Quinazolines and 1,4-Benzodiazepines. III.¹ Substituted 2-Amino-5-phenyl-3H-1,4-benzodiazepine 4-Oxides

Synthesis and Characterization of 1,2-disubstituted -3-(pyrimidine-2-yl)-2,3- dihydro-1H-1,3-diazepine-4,7-dione

“…Finally, preparation compounds (7-18) from reacted of compounds (4-6) with various amines compounds are identified by their m.p. (see table 1), and the important absorptions of FTIR of compounds (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) as showing in Table (4), and 1 HNMR. It is important to note that the two absorption bands at (1800-1920) cm 1 and (1640-1780) cm -1 in the FTIR spectrum of pure maleic anhydride has disappear, when the anhydride became part of the 7-membered ring of the compounds (4-6), In addition, the nitrogen atom carry hydrogen, closure through elimination of water molecular to the cyclic structure and FTIR spectrum showed carbonyl group (CO) stretching band at 14 (3), September, 2011, pp.24-34 Science no.…”

“…Irradiation of 4-phenyl-2-oxa-3-azabicyclo [3.2.0] hepta-3, 6-diene in nhexane gave 2-phenyl-1, 3-oxazpeine in 80% yield [3][4][5][6][7][8] . Many of the benzodiazepines and their oxides show interesting sedatives, muscle relaxant, and anticonvulsant properties in animals [9].…”

Preparation of 2‐aminobenzophenones and polysubstituted quinolines through SmI2 promoted reductive cleavage of 3‐aryl‐2,1‐benzisoxazoles

“…Of which classical preparation method requires appropriately substituted aniline substrates and high temperature reaction conditions [12], previously reported catalytic reduction of 2,1-benzisoxazoles to give 2-aminobenzophenones necessitates the use of expensive palladium as a catalyst [13]. In addition, aluminum tri-iodide has also been used to promote the cleavage of 2,1-benzisoxazoles to give 2-aminobenzophenones under reflux conditions [6a].…”

Classics in Chemical Neuroscience: Diazepam (Valium)

“…10 Given the interesting pharmacological properties of 2, 11 further exploration of the reactions of the benzodiazepine structure found that acidic hydrolysis of 2 produced N-oxide 8 which could be alkylated at the secondary amide nitrogen with methyl iodide, and the N-oxide reduced with either PCl 3 or Raney nickel to provide diazepam. 12 However, this synthesis was cumbersome and not permissive for the rapid development of analogues. 13 Another route was developed by Sternbach and colleagues using the same amino-benzophenone starting material 5 used to generate 7.…”