This chapter gives a comprehensive overview of the present status of Integrated Information and Computing Systems for complex use cases and system architectures in order to exploit new resources for opening up new cognitive insights for natural sciences applications. It shows up with the challenges creating complex integrated information and computing components and covers implementation, frameworks, and security issues with these processes and how the overall complexity can be reduced using collaboration frameworks with Distributed and High Performance Computing resources in natural sciences disciplines for building integrated public / commercial information system components within the e-Society. The focus is on using a collaboration framework for integrating computing resources with information system components, interfaces for data and application interchange, based on current developments and embedding development, operational, up to strategical level. Referenced are the case studies within the long-term GEXI project, GISIG framework and Active Source components used in heterogeneous environments. The Collaboration house framework has been created over the last years and is being used for a number of scenarios in research environments, using High End Computing resources. The application of these methods for commercial service structures affords the consideration of various legal, security, and trust aspects. This has already been used by international partners from geosciences, natural sciences, industry, economy, and education though this concept has been found a solution for the component integration and cooperation for information systems, e.g., in natural sciences and archaeology. Nevertheless the different aspects and situations need to be collected in order to provide and disseminate them for wider use. Examples are Envelope Interfaces for geoscientific processing, from advanced scientific computing up to High Performance Computing and Information Systems as well as enabling object security and verification for Integrated Information and Computing Systems.