Quetiapine-induced priapism

Abstract

Priapism is a urologic emergency characterized by a prolonged, persistent, and painful penile erection in the absence of sexual stimulation. The reports indicate that several conditions can cause priapism such as psychotropic medication. One of the mechanisms by which antipsychotics are believed to induce priapism is through alpha 1-antagonism. This case is of a 28-year-old male with a history of bipolar disorder with priapism related to quetiapine. In this case, the treatment of priapism includes discontinuation of the offending agent and drainage of the corpus cavernosum twice a day along with intracavernosal phenylephrine injections. Previous episodes of medication-induced priapism may increase the risk of priapism in patients afterwards. It is important to inform patients about the priapism that may occurs as a side effect of medications.

Antipsychotic Drugs and Peripheral Edema: A Review

“…Antipsikotikler (AP), şizofreni gibi psikotik bozukluklarda, bipolar bozukluk akut dönem tedavisinde, şiddetli anksiyete bozukluklarında ve depresif durumlarda kullanılan ilaçlardır (13,14) (18,19). BKAP'ların yaptığı pek çok yan etkiyi yapmamasına rağmen, uyku ve iştah artışı, şişmanlık, üreme işlevlerinde bozulma gibi yan etkileri görülür (19,20).…”