brasiliensis, L. pseudothea, L. rotundifolia and L. rubella) were collected in Minas Gerais state, Brazil, and ethanolic extracts were obtained. These were incorporated in neutral lotions and their SPF, UVAPF, UVA/ UVB Ratio and Critical Wavelength were determined by diffuse transmittance spectroscopy. Results: The best results were obtained with L. brasiliensis. It was demonstrated that this species generated an estimated in vitro SPF of 9 ± 1.0, and an effective UVAPF of 8 ± 0.7, at 15% in a neutral lotion. Conclusion: Broad spectrum sunscreens were obtained when all of four species were used as single UV filter in the sunscreens formulations, although L. brasiliensis presented the best UVA/UVB balance.

show abstract

Section: Resultsmentioning

confidence: 99%

Assessment of the Photoprotective Activity of Lippia Species from Brazil and Their use as Single UV Filters in Sunscreens

Gonçalves¹,

Polonini²,

Viccini³

et al. 2015

JYP

Self Cite

View full text Add to dashboard Cite

show abstract

“…Other potential synthetic UV filters with different scaffolds have been described, namely those with heterocyclic rings, such as the new UV absorbers 167 – 178 based on quinoline derivatives with SPF and λ c values between 2 and 11 and 376 and 388 nm, respectively, being the quinoline derivative 176 considered as the most promising compound with the highest SPF value [ 143 ]. ( E , Z )-2-ethylhexyl-2-cyano-3-(furan-2-yl)acrylate ( 179 ) has also been described for its good capacity to absorb UVA radiation (λ max = 339 nm) and good solubility in oils for the formulation [ 144 ].…”

Section: Prospectsmentioning

confidence: 99%

UV Filters: Challenges and Prospects

et al. 2022

View full text Add to dashboard Cite

The use of sunscreens is an established and recommended practice to protect skin from solar-induced damage. Around 30 UV filters can be used in sunscreen products in the European Union, which ought to follow the requirements of the regulation 1223/2009 to ensure their efficacy and safety for humans. Nevertheless, low photostability and putative toxicity for humans and environment have been reported for some UV filters. Particularly, the negative impact in marine organisms has recently raised concern on the scientific community. Therefore, it is important to develop new UV filters with improved safety profile and photostability. Over the last two decades, nearly 200 new compounds have revealed promising photoprotection properties. The explored compounds were obtained through different approaches, including exploration of natural sources, synthetic pathways, and nanotechnology. Almost 50 natural products and around 140 synthetic derivatives, such as benzimidazoles, benzotriazoles, hydroxycinnamic acids, xanthones, triazines, among others, have been studied aiming the discovery of novel, effective, and safer future photoprotective agents. Herein, we provide the reader with an overview about UV filters’ challenges and prospects, offering a forward-looking to the next-generation of UV filters.

show abstract

“…Diagnostic tools have shown that currently one in three cancer cases is skin cancer of some type . UVA and UVB radiation has been proven to produce DNA damage directly and/or indirectly through DNA adducts or the generation of ROS, which promote tumor formation through various pathways .…”

Section: Introductionmentioning

confidence: 99%

“…[14] Diagnostic tools have shown that currently one in three cancer cases is skin cancer of some type. [15] UVAand UVB radiation has been proven to produce DNA damage directlya nd/or indirectly throughD NA adducts or the generation of ROS, which promote tumor formation through various pathways. [16] However,t he phototoxic effect of UVAr adiation is much lower than that of UVB, because UVAi se fficient at generating ROS that can damage DNA by indirect photosensitizing reactions, and such DNA, which causes molecular rearrangements forming the specific photoproducts, directly absorbsU VB.…”

Section: Introductionmentioning

confidence: 99%

A Multitarget Approach toward the Development of 8‐Substituted Purines for Photoprotection and Prevention of UV‐Related Damage

et al. 2017

View full text Add to dashboard Cite

Ultraviolet (UV) light is the most abundant and significant modifiable risk factor for skin cancer and many other skin diseases such as early photo-aging. Across the solar radiation spectrum, UV light is the main cause behind skin problems. In the search for novel photoprotective compounds, a new series of 8-substituted purines were synthesized from commercially available 6-hydroxy-4,5-diaminopyrimidine hemisulfate or 4,5-diaminopyrimidine. All title compounds were investigated for their UV filtering, antioxidant, antifungal, and antiproliferative activities. For the photoprotection assays we used a diffuse transmittance technique to determine the sun protection factor (SPF) in vitro, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric ion reducing antioxidant power (FRAP) tests for evaluating the antioxidant activity of the more potent compounds. Among them, 8-(2,5-dihydroxyphenyl)-7H-purin-6-ol (compound 26) proved to be a good radical scavenger and is also endowed with broad-spectrum UVA filtering capabilities, suitable for further development as a protective molecule.

show abstract

Quinolines derivatives as novel sunscreening agents

Cited by 11 publications

References 19 publications

Assessment of the Photoprotective Activity of Lippia Species from Brazil and Their use as Single UV Filters in Sunscreens

Assessment of the Photoprotective Activity of Lippia Species from Brazil and Their use as Single UV Filters in Sunscreens

UV Filters: Challenges and Prospects

A Multitarget Approach toward the Development of 8‐Substituted Purines for Photoprotection and Prevention of UV‐Related Damage

Contact Info

Product

Resources

About