Quinoline Derivatives with Different Functional Groups: Evaluation of Their Catecholase Activity

Abstract

In this work, we are interested in finding new catalysts for catecholase, whose principle is based on the oxidation reaction of catechol to o-quinone. In this context, we have studied a series of seven quinoline-based compounds. The present work indicates that the complexes formed between seven selected quinoline compounds and the copper salts viz. Cu(OAc)2, CuSO4, Cu(NO3)2, and CuCl2 elicit catalytic activities for the oxidation of catechol to o-quinone. The complexes formed with the Cu(OAc)2 salt show a much higher catalytic activity than the others, whereas the Cu(NO3)2 and CuCl2 salts formed complexes with low catalytic activity. This study also shows that the oxidation rate depends on two factors, namely the chemical structure of the ligands and the nature of the ions coordinated with the copper.

New Pyrazole‐Hydrazide Derivatives: Synthesis, Characterization, Highly Active Catecholase‐Like Catalyst, and Antibacterial Study

“…The obtained results unequivocally demonstrate the remarkable catalytic activities exhibited by the in situ formed combinations of L 1 ‐L 11 ligands with various copper salts. These combinations exhibited superior catalytic activities compared to numerous previous studies [57,58,59,60,61,62] . These findings underscore the distinctiveness of the L/M combinations and their potential significance in facilitating the oxidation of catechol.…”

“…These combinations exhibited superior catalytic activities compared to numerous previous studies. [57,58,59,60,61,62] These findings underscore the distinctiveness of the L/M combinations and their potential significance in facilitating the oxidation of catechol.…”

Synthesis and Evaluation of Promising Antibacterial, Antifungal, and Antioxidant Activities for New Imidazo[1,2‐A]Pyridine‐Derived Imines

“…Heterocyclic compounds, particularly those with nitrogen atoms in their structure, such as imidazopyridines, have garnered significant attention in various fields due to their versatile properties and diverse biological activities [1–4] . These compounds have demonstrated significant applications in pharmaceuticals, agrochemicals, food processing, and other industries [5–7] .…”

“…They exhibit diverse pharmacological activities, including anticancer, anti‐inflammatory, antiulcer, analgesic, antiprotozoal, antipyretic, antiviral, and other activities [11,12] . Moreover, imidazo[1,2‐a]pyridines have demonstrated efficacy in treating psychiatric disorders and autoimmune conditions, further expanding their medical applications [13,14] …”

Recyclable Ni-Containing Coordination Polymer as an Efficient Catalyst for the Synthesis of Oxindole and Quinoline Derivatives through the Borrowing Hydrogen Strategy

“…Oxindole derivatives are privileged heterocyclic cores, constituting an important skeleton in several compounds of pharmaceutical interest with significant biological activities (Scheme 1) [1][2][3][4][5][6][7][8]. The conventional approaches for the alkylation of oxindoles employed toxic alkyl halides, suffered from harsh reaction conditions, and exhibited poor regioselectivity alongside the generation of undesired side products [9,10].…”