Quinine Actinometry as a Method for Calibrating Ultraviolet Radiation Intensity in Light-Stability Testing of Pharmaceuticals

Yoshioka, Shin; Ishihara, Yumi; Terazono, Tomio; Tsunakawa, N.; Murai, Miki; Yasuda, Tsutomu; Kitamura,; Kunihiro, Yasuyuki; Sakai, Ken; Hirose, Yoichi; Tonooka, Kazuhiko; Takayama, Kotaro; Imai, Fumikazu; Godo, Masayuki; Matsuo, Michimasa; Nakamura, Kōichi; Aso, Y.; Kojima, Saburo; Takeda, Yoshihiko; Terao, Terumi

doi:10.3109/03639049409050221

Cited by 17 publications

(7 citation statements)

References 5 publications

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“…Two main considerations may be drawn when applying the statistical analysis described in the present study. First, the agreement of the confidence interval of the 2% and 5% (m/v) curves obtained by us with the 5% (w/v) concentration curve obtained by Yoshioka et al [9] is not statistically comparable with 95% of confidence. This implies that Yoshiokaǐs results should not be generalized to any UV lamp.…”

Section: Quinine Actinometry Methodsmentioning

confidence: 95%

“…2 and the results of the angular and linear coefficients of both curves are described in Table 1, which also presents Yoshiokaǐs data [9]. Two main considerations may be drawn when applying the statistical analysis described in the present study.…”

Section: Quinine Actinometry Methodsmentioning

confidence: 99%

“…A confidence interval of 95%, with alpha = 5% and n − 2 degrees of freedom, has been constructed for the absorption curves of the 2% and 5% (m/v) quinine solutions in order to compare with the results obtained by Yoshiokaǐs group [9]. Two different situations were evaluated: (1) the agreement of the confidence interval of the 2% and 5% (m/v) curves obtained by us with the 5% (m/v) concentration curve obtained by Yoshioka and (2) the agreement confidence interval of the 2% and 5% (m/v) curves in relationship to each other measured in the same photostability chamber.…”

Section: Methodsmentioning

confidence: 99%

“…Prof. Arthur de Sá, s/n, Cidade Universitária, 50740- pharmaceuticals [1][2][3]6]. The known paper of Yoshioka et al [9] proposed quinine actinometry as a universal standardized method for calibrating UV intensity in light sources [9]. This paper presented a joint study of seven different laboratories and showed that there is a linear correlation between the quinine absorbance and the integrated UV radiation.…”

Section: Introductionmentioning

confidence: 94%

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Considerations on the quinine actinometry calibration method used in photostability testing of pharmaceuticals

Filho¹,

Gomes

Guedes³

et al. 2011

Journal of Pharmaceutical and Biomedical Analysis

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This paper addresses two critical issues concerning the guidelines adopted by the ICH on the photostability testing: the quinine actinometry method and the light/radiation exposure map distribution of the photostability chamber. Using a qualified non-commercial photostability chamber tests were performed using quinine and physical actinometry and compared the results to those which are used as the basis of the ICH guidelines. The statistical analysis on the results showed that: (i) the calibration curve of the quinine solution depends on its concentration and on its location in the chamber; (ii) the quinine actinometry method currently recommended by the ICH guidelines should not be generalized to any photostability chamber.

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Section: Quinine Actinometry Methodsmentioning

confidence: 95%

Section: Quinine Actinometry Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

See 2 more Smart Citations

Considerations on the quinine actinometry calibration method used in photostability testing of pharmaceuticals

Filho¹,

Gomes

Guedes³

et al. 2011

Journal of Pharmaceutical and Biomedical Analysis

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“…Following this study FTIR spectra were determined and compared with the samples not exposed to light (i.e. kept in a dark place at 4°C) [29].…”

Section: Photo-stabilitymentioning

confidence: 99%

Stability analysis of primary emulsion using a new emulsifying agent gum odina

Samanta¹,

Ojha²,

Mukherjee³

2010

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Gum odina and various parts of the plant Odina wodier are traditionally used in Indian folk medicine. Here an effort was made to investigate the efficacy of gum odina as new pharmaceutical excipients, in particular, as an emulsifying agent. Primary emulsion was prepared using wet gum method taking oil: water: gum (4:2:1) with gum acacia powder as an emulsifying agent. This was used as a standard control formulation. In case of experimental emulsions the primary emulsion was prepared by same wet gum technique taking oil: water: gum (4:2:0.5) (gum content was just a half of gum acacia) by using gum odina powder as an emulsifier. The gum odina as emulsifying agent provided a stable emulsion at a very low concentration as compared to the amount required for other conventional natural emulsifying agents. Stability studies of the emulsion were made as per the ICH guideline to study thermal stability, photosensitivity, pH related stability and stability in presence of oxygen. The emulsion type was identified by staining techniques (dye test by using Sudan III) as o/w type preparation without creaming or cracking even after long storage for 24 months at 25°C. It was found that the emulsion containing gum odina produced more stable emulsion at a much lower amount as compared to the emulsion stabilized by gum acacia.

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Quinine

Nawara¹

2024

Encyclopedia of Toxicology

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Quinine Actinometry as a Method for Calibrating Ultraviolet Radiation Intensity in Light-Stability Testing of Pharmaceuticals

Cited by 17 publications

References 5 publications

Considerations on the quinine actinometry calibration method used in photostability testing of pharmaceuticals

Considerations on the quinine actinometry calibration method used in photostability testing of pharmaceuticals

Stability analysis of primary emulsion using a new emulsifying agent gum odina

Quinine

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