Quick, non-invasive and quantitative assessment of small fiber neuropathy in patients receiving chemotherapy

Saad, Mehdi; Psimaras, Dimitri; Tafani, C.; Sallansonnet-Froment, M.; Calvet, J; Vilier, Alice; Tigaud, Jean-Marie; Bompaire, Flavie; Lebouteux, M.; Greslan, T. De; Ceccaldi, B.; Poirier, J; Ferrand, François‐Régis; Moulec, Sylvestre Le; Huillard, Olivier; Goldwasser, François; Taillia, H.; Maisonobe, Thierry; Ricard, Damien

doi:10.1007/s11060-015-2049-x

Cited by 26 publications

(40 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The onset of OIPN remaining unpredictable, new insights into OIPN assessment are needed to detect and prevent more effectively this side effect. In this context, Sudoscan is being assessed to test its opportunity in OIPN diagnosis [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is interesting to notice that ESC is fully objective whereas NPSI score is fully subjective. In the same way, there was a relationship between ESC and another subjective score, the Total Neuropathy Score (TNSc), in oxaliplatin-treated patients [ 18 ]. In Novak et al study, ESC failed to correlate with NPSI score [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Saad et al report potential interest of Sudoscan® technology (Impeto Medical, Paris, France) in OIPN assessment [ 18 ]. The Sudoscan device is a quantitative assessment of small fiber neuropathy and the technology is based on Electrochemical Skin Conductance (ESC) measurement in palm and sole [ 16 , 18 , 19 ]. In small fiber neuropathy, sweat glands are underinnervated and sweat function is altered.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Electrochemical Skin Conductance as a Marker of Painful Oxaliplatin-Induced Peripheral Neuropathy

Delmotte¹,

Tutakhail

Abdallah³

et al. 2018

Neurology Research International

View full text Add to dashboard Cite

Purpose Oxaliplatin is a platinum compound widely used in gastrointestinal cancer treatment but produces dose-limiting peripheral neuropathy. New insights into oxaliplatin-induced peripheral neuropathy (OIPN) assessment are needed to detect more effectively this condition. In this context, we conducted Canaloxa study, a prospective preliminary clinical trial that aimed to investigate how Electrochemical Skin Conductance (ESC), a parameter used in small fiber neuropathy assessment, could be helpful in OIPN diagnosis. Methods Cancer patients treated for at least three months with oxaliplatin and suffering from clinically OIPN were included. Electrochemical Skin Conductance, thermal thresholds, and neuropathic pain were assessed in all included patients. Results During one year, 36 patients were included. The main result was the correlation between ESC and Neuropathic Pain Symptom Inventory score for hands (rho value = -0.69, p < 0.0001) and feet (rho value = -0.79, p < 0.0001). ESC values were lower in neuropathic patients with painful symptoms than in ones without painful symptoms (p = 0.0003 and p < 0.0001 for hands and feet, respectively). No correlation was observed between ESC and thermal thresholds. Conclusion These preliminary data suggest that ESC could be a useful objective marker of painful oxaliplatin-induced neuropathy and could complement the use of subjective clinical scales. This study was prospectively registered on clinicaltrials.gov (NCT02827916) before patient recruitment has begun.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Electrochemical Skin Conductance as a Marker of Painful Oxaliplatin-Induced Peripheral Neuropathy

Delmotte¹,

Tutakhail

Abdallah³

et al. 2018

Neurology Research International

View full text Add to dashboard Cite

show abstract

“…This study supported the use of Sudoscan to assess small fibre neuropathy in patients receiving chemotherapy, but results were too preliminary and obtained just from a single setting to be generalised. 39 To date, there is little evidence to support the use of ANS testing in CIPN, as they yield inferior sensitivity than NCS. Moreover, there are well-known confounders affecting the interpretation of autonomic testing, including age, paraneoplastic involvement and precancer comorbidities, such as diabetes and heart disease.…”

Section: Autonomic Function Studiesmentioning

confidence: 99%

Neurophysiological, nerve imaging and other techniques to assess chemotherapy-induced peripheral neurotoxicity in the clinical and research settings

