Quiet Submillimeter MR Imaging of the Lung Is Feasible with a PETRA Sequence at 1.5 T

Dournes, Gaël; Grodzki, David; Macey, Julie; Girodet, Pierre‐Olivier; Fayon, Michaël; Chateil, Jean‐François; Montaudon, Michel; Berger, Patrick; Laurent, François

doi:10.1148/radiol.15141655

Cited by 124 publications

(62 citation statements)

References 25 publications

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“…Ultrashort echo time (UTE) imaging has be shown to be ideal for imaging lung parenchyma and evaluating lung microstructure at the alveolar level. 10,11 Most 3D UTE sequences combine short non-selective RF pulses with a 3D centre out radial trajectory. Scan time can be reduced by using a more efficient stack-of-spirals trajectory.…”

Section: Discussionmentioning

confidence: 99%

“…21 Similarly, UTE imaging has been shown to enable visualisation of other lung disease within the lung parenchyma. 10 Utilisation of UTE imaging in radiation therapy has mainly been for deriving substitute CT data for planning from the MRI data. 22 However, UTE imaging can be utilised to assess lung architecture during the course of treatment and post treatment.…”

Section: Discussionmentioning

confidence: 99%

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Feasibility of free breathing Lung MRI for Radiotherapy using non-Cartesian k-space acquisition schemes

Kumar

Rai

Stemmer

et al. 2017

BJR

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Objective:To test a free-breathing MRI protocol for anatomical and functional assessment during lung cancer radiotherapy by assessing two non-Cartesian acquisition schemes based on T 1 weighted 3D gradient recall echo sequence: (i) stack-of stars (StarVIBE) and (ii) spiral (SpiralVIBE) trajectories. Methods:MR images on five healthy volunteers were acquired on a wide bore 3T scanner (MAGNETOM Skyra, Siemens Healthcare, Erlangen, Germany). Anatomical image quality was assessed on: (1) free breathing (StarVIBE), (2) the standard clinical sequence (volumetric interpolated breath-hold examination, VIBE) acquired in a 20 second (s) compliant breath-hold and (3) 20 s non-compliant breath-hold. For functional assessment, StarVIBE and the current standard breath-hold time-resolved angiography with stochastic trajectories (TWIST) sequence were run as multiphase acquisitions to replicate dynamic contrast enhancement (DCE) in one healthy volunteer. The potential application of the SpiralVIBE sequence for lung parenchymal imaging was assessed on one healthy volunteer. Ten patients with lung cancer were subsequently imaged with the StarVIBE and SpiralVIBE sequences for anatomical and structural assessment. For functional assessment, free-breathing StarVIBE DCE protocol was compared with breath-hold TWIST sequences on four prior lung cancer patients with similar tumour locations. Image quality was evaluated independently and blinded to sequence information by an experienced thoracic radiologist. Results:For anatomical assessment, the compliant breath-hold VIBE sequence was better than free-breathing StarVIBE. However, in the presence of a non-compliant breath-hold, StarVIBE was superior. For functional assessment, StarVIBE outperformed the standard sequence and was shown to provide robust DCE data in the presence of motion. The ultrashort echo of the SpiralVIBE sequence enabled visualisation of lung parenchyma. Conclusion:The two non-Cartesian acquisition sequences, StarVIBE and SpiralVIBE, provide a free-breathing imaging protocol of the lung with sufficient image quality to permit anatomical, structural and functional assessment during radiotherapy. Advances in knowledge:Novel application of non-Cartesian MRI sequences for lung cancer imaging for radiotherapy. Illustration of SpiralVIBE UTE sequence as a promising sequence for lung structural imaging during lung radiotherapy. To test a free-breathing MRI protocol for anatomical and functional assessment during lung cancer radiotherapy by assessing two non-Cartesian acquisition schemes based on T 1 weighted 3D gradient recall echo sequence: (i) stack-of stars (StarVIBE) and (ii) spiral (SpiralVIBE) trajectories. Methods: MR images on five healthy volunteers were acquired on a wide bore 3T scanner (MAGNETOM Skyra, Siemens Healthcare, Erlangen, Germany). Anatomical image quality was assessed on: (1) free breathing (StarVIBE), (2) the standard clinical sequence (volumetric interpolated breath-hold examination, VIBE) acquired in a 20 second (s) compliant breath-hold and ...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Feasibility of free breathing Lung MRI for Radiotherapy using non-Cartesian k-space acquisition schemes

