Quinine and Quinine Analogues

Hofheinz, W.; Merkli, B.

doi:10.1007/978-3-642-69254-3_2

Cited by 23 publications

(8 citation statements)

References 48 publications

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“…They are inhibitors of the erythrocytic form of malarial parasites [1], but their mechanism of action continues to be debated. Cinchonine (C 19 H 22 N 2 O ¼ cin; Scheme 1) is one of the four main alkaloids-constituents of Cinchona tree bark.…”

Section: Introductionmentioning

confidence: 99%

Aggregation phenomena of cinchonine in aqueous solutions observed and analysed by 2D FT-Raman spectroscopy

Wesełucha–Birczyńska

2004

Vibrational Spectroscopy

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Section: Introductionmentioning

confidence: 99%

Aggregation phenomena of cinchonine in aqueous solutions observed and analysed by 2D FT-Raman spectroscopy

Wesełucha–Birczyńska

2004

Vibrational Spectroscopy

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“…Subsequently synthetic antimalarials were produced. Quinacrine (atabrine, mepacrine, chinacrin), an acridine compound, was the first antimalarial to be synthesized (4). Quinacrine replaced quinine as an antimalarial compound in World War II when over 3 million American servicemen each took quinacrine for 4 years.…”

Section: Introductionmentioning

confidence: 99%

New concepts in antimalarial use and mode of action in dermatology

2007

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Although chloroquine, hydroxychloroquine and quinacrine were originally developed for the treatment of malaria, these medications have been used to treat skin disease for over 50 years. Recent clinical data have confirmed the usefulness of these medications for the treatment of lupus erythematosus. Current research has further enhanced our understanding of the pharmacologic mechanisms of action of these drugs involving inhibition of endosomal toll-like receptor (TLR) signaling limiting B cell and dendritic cell activation. With this understanding, the use of these medications in dermatology is broadening. This article highlights the different antimalarials used within dermatology through their pharmacologic properties and mechanism of action, as well as indicating their clinical uses. In addition, contraindications, adverse effects, and possible drug interactions of antimalarials are reviewed.

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“…The smallest reported lethal dose in an adult is 1.5g 5 and death has been reported in a child after a dose of Ig 6 . The average lethal dose is 8g 5 , though there is wide variation in toxic doses.…”

Section: Discussionmentioning

confidence: 99%