Quinine for muscle cramps

El-Tawil, Sherif; Musa, Tarique A; Valli, Haseeb; Lunn, Michael P.; Brassington, Ruth; El-Tawil, Tariq; Weber, Markus

doi:10.1002/14651858.cd005044.pub3

Cited by 63 publications

(33 citation statements)

References 61 publications

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“…The precise mechanism by which quinine may help muscle cramps is unknown, but one hypothesis is that it decreases the excitability of the motor end plate, reducing muscle contractility. 15 A Cochrane review 16 analyzed 23 trials in which quinine was compared to a placebo (20 trials), vitamin E (four trials), a quinine-vitamin E combination (three trials), a quinine-theophylline combination (one trial), and Xylocaine injections (one trial). The reviewers concluded that there was low-quality evidence that quinine significantly reduces the number of cramp days and moderate-quality evidence that quinine reduces the intensity of cramps.…”

Section: Discussionmentioning

confidence: 99%

Quinine and the ABCs of Long QT: A Patient’s Misfortune with Arthritis, (Alcoholic) Beverages, and Cramps

et al. 2016

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A 91-year-old woman presented to the emergency department by ambulance after her family found her minimally responsive. Telemetry monitoring demonstrated episodes of non-sustained polymorphic ventricular tachycardia (PMVT) associated with significantly prolonged repolarization. Her medical history revealed that she was taking quinine or a derivative in three different forms: hydroxychloroquine, quinine sulfate (for leg cramps), and her gin mixed with tonic water (containing quinine). The present case is illustrative of classic etiologies and findings of acquired long QT syndrome, and serves as an important reminder for providers to take a complete medication history, including use of duplicative and alternative medicines and type of alcohol consumption.KEY WORDS: cardiac arrhythmia; prolonged QT; quinine; gin and tonic.

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Section: Discussionmentioning

confidence: 99%

Quinine and the ABCs of Long QT: A Patient’s Misfortune with Arthritis, (Alcoholic) Beverages, and Cramps

et al. 2016

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“…Results remain mixed on the use of stretching [1] and ingestion of pickle juice [4] as a prevention therapy. One well-studied pharmacological treatment that is highly effective in reducing muscle cramps is quinine sulfate [5]; however, the side effects associated with quinine sulfate ingestion suggest caution of its use as a long-term treatment. Calcium channel blockers, Verapamil [6] and Diltiazem [7], have proven effective in treating nocturnal muscle cramps, but with many pharmaceuticals there are risks of adverse side effects.…”

Section: Discussionmentioning

confidence: 99%

Effect of Bacrobial® Skin Cleanser on the Prevention of Muscle Cramps

Goodman¹,

Zwetsloot²,

Needle³

2015

JSS

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On the first trial, Bacrobial ® was liberally applied to the skin over the triceps surae musculature of one leg, while placebo was applied to the other leg. At 1, 5, 10, and 20 min after application, participants were instructed to induce a cramp in the triceps surae via maximal voluntary contraction. For the second trial, treatments were applied to the opposite leg as in trial one and the cramping procedure was repeated. OUTCOME MEASURES: Incidence of cramping was the main outcome measure and event-odds tables, risk reduction and NNT (numbers needed to treat) or NNH (numbers needed to harm) were calculated at the time intervals of 1, 5, 10 and 20 minutes. RESULTS: No significant differences between treatments were found in cramping incidences at all time intervals. Bacrobial ® decreased the risk of cramping by 12.5% at one minute (NNT = 8), while causing a 5.3%increased risk at five minutes (NNH = 5.3). CONCLUSIONS: Our findings indicate Bacrobial ® skin cleanser is not an overall effective treatment for muscle cramp prevention. However, the observed results at one minute may be useful to clinicians who treat cramp-prone patients.

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“…The authors concluded that there was low -quality evidence that quinine significantly reduces cramp number or cramp days but moderate quality evidence for a reduction in cramp intensity. 78 Quinine has been associated with serious adverse effects; however, the authors demonstrated moderate quality evidence that its use for up to 60 days is not associated with more serious adverse events compared with placebo, although minor side effects, most commonly gastrointestinal symptoms, occurred more often. 78 Quinine has previously been associated with serious and potentially fatal immune -mediated reactions, such as thrombocytopenia, with an incidence rate of 1.7/1000 person -years.…”

Section: Referencesmentioning

confidence: 99%