Quinoline-based compounds as modulators of HIV transcription through NF-κB and Sp1 inhibition

Bedoya, Luis Miguel; Abad, María J. F.; Calonge, Esther; Saavedra, Luis Astudillo; Gutiérrez, Crisanto; Kouznetsov, Vladímir V.; Alcamí, José; Bermejo, Paulina

doi:10.1016/j.antiviral.2010.06.006

Cited by 58 publications

(29 citation statements)

References 39 publications

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“…Quinoline derivatives fascinate much interest due to their anti-amoebic, antiviral [1,2], anti-parasitic [3], antimicrobial [4] and anti-tubercular activities [5]. They possess antiproliferative [6], anti-neoplastic [7], and cytotoxic properties [8].…”

Section: Introductionmentioning

confidence: 99%

Molecular structure, FT-IR, FT-Raman, NBO, HOMO and LUMO, MEP, NLO and molecular docking study of 2-[(E)-2-(2-bromophenyl)ethenyl]quinoline-6-carboxylic acid

Ulahannan¹,

Panicker²,

Varghese

et al. 2015

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Section: Introductionmentioning

confidence: 99%

Molecular structure, FT-IR, FT-Raman, NBO, HOMO and LUMO, MEP, NLO and molecular docking study of 2-[(E)-2-(2-bromophenyl)ethenyl]quinoline-6-carboxylic acid

Ulahannan¹,

Panicker²,

Varghese

et al. 2015

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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“…Also, fused quinoline derivatives produce wide pharmacological activities such as antibacterial [8,9], antifungal [10], antimalarial [11], antiplasmodium [12] and anticancer [13,14] effects. Moreover, they have been reported to act as vesicular glutamate transporters [15] and HIVIntegrase inhibitors [16].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory activity of benzo[h]quinoline and benzo[h]chromene in human glioblastoma cells

Haiba¹,

Al‐Abdullah²,

Ghabbour³

et al. 2016

Trop. J. Pharm Res

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“…Oscillator strength values of compounds (1)(2)(3)(4)(5) in different solvents are reported in Tables 6,7,8,9 and 10. In addition, the transition dipole moment (μ) for compounds (1)(2)(3)(4)(5) from ground to excited state in Debye was estimated in different solvents (Table 11) using the following relation [34]:…”

Section: Determination Of Oscillator Strength and Transition Dipole Mmentioning

confidence: 99%

“…Its traces of interest date back to the beginning of the 20th century but the first reports on their medical applications began to appear in the Fifties as antibiotic drugs against tuberculosis and leprosy [3]. Quinoline derivatives are of considerable interest because of their chemistry and potentially beneficial biological activity, such as antibacterial, antifungal, antiviral, antiamoebic, antimalarial and antitumor activity [4][5][6][7]. Quinoline derivatives use as intermediate for the formation of various fused bi-cyclic heterocyclic compounds such as pyrazolo quinoline, thiazolo quinoline, oxazolquinoline [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

One Pot Synthesis, Photophysical and X-ray Studies of Novel Highly Fluorescent Isoquinoline Derivatives with Higher Antibacterial Efficacy Based on the In-vitro and Density Functional Theory

et al. 2015

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Series of cyano substituted isoquinoline dyes were synthesized by one-pot multicomponent reactions (MCRs) of aldehydes, malononitrile, 6-methoxy-1,2,3,4-tetrahydro-naphthalin-1-one and ammonium acetate. Results obtained from spectroscopic (FT-IR, (1)H-NMR, (13)C-NMR, EI-MS) and elemental analysis of synthesized compounds was in agreement with their chemical structures. Structure of the compound was further conformed by X-ray crystallographic. UV-vis and fluorescence spectroscopy measurements provided that all compounds are good absorbent and fluorescent. Fluorescence polarity study demonstrated that these compounds were sensitive to the polarity of the microenvironment provided by different solvents. In addition, spectroscopic and physicochemical parameters, including electronic absorption, extenction coefficient, Stokes shift, oscillator strength transition dipole moment and fluorescence quantum yield were investigated in order to explore the analytical potential of synthesized compounds. The anti-bacterial activity of these compounds were first studied in vitro by the disk diffusion assay against two Gram-positive and two Gram-negative bacteria. The minimum inhibitory concentration was then determined with the reference of standard drug chloramphenicol. The results displayed that compound 3 was better inhibitors of both types of the bacteria (Gram-positive and Gram-negative) than chloramphenicol. Furthermore, quantum chemistry calculations using DFT/6-31-G* level of theory confirm the results. Dipole moment and frontier molecular orbitals were also investigated.

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Quinoline-based compounds as modulators of HIV transcription through NF-κB and Sp1 inhibition

Cited by 58 publications

References 39 publications

Molecular structure, FT-IR, FT-Raman, NBO, HOMO and LUMO, MEP, NLO and molecular docking study of 2-[(E)-2-(2-bromophenyl)ethenyl]quinoline-6-carboxylic acid

Molecular structure, FT-IR, FT-Raman, NBO, HOMO and LUMO, MEP, NLO and molecular docking study of 2-[(E)-2-(2-bromophenyl)ethenyl]quinoline-6-carboxylic acid

Inhibitory activity of benzo[h]quinoline and benzo[h]chromene in human glioblastoma cells

One Pot Synthesis, Photophysical and X-ray Studies of Novel Highly Fluorescent Isoquinoline Derivatives with Higher Antibacterial Efficacy Based on the In-vitro and Density Functional Theory

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