Quick treatment with the most appropriate benzodiazepine formulation is vital when treating acute repetitive seizures in the outpatient setting

Abstract

Acute repetitive seizures are a serious epilepsy condition that may progress to status epilepticus. Prompt out-of-hospital treatment is vital and usually involves oral, rectal, intramuscular or intranasal administration of benzodiazepines (e.g. diazepam, midazolam, lorazepam) by nonmedical caregivers. The choice of benzodiazepine and mode of administration should take into account disease severity, patient age, physical condition, individual factors and patient preference.