Park

Islam

Tamburin

et al. 2019

J Neurol Neurosurg Psychiatry

Self Cite

View full text Add to dashboard Cite

Chemotherapy-induced peripheral neurotoxicity (CIPN) is a common dose-limiting side effect of several anticancer medications. CIPN may involve multiple areas of the peripheral nervous system from the autonomic and dorsal root ganglia (DRG) to the axon and any peripheral nerve fibre type. Large diameter sensory myelinated (Aβ) fibres are more frequently involved, but motor, small myelinated (Aδ), unmyelinated (C) or autonomic fibres may also be affected. Here, we review the current evidence on techniques for the CIPN assessment in the clinical and experimental settings. Nerve conduction studies (NCS) may be used at the subclinical and early CIPN stage, to assess the extent of large nerve fibre damage and to monitor long-term outcomes, with the sural or dorsal sural nerve as the most informative. The quantitative sensory neurological examination provides valuable data alongside NCS. Quantitative sensory testing and nerve excitability studies add information regarding pathophysiology. Nerve MRI and ultrasound may provide information on enlarged nerve, increased nerve signal intensity and DRG or spinal cord changes. Skin biopsy, corneal confocal microscopy, laser-evoked potentials, contact heat-related potentials and microneurography may reveal the extent of damage to small unmyelinated nerve fibres that go undetected by NCS. The information on the role of these latter techniques is preliminary. Hence, the use of multimodal testing is recommended as the optimal CIPN assessment strategy, employing objective NCS and other specialised techniques together with subjective patient-reported outcome measures.

show abstract

“…SUDOSCAN is a simple, noninvasive method [21–23], and various studies have validated its efficacy in both detecting diabetic peripheral neuropathy (DPN) and CAN screening [12, 15, 21]. In this study, we have demonstrated that ESC of the hands and feet were correlated with CAN-RS (HESC, r = −0.342; FESC, r = −0.496, P < 0.001), and also correlated with resting to standing blood pressure difference (HESC, r = −0.192, P < 0.001; FESC, r = −0.135, P = 0.014) in CARTs (these results are not shown in Section 3).…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Cardiovascular Autonomic Dysfunction and Ocular Abnormality in Chinese T2DM

Wang

Shen

Wu³

et al. 2017

Journal of Diabetes Research

View full text Add to dashboard Cite

Objective This study aims to explore the relationship between autonomic nerve dysfunction—assessed by cardiovascular autonomic neuropathy risk score (CAN-RS)—and ocular abnormality in Chinese type 2 diabetes mellitus (T2DM). Method This is a cross-sectional study. A total of 335 subjects with T2DM were enrolled. The state of visual acuity, the lens, the vitreous, and the fundus were tested by professional ophthalmic instruments. The electrochemical skin conductance (ESC) of the hands and feet was measured by SUDOSCAN, from which a cardiovascular autonomic neuropathy risk score (CAN-RS) was calculated. Receiver operating characteristic (ROC) curves were drawn to evaluate the feasibility and accuracy of CAN-RS in diabetic oculopathy screening. Results Abnormalities of the lens, vitreous, and fundus accounted for 7.8%, 5.1%, and 9.9%, respectively, in this study. The means of hands and feet ESC were higher than 60 μS, and CAN-RS was 33.1 ± 14.8%. In logistic regression analysis, CAN-RS was positively associated with lens (OR = 1.055, P < 0.001) and vitreous (OR = 1.044, P < 0.01) abnormality. The area under ROC to detect lens and vitreous abnormality was 0.713 and 0.725, respectively. Conclusion CAN-RS, a cardiac autonomic nerve dysfunction index calculated by SUDOSCAN, may be a promising index for lens and vitreous abnormality screening in T2DM patients. Further studies are needed to confirm the conclusion.

show abstract

Quick, non-invasive and quantitative assessment of small fiber neuropathy in patients receiving chemotherapy

Cited by 26 publications

References 39 publications

Electrochemical Skin Conductance as a Marker of Painful Oxaliplatin-Induced Peripheral Neuropathy

Electrochemical Skin Conductance as a Marker of Painful Oxaliplatin-Induced Peripheral Neuropathy

Neurophysiological, nerve imaging and other techniques to assess chemotherapy-induced peripheral neurotoxicity in the clinical and research settings

The Relationship between Cardiovascular Autonomic Dysfunction and Ocular Abnormality in Chinese T2DM

Contact Info

Product

Resources

About