Quinoline Heterocycles: Synthesis and Bioactivity

Abstract

Among heterocyclic compounds, quinoline is a privileged scaffold that appears as an important construction motif for the development of new drugs. Quinoline nucleus is endowed with a variety of therapeutic activities, and new quinolone derivatives are known to be biologically active compounds possessing several pharmacological activities. Many new therapeutic agents have been developed by using quinoline nucleus. Hence, quinoline and its derivatives form an important class of heterocyclic compounds for the new drug development. Numerous synthetic routes have been developed for the synthesis of quinoline and its derivatives due to its wide range of biological and pharmacological activities. The article covers the synthesis as well as biological activities of quinoline derivatives such as antimalarial, anticancer, antibacterial, anthelmintic, antiviral, antifungal, antiinflammatory, analgesic, cardiovascular, central nervous system, hypoglycemic, and miscellaneous activities.

Bacterial Alkyl-4-quinolones: Discovery, Structural Diversity and Biological Properties

“…The central structural motif in the alkylquinolones is the 4-quinoline core, an aromatic nitrogencontaining heterocyclic compound that can participate in both electrophilic and nucleophilic substitution reactions (Figure 1). The quinoline scaffold commonly exists in various natural products, exhibiting a broad range of biological activities [15]. In the context of the alkylquinolones, the quinolone nucleus forms the core around which the diverse substituents are arranged.…”

Designing, Characterization, DFT, Biological Effectiveness, and Molecular Docking Analysis of Novel Fe(III), Co(II), and Cu(II) Complexes Based on 4-Hydroxy-2H-pyrano[3,2-c]quinoline-2,5(6H)-dione

“…Quinoline-dione is a heterocyclic ring system that consists of a quinoline moiety fused with a 1,4-diketone group. 1-Benzopyridine is an advantaged scaffold that shows as a significant construction subject for the enhancement of novel drug compounds, as it exhibits a wide range of biological effectiveness, such as bactericidal, antifungal, antimalarial, anthelmintic, anticonvulsant, cardiotonic, anti-inflammatory, and analgesic activities . Quinoline-dione can act as a bidentate ligand and form metal complexes with various transition and lanthanide metals .…”

Synthesis of Quinoline and Polyhydroquinoline Derivatives Using Phloroglucinol Cored Amino Functionalized Dendritic Polymer as Catalyst

“…Multi‐component reactions have a major role as a green synthetic tool to produce heterocyclic compounds [1,2] . Quinolines are biologically relevant heterocyclic compounds found in a variety of biological systems, including Cinchona alkaloids [3–5] . Quinoline derivatives exhibited a wide range of pharmacological activities, including antimalarial, [6] antiasthmatic, [7] antibacterial, [8] analgesic, [9] and anticancer [10] properties, among others.…”

“…[1,2] Quinolines are biologically relevant heterocyclic compounds found in a variety of biological systems, including Cinchona alkaloids. [3][4][5] Quinoline derivatives exhibited a wide range of pharmacological activities, including antimalarial, [6] antiasthmatic, [7] antibacterial, [8] analgesic, [9] and anticancer [10] properties, among others. Quinoline derivatives are also used in a variety of industrial antioxidants and colours.…”