Quetiapine for the treatment of borderline personality disorder; an open-label study

Thrombocytopenia with quetiapine: two case reports, one with positive rechallenge

“…Quetiapine was added at 50 mg/day, while mirtazapine was reduced to 30 mg/day. Laboratory tests carried out the following day and 5 days after the start of treatment with quetiapine revealed platelet counts of 100,000/mm 3 and 56,000/mm 3 respectively. Two further measurements were obtained, 8 days and 28 days after discontinuing treatment with quetiapine, showing higher platelet levels of 85,000/mm 3 and 120,000/mm 3 respectively.…”

“…Accordingly, the relative risk of thrombocytopenia can be described as very rare with loxapine and clozapine (o 0.01%), uncommon with risperidone (X 0.1%, o 1%), but very common with quetiapine (X 10%). However, very few cases are reported in the literature, [1][2][3][4] with one published case of idiopathic thrombocytopenic purpura, 1 and it remains unclear whether rechallenge may be considered.…”

“…During her hospitalization, aripiprazole was stopped and quetiapine 50 mg/day was introduced. Tests performed 3 months after initiating treatment with quetiapine were notable for a platelet count of 107,000/mm 3 . Six days later, a second test was carried out, and the platelet count was down to 95,000/mm 3 .…”

“…Tests performed 3 months after initiating treatment with quetiapine were notable for a platelet count of 107,000/mm 3 . Six days later, a second test was carried out, and the platelet count was down to 95,000/mm 3 . Treatment with quetiapine was suspended for 3 days, following which the platelet count went back up to 120,000/mm 3 .…”

“…Six days later, a second test was carried out, and the platelet count was down to 95,000/mm 3 . Treatment with quetiapine was suspended for 3 days, following which the platelet count went back up to 120,000/mm 3 . The psychiatrist reintroduced quetiapine and scheduled a control platelet test 5 days later, which showed a decrease to 84,000/mm 3 .…”