Quinoline, quinazoline, and acridone alkaloids

Michael, J. P.

doi:10.1039/np9951200077

Cited by 46 publications

(19 citation statements)

References 18 publications

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“…Plants belonging to the Rutaceae family are a source of different classes of alkaloids, such as benzophenantridines, quinolines, furoquinolines, 2-alkylquinolines and acridines (Michael 2003, Waterman 1999. Representatives of these classes have been found in species that have folkloric antimalarial reputations and their antiplasmodial activities have been evaluated (summarized in the following section).…”

Section: Ellipticine Ellipticinium Aspidocarpinementioning

confidence: 99%

Plant-derived antimalarial agents: new leads and efficient phythomedicines. Part I. Alkaloids

Oliveira

Dolabela

Braga

et al. 2009

An. Acad. Bras. Ciênc.

127

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Malaria remains one of the most serious world health problem and the major cause of mortality and morbidity in the endemic regions. Brazil is among the 30 high-burden countries and most of the cases occur in the Legal Amazonian Region. New chemotherapeutical agents are needed for the treatment of malaria. Many plant species are used in traditional medicines of malarious countries and a relatively few number of these have been investigated for evaluation of their antimalarial effect. Still lower is the number of those that have had the active natural compounds isolated and the toxicity determined. This area is, then, of great research interest. A discovery project of antimalarial natural products from plants traditionally used to treat malaria must include in vitro and in vivo assays as well as bioguided isolation of active compounds. The final products would be antimalarial chemical entities, potential new drugs or templates for new drugs development, and/or standardized antimalarial extracts which are required for pre-clinical and clinical studies when the aim is the development of effective and safe phythomedicines. This review discusses these two approaches, presents briefly the screening methodologies for evaluation of antimalarial activity and focuses the activity of alkaloids belonging to different structural classes as well as its importance as new antimalarial drugs or leads and chemical markers for phytomedicines.

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Section: Ellipticine Ellipticinium Aspidocarpinementioning

confidence: 99%

Plant-derived antimalarial agents: new leads and efficient phythomedicines. Part I. Alkaloids

Oliveira

Dolabela

Braga

et al. 2009

An. Acad. Bras. Ciênc.

127

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“…The extract of A. laevis stems inhibited Pfnek at 50.7% and had an IC 50 of 5 µg/mL against FcB1 strain of P. falciparum, but the same extract was strongly cytotoxic against MCF7 cells at 3 µg/ml. The presence of quinoline and acridone alkaloids has been isolated from Acronychia species (Cui et al, 1999;Michael, 2001). Such compounds could explain the observed antimalarial and cytotoxic activities of A. laevis.…”

Section: Acronychia Laevis Jr Et Jg Forster (Rutaceae)mentioning

confidence: 95%

Antiplasmodial activity of New Caledonia and Vanuatu traditional medicines

Hnawia¹,

Hassani

Deharo

et al. 2011

Pharmaceutical Biology

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“…Quinolines are present in awide range of natural products with remarkable pharmacologicalp roperties [2][3]. In addition, ferrocenyl derivatives have found numeroususes in various fields of science from organic chemistry to biochemistry [4][5].…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of 6-bromo-2-ferrocenylquinoline, C19H14BrFeN

Feng

Song

et al. 2014

Zeitschrift Für Kristallographie - New Crystal Structures

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C 19 H 14 BrFeN, monoclinic, P2 1 /c (no. 14), a =9.8612(3) Å, b =13.8034(5) Å, c =11.3372(5) Å, b =90.072(3)°, Source of materialThetitle compound was prepared as described in literature [1]and recrystallized from dichloromethane/petroleum ether solution at room temperature to give the desired crystals suitable for singlecrystal X-raydiffraction. DiscussionQuinolines are present in awide range of natural products with remarkable pharmacologicalp roperties [2][3]. In addition, ferrocenyl derivatives have found numeroususes in various fields of science from organic chemistry to biochemistry [4][5]. Although quinolines are among the most extensively studied heterocyclic compounds [6][7], ferrocenylquinolines are not often found in the literature [1,[8][9][10][11]. Here we report the crystal structure of acompound, obtained via a-alkylation of acetylferrocene and(2-amino-5-bromophenyl)methanol. Aview of the molecular structure of the title compound is given in the figure. The two cyclopentadienyl rings are almost parallel with adihedral angle of 2.7°.The substitutedcyclopentadienyland quinolinyl ring are approximately coplanar, making adihedral angle of 16.1°. In the crystal there exist intermolecular C-Br×××Nhalogen bonds (Br×××N =3.197 Å) [12],which are attributed to constructaone-dimensional chain structure.

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Quinoline, quinazoline, and acridone alkaloids

Cited by 46 publications

References 18 publications

Plant-derived antimalarial agents: new leads and efficient phythomedicines. Part I. Alkaloids

Plant-derived antimalarial agents: new leads and efficient phythomedicines. Part I. Alkaloids

Antiplasmodial activity of New Caledonia and Vanuatu traditional medicines

Crystal structure of 6-bromo-2-ferrocenylquinoline, C19H14BrFeN

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