Quinoline based polymeric drug for biological applications: synthesis, characterization, antimicrobial, and drug releasing studies

Abstract

Novel acrylate monomer of quinoline-based chalcone 1-(4-(7-chloroquinolin-4-ylamino)phenyl) acrylate (CPA) was synthesized using (4-(2-chloroquinolin-5-ylamino)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one (CPE) and acryloyl chloride. CPA is characterized by different techniques like IR, (1)H NMR and UV-visible spectrometry techniques. Poly(CPA), poly(CPA-co-AA) and poly(CPA-co-HEA) are prepared by solution polymerization technique using CPA, acrylic acid (AA) and hydroxyethylacrylate (HEA), respectively. The antimicrobial activities of the compounds are tested using four different micro-organisms. In vitro cumulative drug release studies are done using UV visible spectroscopic technique. The molecular weights of these polymers are found to be around 5000 g/mol. The synthesized polymers showed two stages of thermal decomposition temperature centred around 220 and 350 °C, respectively. The antimicrobial activity of the polymer sample is found to be very high and especially for gram-negative bacteria with a minimum value of 3.91 μg/mL. The in vitro drug-releasing rate is dependent on the comonomer, pH and temperature of the medium.

Cytoprotective effects of antioxidant supplementation on mesenchymal stem cell therapy

“…Quinoline is an important compound since its ring system is capable of being naturally or synthetically designed to produce a variety of quinoline derivatives with versatile biological, pharmacological, and technological applications (Kumar, Bawa, & Gupta, 2009;Singh, Nishal, Bhagwan, Saini, & Singh, 2018). In biopharma applications, quinoline derivatives are used as potent antimicrobial, antiviral, anticonvulsant, anti-inflammatory, anticancer, and antioxidant agents in many pathophysiological conditions (Kumar et al, 2009;Narwal et al, 2017;Uma, Suresh, Selvaraj, Karthik, & Arun, 2015;Wang, Zeng, Li, & Zeng, 2010).…”