Quiescence of adult oligodendrocyte precursor cells requires thyroid hormone and hypoxia to activate Runx1

Tokumoto, Yuki; Tamaki, Shinpei; Kabe, Yoshio; Takubo, Keiyo; Suematsu, Makoto

doi:10.1038/s41598-017-01023-9

Cited by 15 publications

(16 citation statements)

References 71 publications

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“…We identified TF regulatory modules that exhibit sequential progression along the oligodendrocyte lineage (Figures 4F and S5B ; Table S4 ). These previously uncharacterized temporal modules comprised oligodendrocyte lineage progression TFs (e.g., Kcnip3 , Olig2 , Sox2 , and Klf9 ; Maki et al, 2013 ; Marques et al, 2016 ; Tokumoto et al, 2017 ; Wu et al, 2012 ) and co-expression partners (e.g., Hes5 , Eno1 , Sox21 , Purb , Zfp275 , Foxj2 , Zeb2 , Tsc22d3 , and Hopx ; Figure 4F ). Among these, Sox2 and Sox21 interaction are regulators of pluripotency and human glioma progression ( Caglayan et al, 2013 ; Kuzmichev et al, 2012 ).…”

Section: Resultsmentioning

confidence: 99%

Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages

et al. 2019

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SUMMARY The ventricular-subventricular zone (V-SVZ) harbors adult neural stem cells. V-SVZ neural stem cells exhibit features of astrocytes, have a regional identity, and depending on their location in the lateral or septal wall of the lateral ventricle, generate different types of neuronal and glial progeny. We performed large-scale single-cell RNA sequencing to provide a molecular atlas of cells from the lateral and septal adult V-SVZ of male and female mice. This revealed regional and sex differences among adult V-SVZ cells. We uncovered lineage potency bias at the single-cell level among lateral and septal wall astrocytes toward neurogenesis and oligodendrogenesis, respectively. Finally, we identified transcription factor co-expression modules marking key temporal steps in neurogenic and oligodendrocyte lineage progression. Our data suggest functionally important spatial diversity in neurogenesis and oligodendrogenesis in the adult brain and reveal molecular correlates of adult NSC dormancy and lineage specialization.

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Section: Resultsmentioning

confidence: 99%

Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages

et al. 2019

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“… 98 In a separate study, RUNX1 overexpression in a glioblastoma cell line down-regulated genes involved in the hypoxic response including the known HIF-1α targets hexokinase 2 (HK 2), caveolin 1 (CAV1), adenosine A2B receptor, and protein phosphatase 1 regulatory subunit 3C gene (PPP1R3C). 99–101 RUNX1 itself may be up-regulated by HIF-1α, as chemical stabilizers of HIF-1α including dimethyloxalylglycine (DMOG) and cobalt chloride (CoCl 2 ) have been shown to increase RUNX1 expression 102–104 and a correlation between RUNX1 and HIF-1α transcripts was identified in hippocampal transcriptomic data from in-bred mouse strains. 78 Whether RUNX1 interacts with HIF-1α in the heart has not been elucidated.…”

Section: Interaction Of Runx1 With Signalling Pathways Involved Inmentioning

confidence: 99%

RUNX1: an emerging therapeutic target for cardiovascular disease

Riddell

McBride

Braun

et al. 2020

Cardiovascular Research

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Runt-related transcription factor-1 (RUNX1), also known as acute myeloid leukaemia 1 protein (AML1), is a member of the core-binding factor family of transcription factors which modulate cell proliferation, differentiation, and survival in multiple systems. It is a master-regulator transcription factor, which has been implicated in diverse signalling pathways and cellular mechanisms during normal development and disease. RUNX1 is best characterized for its indispensable role for definitive haematopoiesis and its involvement in haematological malignancies. However, more recently RUNX1 has been identified as a key regulator of adverse cardiac remodelling following myocardial infarction. This review discusses the role RUNX1 plays in the heart and highlights its therapeutic potential as a target to limit the progression of adverse cardiac remodelling and heart failure.

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“…Thyroid dysfunction could in uence a wide range of visual pathways, including retina cone opsin expression [8] , myelination in optic nerve [9][10][11] , and visual gyrus [12,13] . Besides, abnormal limbic regions caused by dysfunction of thyroid are mostly temporal and frontal lobes [36,37] , which is consistent with our ndings.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous studies have reported that thyroid dysfunction impacts a wide range of optic pathways in adults, involving the retinal cone [8] , myelination in optic nerve [9][10][11] , and visual gyrus [12,13] . Primary hypothyroidism has signi cantly increased the risk of open-angle glaucoma [14] , which eventually results in visual eld defects [15] .…”

Section: Introductionmentioning

confidence: 99%

Voxel-Based Morphometric Features of Dysthyroid Optic Neuropathy

Tu¹,

Chen²,

Mao³

et al. 2020

Preprint

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Background: Dysthyroid optic neuropathy (DON) is a serious complication of thyroid-associated ophthalmology (TAO), leading to loss of vision or blindness. Numerous studies had reported thyroid dysfunction affects a wide range of visual pathways in adults, from the retina to the visual center. We aimed to explore if there were abnormalities of gray matter density (GMD) in DON patients.Methods: We collected patients with TAO from The Eye Hospital of Wenzhou Medical University. All patients underwent routine ophthalmic examination, Clinical Activity Score (CAS), intraocular pressure (IOP), exophthalmos, visual field, OCT,and orbital CT scan. 16 patients with DON and 16 patients without DON (N-DON) were enrolled in this study. Age, gender, orbital congestion index and degree of education of patients were matched between the two groups. High-resolution magnetization-prepared rapid acquisition with gradient echo (MPRAGE) scans was performed on all patients. Voxel-based morphometry (VBM) was applied to analyze the T1 weighted images of the brain, based on functional magnetic resonance imaging (FMRI) integrated VBM (FSL-VBM).Results: GDM was significantly decreased in the right middle temporal gyrus, left middle frontal gyrus, left superior frontal gyrus, and right middle frontal orbicular gyrus in the DON when compared to N-DON.Conclusions: The DON can result in reduced GMD in specific areas of the brain. This finding suggests that there may be other mechanisms in Don

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Quiescence of adult oligodendrocyte precursor cells requires thyroid hormone and hypoxia to activate Runx1

Cited by 15 publications

References 71 publications

Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages

Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages

RUNX1: an emerging therapeutic target for cardiovascular disease

Voxel-Based Morphometric Features of Dysthyroid Optic Neuropathy

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