Quinoline anhydride derivatives cross-linked chitosan hydrogels for potential use in biomedical and metal ions adsorption

Kandile, Nadia G.; Mohamed, Mohamed Bakr; Zaky, Howida T.; Nasr, Abir S.; Ali, Yassmin G.

doi:10.1007/s00289-021-03633-w

Cited by 11 publications

(9 citation statements)

References 47 publications

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“…This study is extension of our previous work for the preparation of new modified polymers for different applications [33][34][35][36][37][38], polyvinyl alcohol was taken as the basic matrix and modified with two heterocyclic compounds [N,Nʹ-bi-α-azido succinimide (A) and N-phthalimido-α-azido succinimide (P)] via their reaction in the absence or presence of glutaraldehyde as a cross-linker to enhance the physicochemical properties of PVA. The prepared membranes were characterized using FTIR spectrum, X-ray, thermal analysis (TGA) and scanning electron microscopy (SEM).…”

Section: Introductionmentioning

confidence: 97%

Poly(vinyl alcohol) membranes-inspired heterocyclic compounds for different applications: synthesis and characterization

Kandile

Nasr

2022

Polym. Bull.

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Chemical modification of poly(vinyl alcohol) (PVA) with different monomers is a convention method for the development of its properties. In this study, the new multifunctional membranes (PVA-A)1–3, (PVA-P)1–3, (PVA-AG) and (PVA-PG) were designed and synthesized by the reaction of PVA with heterocyclic compounds [N,Nʹ-bi-α-azido succinimide (A), N-phthalimido-α-azido succinimide (P)] and using glutaraldehyde (G) as cross-linker, respectively. The new membranes were characterized by FT-IR, TGA, SEM and X-ray diffraction. The swelling behavior of the membranes showed that membranes (PVA-P)1–3 exhibited the highest swelling capacity in different solvents. Their antibacterial against (Gram-negative), (Gram-positive) bacteria, and in vitro drug loading and release activities were evaluated. Additionally, metal ions adsorption capacity for copper, cobalt and mercury ions was studied. (PVA-AG) membrane performed the highest inhibitory effect to E. coli, Proteus, S. aureus and B. subtilis bacteria reached 22.9, 25.46, 24.9 and 30.56, respectively. Furthermore, in vitro controlled loading and release of lidocaine, (PVA-A)1 membrane revealed remarkable ability reached 57.37% and 94.59%, respectively. Hydrogel (PVA-AG) showed the highest metal ions (copper, cobalt and mercury) uptake efficiency (64.5, 69.5 and 73), respectively. Based on results, the prepared membranes can be suggested as promising agents for antibacterial, drug delivery systems and metal ions removal from aqueous medium.

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Section: Introductionmentioning

confidence: 97%

Poly(vinyl alcohol) membranes-inspired heterocyclic compounds for different applications: synthesis and characterization

Kandile

Nasr

2022

Polym. Bull.

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“…Chitosan is a cationic polymer that leads to react with the negatively charged molecules. Moreover, the existence of hydroxyl and amine groups in chitosan structure promotes its chemical reactions with heterocyclic compounds [7][8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Unique Sustain Anticancer Modified Chitosan Nanoparticle: Fabrication and Characterization

Ahmed,

Mohamed,

Ahmed

et al. 2024

Preprint

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Chitosan (CS) is a biopolymer offers a wide range in biomedical applications due to its biocompatibility, biodegradability, low toxicity and antimicrobial activity. Syringaldehyde (1) is naturally organic compound characterized by its uses in multiple fields such as pharmaceuticals, food, cosmetics, textiles and biological applications. Herein, development of chitosan physicochemical and anticancer properties via Schiff base formation from the reaction of chitosan with sustainable eco-friendly syringaldehyde yielded (CS-1) derivative. Moreover, in presence of polyethylene glycol diglycidyl ether (PEGDGE) or sodium tripolyphosphate (TPP) as crosslinkers gave chitosan derivatives (CS-2) and (CS-3NPs) respectively. The chemical structures of new chitosan derivatives are confirmed using different tools. (CS-3NPs) nanoparticle showed improvement in crystallinity, and (CS-2) derivative revealed the highest thermal stability compared to virgin chitosan. The cytotoxicity activity of chitosan and its derivatives is evaluated against HeLa (human cervical carcinoma) and HEp-2 (Human Larynx carcinoma) cell lines. The highest cytotoxicity activity is exhibited by (CS-3NPs) compared to virgin chitosan against HeLa cell growth inhibition and apoptosis of 90.38±1.46% and 30.3% respectively and IC50 of 108.01±3.94 µg/ml. From the above results, it can be concluded that chitosan nanoparticle (CS-3NPs) might be good therapeutic value as a potential antitumor agent against HeLa cancer cell line.

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“…Although Cs has received considerable attention for biological applications, its applicability is still limited owing to the existence of strong inter- and intra-molecular hydrogen bonds within its network and poor solubility in solvents used in the biomedical field, such as water. Recently, numerous studies have focused on improving the water solubility of Cs via chemical modifications [ 22 , 23 , 24 ]. Nevertheless, chemical modification processes are expensive, time consuming, environmentally unfriendly, and complicated, and present difficulties due to the formation of byproducts [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Regeneration Approach to Enhance the Antimicrobial and Antioxidant Activities of Chitosan for Biomedical Applications

Panda¹,

Sadeghi²,

Park³

et al. 2022

Polymers

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Owing to its biodegradability, non-toxicity, and biocompatibility, chitosan (Cs) is a ubiquitous biopolymer. However, applications of Cs are limited owing to the existence of strong inter- and intra-molecular hydrogen bonds within its network. To address this issue, we regenerated medium-molecular-weight Cs to enhance the physico-chemical and functional properties using a cationic approach. Accordingly, alkaline modification was employed to introduce an additional positive charge to the amine functional groups of Cs and moderately disintegrate the inter- and intra-hydrogen bonds. The chemical structure of Cs and regenerated chitosan (RCs) was confirmed through Fourier transform infrared and 1H-NMR spectroscopy. RCs showed higher zeta potential value compared to Cs. Additionally, using X-ray diffraction, RCs exhibited low crystallinity, which can be attributed to the repulsive force caused by the positive surface charge and the destruction of hydrogen bonds. The RCs exhibited stronger antioxidant activity than Cs. Furthermore, the minimum inhibition concentrations (MICs) of RCs against Escherichia coli and Staphylococcus aureus were reduced by almost four times compared with those of Cs. The superior functional properties of RCs can be attributed to the formation of a polycationic structure after alkaline modification. Thus, RCs can be introduced as potent agents for various biomedical purposes.

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Quinoline anhydride derivatives cross-linked chitosan hydrogels for potential use in biomedical and metal ions adsorption

Cited by 11 publications

References 47 publications

Poly(vinyl alcohol) membranes-inspired heterocyclic compounds for different applications: synthesis and characterization

Poly(vinyl alcohol) membranes-inspired heterocyclic compounds for different applications: synthesis and characterization

Unique Sustain Anticancer Modified Chitosan Nanoparticle: Fabrication and Characterization

Regeneration Approach to Enhance the Antimicrobial and Antioxidant Activities of Chitosan for Biomedical Applications

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