Quinacrine (Atabrine) in Treatment of Solar Dermatoses

Woodburne, Arthur R.

doi:10.1001/archderm.1954.01540190118012

Cited by 15 publications

(4 citation statements)

References 2 publications

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“…While chloroquine has shown efficacy in the treatment of PMLE, it has an unacceptable risk for ocular toxicity. The ocular toxicity is believed to come from chloroquine's affinity for melanin (44–47). Since there are other forms of treatment, including other antimalarial drugs, this drug is currently not recommended for use in patients with this disease.…”

Section: Other Therapiesmentioning

confidence: 99%

Polymorphic light eruption

et al. 2003

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Polymorphic light eruption (PMLE) is the most common photodermatosis. It is typically characterized by nonscarring, pruritic, erythematous papules, plaques, or vesicles on sun-exposed skin that develop 30 minutes to several hours after sun exposure. The eruption may persist for a few hours to as long as 2 weeks. Females are affected two to three times more often than males. PMLE has been reported in all races, but tends to affect fair-skinned individuals with Fitzpatrick skin types I-IV most commonly. The pathogenesis of PMLE has been difficult to define, although it appears to be an immune-mediated delayed-type hypersensitivity reaction. Abnormalities of arachidonic acid metabolism and a possible correlation with lupus are other theories that are reviewed. Treatment options have been explored extensively. While "hardening" or desensitization of the skin through repeated irradiation seems to be the most effective, therapeutic options such as sun avoidance/sun protection, oral carotenoids, and antimalarials are also considered.

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Section: Other Therapiesmentioning

confidence: 99%

Polymorphic light eruption

et al. 2003

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“…Similarly solar urticaria may respond to antimalarials. Woodburn et al (22) and Sams et al (23) have shown that both QE and CQ result in increased sunlight tolerance with improvement in symptoms such as itching and burning.…”

Section: Clinical Studiesmentioning

confidence: 99%

“…Systemically administered 4‐aminoquinolines are bound heavily in the epidermis and absorb UV light in a concentration‐dependent manner (23). Quinacrine has been shown to impede photodynamic actions and can inhibit laser‐induced photosensitivity (22). However, there has been no demonstrable effect of these agents on the minimal erythema dose.…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

Antimalarials

VanBeek

Piette

2001

Dermatol Ther

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Over the last century, antimalarial medications have become the parenteral drugs of choice for treating the cutaneous manifestations of lupus erythematosus. The effects of immune modulation with the concomitant preservation of host immune response to exogenous antigens procures these agents as powerful tools in a wide range of conditions. With prudent dosage and monitoring, antimalarials can be used safely and effectively in the treatment and management of autoimmune connective tissue disease.

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“…The antimalarial drugs quinacrine (Atabrine), chloroquine (Aralen), and hydroxychloroquine (Plaquenil) are effective agents for the prevention and treatment of polymorphous light eruption [1][2][3][4][5][6] and also for the treatment of discoid lupus erythematosus. 5,7 A new antimalarial compound, amodiaquin (Camoquin), recently has been reported to be equally valuable in the treatment of discoid lupus erythematosus.8,9…”

mentioning

confidence: 99%

The Use of Amodiaquin (Camoquin) in the Treatment of Polymorphous Light Eruption

Cahn¹

1958

Arch Dermatol

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Quinacrine (Atabrine) in Treatment of Solar Dermatoses

Cited by 15 publications

References 2 publications

Polymorphic light eruption

Polymorphic light eruption

Antimalarials

The Use of Amodiaquin (Camoquin) in the Treatment of Polymorphous Light Eruption

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