Quick dissolving films of nebivolol hydrochloride: formulation and optimization by a simplex lattice design

Parejiya, Punit B.; Patel, Rakshit; Mehta, Dharmik M.; Shelat, Pragna K.; Barot, Bhavesh S.

doi:10.1007/s40005-013-0080-5

Cited by 22 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Final film solution casting on a standard petridish for defoaming. It is dried in hot air oven at 40 ºC for 3 h. The film was carefully removed from the petridish, checked for any imperfections and cut into the required size to deliver the equivalent dose (2x2 cm 2 ) per strip 20,21 . The samples were stored in desiccators at relative humidity 30-35 % until further analysis.…”

Section: Methods: Preparation Of Fast Dissolving Film By Solventmentioning

confidence: 99%

Untitled

2018

IJPSR

View full text Add to dashboard Cite

The present investigation was to formulation and development of fast dissolving mucoadhesive buccal film of nebivolol by using solvent casting method. Nebivolol is a third-generation cardio selective β1-blocker undergoes extensive metabolism in the liver, gastrointestinal disturbance, abdominal pain after its oral administration and resulting in to a poor (10-12%) bioavailability. In order to improve the bioavailability, efficacy and to minimize the side effects associated with oral administration. Prepared mucoadhesive buccal films using HPMC E15 and PVP as mucoadhesive polymers. Among the two polymers used HPMC E15 showed an increased in-vitro residence time due to high mucoadhesive property. Mucoadhesive buccal films were evaluated by weight variation, thickness, folding endurance, pH, in-vitro disintegration, in vitro dissolution, tensile strength and drug content. In-vitro drug release study showed that more than 98.19 ± 0.02 % drug was released within 40 min. The tensile strength of formulation SW9 was found 50.00 N/mm 2 . Folding endurance of formulation SW9 was found 149. The disintegration time for formulation SW1 was found to be 79.37 seconds and SW9 was 70.03 seconds respectively. Thus it can be concluded that the prepared formulation of buccal mucoadhesive film can be a novel treatment for myocardial infarction and angina pectoris.

show abstract

Section: Methods: Preparation Of Fast Dissolving Film By Solventmentioning

confidence: 99%

Untitled

2018

IJPSR

View full text Add to dashboard Cite

show abstract

“…A water insoluble drug (piroxicam) was incorporated into fast dissolving films prepared using maltodextrins (MDX) and equivalent low dose dextrose 31 . ODFs of nebivolol HCl prepared from HPMC, pullulan, polyvinyl pyrrolidone (PVP) illustrated that changing polymer concentration profoundly affects mechanical properties and percentage drug release 32 . As polymers govern the release profile, mono-and double-layered buccoadhesive films of chlorhexidine were prepared to portray this fact.…”

Section: Hydrophillic Polymersmentioning

confidence: 99%

Oral Dissolving Films: A Review

Muralidhar,

Narayana

2023

Int J Res Rev

View full text Add to dashboard Cite

Oral dissolving films (ODFs) are thin, flexible, and fast-dissolving sheets that can deliver active substances to the oral cavity. They offer several advantages over conventional oral dosage forms, such as ease of swallowing, precise dosing, improved patient compliance, and rapid onset of action. ODFs can be used for various therapeutic applications, such as anti-ulcer, anti-asthmatic, antihistamine, and analgesic drugs. This review article presents a comprehensive analysis of recent advancements in ODF formulation, manufacturing techniques, and their diverse applications in pharmaceutical, nutraceutical, and biomedical fields. The formulation of ODFs involves the selection of suitable polymers, plasticizers, surfactants, flavours, and sweeteners. The polymers are the main component that determines the mechanical properties, disintegration time, and drug release profile of the films. The plasticizers are added to improve the flexibility and elasticity of the films. The surfactants are used to enhance the solubility and permeability of the drugs. The flavours and sweeteners are used to mask the unpleasant taste of the drugs and improve the palatability of the films. The production methods of ODFs include solvent casting, hot melt extrusion, and roll casting. These methods differ in terms of the equipment, process parameters, and film quality. Each technique's advantages, limitations, and potential for scalability are outlined, providing insight into the critical factors influencing ODF development. In summary, this review article provides a comprehensive overview of the recent progress in ODF technology, encompassing formulation optimization, manufacturing advancements, and innovative applications. As the field of oral dissolving films continues to evolve, this article offers valuable insights for researchers, clinicians, and pharmaceutical industry stakeholders seeking to harness the full potential of this versatile drug delivery platform. Keywords: Oral dissolving films, Plasticizer, Solvent casting method, Hot melt extrusion, Roll casting

show abstract

“…A water insoluble drug (piroxicam) was incorporated into fast dissolving films prepared using maltodextrins (MDX) and equivalent low dose dextrose (Cilurzo et al, 2008). ODFs of nebivolol HCl prepared from HPMC, pullulan, polyvinyl pyrrolidone (PVP) illustrated that changing polymers concentration profoundly affects mechanical properties and percentage drug release (Parejiya et al, 2012). As polymers govern the release profile, mono- and double-layered buccoadhesive films of chlorhexidine were prepared to portray this fact.…”

Section: Formulationmentioning

confidence: 99%

Orally disintegrating films: A modern expansion in drug delivery system

Irfan¹,

Rabel²,

Bukhtar³

et al. 2016

Saudi Pharmaceutical Journal

260

230

View full text Add to dashboard Cite

Over the past few decades, tendency toward innovative drug delivery systems has majorly increased attempts to ensure efficacy, safety and patient acceptability. As discovery and development of new chemical agents is a complex, expensive and time consuming process, so recent trends are shifting toward designing and developing innovative drug delivery systems for existing drugs. Out of those, drug delivery system being very eminent among pediatrics and geriatrics is orally disintegrating films (ODFs). These fast disintegrating films have superiority over fast disintegrating tablets as the latter are associated with the risks of choking and friability. This drug delivery system has numerous advantages over conventional fast disintegrating tablets as they can be used for dysphasic and schizophrenic patients and are taken without water due to their ability to disintegrate within a few seconds releasing medication in mouth. Various approaches are employed for formulating ODFs and among which solvent casting and spraying methods are frequently used. Generally, hydrophilic polymers along with other excipients are used for preparing ODFs which allow films to disintegrate quickly releasing incorporated active pharmaceutical ingredient (API) within seconds. Orally disintegrating films have potential for business and market exploitation because of their myriad of benefits over orally disintegrating tablets. This present review attempts to focus on benefits, composition, approaches for formulation and evaluation of ODFs. Additionally, the market prospect of this innovative dosage form is also targeted.

show abstract

Quick dissolving films of nebivolol hydrochloride: formulation and optimization by a simplex lattice design

Cited by 22 publications

References 14 publications

Untitled

Untitled

Oral Dissolving Films: A Review

Orally disintegrating films: A modern expansion in drug delivery system

Contact Info

Product

Resources

About