“…Sophisticated regulatory networks in Pseudomonads control the physiological responses to these stressful conditions, including both local and global regulators that adjust transcriptional levels according to environmental cues (Tribelli et al, 2013;Balasubramanian et al, 2015;Arce-Rodríguez et al, 2016;Udaondo et al, 2018). Carbon catabolite repression, governed by the Crc protein, is a major player among these regulatory systems in Pseudomonas species (Wolff et al, 1991;Collier et al, 1996;Velázquez et al, 2004;Rojo, 2010;Grenga et al, 2017;Liu et al, 2017;Wirebrand et al, 2018). Crc is a global regulator that exerts its influence at the post-transcriptional level by binding (together with the Hfq protein, the actual RNA-binding protein in the complex) a cognate region of target mRNAs (Kambara et al, 2018), thus blocking translation (Moreno et al, 2009;Milojevic et al, 2013;Moreno et al, 2015).…”