Quinoline Derivatives. (7)

Abstract

Faculty, University of Meijo*2) 1) Condensation of (III) with ammonia, dimethylamine, piperidine, aniline, paniline, and 2, 4-dichloroaniline in ethanol gave the compounds (IV to IX) which were reduced to (X to XII), and acetylated to (XIII to XV). Application of phenol, p-nitro phenol, and p-cresol to (III) gave the compounds (XVI to XVII). Similar condensation of 4, 8-dichloroquinaldine with aniline, p-chloroaniline, p-nitroaniline, and anisidine in ethanol gave the compounds (XIX to XXII). 2) Similar condensation of 2-chlorolepidine or 2-chloro-5-nitrolepidine with pchloroaniline, p-nitroaniline, and p-anisidine gave (XXIII to XXV) and (XXVI to XXVII). The compound (XXIX), obtained by nitration of 2-hydroxylepidine followed by chlori nation, was identified with 2-chloro-6-nitrolepidine. Similar condensation of (XXIX) and 2-chloro-8-nitrolepidine with p-aminoaniline, p-chloroaniline, and p-anisidine gave the compounds (XXX to XXXV). These compounds were submitted to antifungal test with Candida.