Quinoline alkaloids from Psychotria glomerulata

Solı́s, Pablo; Ravelo, Ángel G.; Palenzuela, J. Antonio; Gupta, Mahabir P.; González, Antonio G.; Phillipson, J. David

doi:10.1016/s0031-9422(96)00583-3

Cited by 33 publications

(21 citation statements)

References 11 publications

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“…[19], and from P. forsteriana [20] and P. glomerulata [21]. Consequently, the plant-derived d-calycanthine reported in this work is the (þ)-enantiomer of the known frog alkaloid calycanthine.…”

mentioning

confidence: 60%

Antifungal Activity of Alkaloids from the Seeds of Chimonanthus praecox

Zhang

Gao

et al. 2009

Chemistry & Biodiversity

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Two alkaloids, D-calycanthine (1) and L-folicanthine (2), were isolated from the active MeOH extract of the seeds of Chimonanthus praecox LINK. The structures of the two compounds were established by (1)H- and (13)C-NMR, and MS (FAB, ESI) analyses. In the in vitro tests, compounds 1 and 2 showed significant inhibitory activities against five plant pathogenic fungi Exserohilum turcicum, Bipolaris maydis, Alternaria solani, Sclerotinia sderotiorum, and Fusarium oxysportium, among which B. maydis was found to be the most susceptible to 1 with an EC(50) value of 29.3 microg/ml, followed by S. sderotiorum to 2 with an EC(50) value of 61.2 microg/ml. To our knowledge, this is the first report of isolation and LC/MS/MS identification as well as of antifungal properties of these alkaloids from the seeds of this plant.

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confidence: 60%

Antifungal Activity of Alkaloids from the Seeds of Chimonanthus praecox

Zhang

Gao

et al. 2009

Chemistry & Biodiversity

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“…66 From the aerial parts of P. glomerulata were isolated three quinoline alkaloids such as glomerulatine A (46), B (47) and C (48). 53 From extracts of the leaves and the roots of P. correae were obtained isodolichantoside (49) and the alkaloids correantoside (50), 10-hydroxycorreantoside (51), correantine A (52), B (53), and C (54), and 20-epi-correantine B (55). 48 P. forsteriana afforded three alkaloids (−)-calycanthine (56), iso-calycanthine (57), and meso-chimonanthine (38), a dimeric indole isomeric.…”

Section: Alkaloidsmentioning

confidence: 99%

The GenusPsychotria: Phytochemistry, Chemotaxonomy, Ethnopharmacology and Biological Properties

Calixto¹,

Pinto²,

Ramalho³

et al. 2016

Journal of the Brazilian Chemical Society

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Psychotria genus (Rubiaceae) is featured into the angiosperm, being the most speciose genus comprising approximately 1600 species. The available references demonstrate that Psychotria has several uses on traditional medicine including spiritual and cultural purposes, and presents great potential on pharmacological properties, especially the one related to neurodegenerative diseases. Despite its wide biological properties, this genus has shown complex phylogenetic analysis due to lack of chemotaxonomic information. In recent years, the interest in these plants has increased considerably and many active compounds have been isolated. Phytochemical investigations described in the literature confirmed the indole alkaloids as the major compounds and besides that, another particular chemical constituent are cyclic peptides, known as cyclotides. This present review will cover the relevant literature from 1962 until 2015, and outlines the current data on taxonomy, chemotaxonomy, traditional uses, pharmacological properties, chemical composition and ecological approach from Psychotria genus.

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“…Smith) Steyermark, previously known as Cephaelis glomerulata J.D. Sm [37]. The dimeric structures were determined by spectroscopic means.…”

Section: Glomerulatinesmentioning

confidence: 99%

“…from the Red Sea[73]. From other marine sponges, ptilomycalins (A, 32)[74,75] and crambescidin 800 (33)[75] have also been isolated as a series of guanidine alkaloids(Figure 10.9).Batzelladine A (34) and the derivatives B-E(35)(36)(37)(38) are the first natural products of small molecule weight that have been shown to inhibit the gp120-CD4 interaction[76]. On the other hand, batzelladines F-I (39-42) induced a dissociation of a p56ck-CD4 binding complex[77].…”

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confidence: 99%

Amidines and Guanidines in Natural Products and Medicines

Kumamoto¹

2009

Superbases for Organic Synthesis

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Quinoline alkaloids from Psychotria glomerulata

Cited by 33 publications

References 11 publications

Antifungal Activity of Alkaloids from the Seeds of Chimonanthus praecox

Antifungal Activity of Alkaloids from the Seeds of Chimonanthus praecox

The GenusPsychotria: Phytochemistry, Chemotaxonomy, Ethnopharmacology and Biological Properties

Amidines and Guanidines in Natural Products and Medicines

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