Kumar

Rai

Stemmer

et al. 2017

BJR

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“…While significant headway has been made in improving structural lung assessment via MRI, the spatial resolution remains poor relative to CT (Figures 5A,B) [PETRA achieved a voxel size of 0.86 mm 3 compared to 0.2 mm 3 from a state of the art CT scanner (19)] and image acquisition time remains high [8–12 min for PETRA (33), 7–10 min for respiratory triggered PROPELLER (31) compared to a fraction of a second via CT]. Lung MRI may, however, have far more to offer in terms of quantitative and functional data output.…”

Section: Evolution Of Imaging Techniques Relevant To Bpdmentioning

confidence: 99%

Imaging Bronchopulmonary Dysplasia—A Multimodality Update

2017

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Bronchopulmonary dysplasia is the most common form of infantile chronic lung disease and results in significant health-care expenditure. The roles of chest radiography and computed tomography (CT) are well documented but numerous recent advances in imaging technology have paved the way for newer imaging techniques including structural pulmonary assessment via lung magnetic resonance imaging (MRI), functional assessment via ventilation, and perfusion MRI and quantitative imaging techniques using both CT and MRI. New applications for ultrasound have also been suggested. With the increasing array of complex technologies available, it is becoming increasingly important to have a deeper knowledge of the technological advances of the past 5–10 years and particularly the limitations of some newer techniques currently undergoing intense research. This review article aims to cover the most salient advances relevant to BPD imaging, particularly advances within CT technology, postprocessing and quantitative CT; structural MRI assessment, ventilation and perfusion imaging using gas contrast agents and Fourier decomposition techniques and lung ultrasound.

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“…Preliminary data also suggest that lesion registration is improved through hybrid PET/MRI, an advantage that will potentially improve tissue segmentation, attenuation correction, and ultimately PET quantification [20]. Although CT is superior to MRI for detection of small lung nodules, emerging rapid high-resolution MRI sequences will likely mitigate this difference [21]. …”

Section: Advantages Of Hybrid Pet/mri Versus Pet/ctmentioning

confidence: 99%

Current Status of Hybrid PET/MRI in Oncologic Imaging

Rosenkrantz

Friedman

Chandarana

et al. 2016

American Journal of Roentgenology

101

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OBJECTIVE This review article explores recent advancements in PET/MRI for clinical oncologic imaging. CONCLUSION Radiologists should understand the technical considerations that have made PET/MRI feasible within clinical workflows, the role of PET tracers for imaging various molecular targets in oncology, and advantages of hybrid PET/MRI compared with PET/CT. To facilitate this understanding, we discuss clinical examples (including gliomas, breast cancer, bone metastases, prostate cancer, bladder cancer, gynecologic malignancy, and lymphoma) as well as future directions, challenges, and areas for continued technical optimization for PET/MRI.

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Quiet Submillimeter MR Imaging of the Lung Is Feasible with a PETRA Sequence at 1.5 T

Abstract: PETRA enables silent, free-breathing, isotropic, and submillimeter imaging of the bronchi and lung parenchyma with high CNR and SNR and may be an alternative to CT for patients with cystic fibrosis.

Cited by 124 publications

References 25 publications

Feasibility of free breathing Lung MRI for Radiotherapy using non-Cartesian k-space acquisition schemes

Feasibility of free breathing Lung MRI for Radiotherapy using non-Cartesian k-space acquisition schemes

Imaging Bronchopulmonary Dysplasia—A Multimodality Update

Current Status of Hybrid PET/MRI in Oncologic Imaging

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