Quinoline, quinazoline and acridone alkaloids

Determination of the absolute configuration of the enantiomers of dihydroquinolines, isolated by chiral chromatography, by non empirical analysis of circular dichroism spectra and X-ray analysis

“…The quinoline ring system is found in many natural products of interest due to its wide range of biological activities. 1,2 Hydroquinolines constitute a key structural motif present in many biologically-active compounds, many of which have industrial and medicinal applications.…”

Synthesis and in vitro antiproliferative activity of novel (4-chloro- and 4-acyloxy-2-butynyl)thioquinolines

“…Among a large group of synthetic and natural acetylenic compounds the quinolines possessing an alkynyl moieties are of particular interest as many of them display important activities, namely antimicrobiological, anticancer, antiprotozoal, and antiretroviral (Fuita et al ., 1998; Fakhfakh et al ., 2003; Abele et al ., 2002). Several acetylenic 2,5-disubstituted decahydroquinoline alkaloids of wide spectra biological activities have been isolated from the skins of frogs, toads and related amphibians (Spande et al ., 1999; Michael, 2000). It should be noted that less information is available concerning the synthesis and biological evaluation of alkynylthioquinolines (Abele et al ., 2002; Makisumi and Murabayashi, 1969; Boryczka, 1999).…”

Comparative (Photoenhanced) Toxicity of Homocyclic and Heterocyclic PACs

“…Apart from their natural origin, for example, as alkaloids (9,10), and the usual sources of PACs (see above), basic azaarene structures occur as moieties of pharmaceuticals (11,12) and pesticides (6), which causes azaarenes to enter the environment from additional sources totally unrelated to the sources of homocyclic PAHs. Furthermore, these azaarenes show a higher water solubility than their homocyclic analogues (13), which may imply a higher mobility in the aquatic environment.…”