Quick self-healing and thermo-reversible liposome gel

Rao, Zihe; Inoue, Motoki; Matsuda, Miyuki; Taguchi, Tetsushi

doi:10.1016/j.colsurfb.2010.08.038

Cited by 67 publications

(53 citation statements)

References 36 publications

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“…8A and B). 120, 121 Two good examples of thermo-triggered gelation that have been reported recently are illustrated by biocompatible and biodegradable polymers, poly(ethylene glycol)-b-poly(serinol hexamethylene urethane) (ESHU) and its derivative poly(ethylene glycol)-b-poly(propanol serinate hexamethylene urethane) (EPSHU). 120, 123 Here, the hydrophobic block, poly(serinol hexamethylene urethane) or poly(propanol serinate hexamethylene urethane), is balanced with a hydrophilic PEG block on their chain ends.…”

Section: Hydrophobic Interaction-based Hydrogelsmentioning

confidence: 99%

“…8B). 121 Liposome has been widely used as a versatile drug delivery vehicle in applications ranging from chemotherapy to gene therapy. 126 However, administration of the dispersed particles to a localized site in the body remains a challenge.…”

Section: Hydrophobic Interaction-based Hydrogelsmentioning

confidence: 99%

“…To expand the applications of the liposome delivery platform, a liposome gel was designed by mixing the liposome suspension with a hydrophobic segment end-capped polymer, e.g., cholesterol-end capped PEG (Chol-PEG-Chol). 121 When Chol-PEG-Chol is mixed with a liposome suspension, the hydrophobic ends of cholesterol are separately embedded into the liposome bilayers via hydrophobic interaction to bridge the adjacent liposome particles to yield a network structure. The interactions between the polymer ends and liposome particles have three categories, including the above-mentioned “bridge” between adjacent particles, “loop” when both cholesterol ends are inserted into the same bilayer and “dangling” when only one end is embedded into the liposome bilayer (Fig.…”

Section: Hydrophobic Interaction-based Hydrogelsmentioning

confidence: 99%

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Weak bond-based injectable and stimuli responsive hydrogels for biomedical applications

Ding

Wang

2017

J. Mater. Chem. B

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Here we define hydrogels crosslinked by weak bonds as physical hydrogels. They possess unique features including reversible bonding, shear thinning and stimuli-responsiveness. Unlike covalently crosslinked hydrogels, physical hydrogels do not require triggers to initiate chemical reactions for in situ gelation. The drug can be fully loaded in a pre-formed hydrogel for delivery with minimal cargo leakage during injection. These benefits make physical hydrogels useful as delivery vehicles for applications in biomedical engineering. This review focuses on recent advances of physical hydrogels crosslinked by weak bonds: hydrogen bonds, ionic interactions, host-guest chemistry, hydrophobic interactions, coordination bonds and π-π stacking interactions. Understanding the principles and the state of the art of gels with these dynamic bonds may give rise to breakthroughs in many biomedical research areas including drug delivery and tissue engineering.

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Section: Hydrophobic Interaction-based Hydrogelsmentioning

confidence: 99%

Section: Hydrophobic Interaction-based Hydrogelsmentioning

confidence: 99%

Section: Hydrophobic Interaction-based Hydrogelsmentioning

confidence: 99%

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Weak bond-based injectable and stimuli responsive hydrogels for biomedical applications

Ding

Wang

2017

J. Mater. Chem. B

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“…The Chol-PEG-Chol was prepared from diamino-polyethylene glycol and cholesteryl chloroformate following the procedure of Ref. [19].…”

Section: Materials and Preparationsmentioning

confidence: 99%

Mixture of cholesterol end-capped polyethylene glycol with DSPC liposomal

Sharifi

2015

Opt. Spectrosc.

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The dynamic of network of self-assembled liposome by end-capped polymer was investigated using dynamic light scattering. The liposome network, physically cross-linked by mixed liposome solutions with three different length scale of cholesterol end-capped polyethylene glycol. The network of liposome is dependent on both the polymer concentration and length scale. In the pure liposome, one motion at low time scale is observed by DLS. In the higher concentration of polymer in liposome, several motion is observed that the fast motion is alpha relaxation and other two slow motion are beta and gamma relaxations. The distance between diffusion coefficient of fast and slow relaxation is increased with increase of length scale of endcapped polymers. The SAXS data is fitted with a Percus-Yevick hard sphere model and it shows that the size of liposome increasing with increase of polymer length scale in the mixture system.

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“…Meier et al [66] reported that a PEG derivative capped with cholesteryl groups can function as a physical crosslinker of vesicles and cells. It was also reported that the crosslinking of liposomes with this PEG derivative enables rapid recovery, even after 1000% strain [69]. Taguchi and co-worker [70] prepared dioleoyl PEG, which can physically crosslink pancreatic beta cells by a hydrophobic interaction.…”

Section: Hydrophobic Interactionmentioning

confidence: 99%

Assembly of cells and vesicles for organ engineering

Taguchi

2011

Science and Technology of Advanced Materials

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The development of materials and technologies for the assembly of cells and/or vesicles is a key for the next generation of tissue engineering. Since the introduction of the tissue engineering concept in 1993, various types of scaffolds have been developed for the regeneration of connective tissues in vitro and in vivo. Cartilage, bone and skin have been successfully regenerated in vitro, and these regenerated tissues have been applied clinically. However, organs such as the liver and pancreas constitute numerous cell types, contain small amounts of extracellular matrix, and are highly vascularized. Therefore, organ engineering will require the assembly of cells and/or vesicles. In particular, adhesion between cells/vesicles will be required for regeneration of organs in vitro. This review introduces and discusses the key technologies and materials for the assembly of cells/vesicles for organ regeneration.

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Quick self-healing and thermo-reversible liposome gel

Cited by 67 publications

References 36 publications

Weak bond-based injectable and stimuli responsive hydrogels for biomedical applications

Weak bond-based injectable and stimuli responsive hydrogels for biomedical applications

Mixture of cholesterol end-capped polyethylene glycol with DSPC liposomal

Assembly of cells and vesicles for organ engineering

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