Quetiapine and Norquetiapine Serum Concentrations and Clinical Effects in Depressed Patients Under Augmentation Therapy With Quetiapine

Haji, Elnaz Ostad; Wagner, Stefanie; Fric, Mirijam; Laux, Gerd; Pittermann, P.; Röschke, Joachim; Hiemke, Christoph

doi:10.1097/ftd.0b013e31828d221f

Cited by 7 publications

(3 citation statements)

References 20 publications

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“…A study in Denmark by Hasselstrøm & Linnet 24 also used TDM data for 62 patients and revealed a median Cps/DD ratio of 0.41 nmol/L/mg (0.16 ng/ml/mg) for quetiapine (all IR). Ostad Haji et al 32 reported the mean Cps/DD ratio of quetiapine (43 IR) as 0.34 ± 0.24 ng/ml/mg in 105 depressive patients by the mean DD of 222 ± 125 mg.…”

Section: Discussionmentioning

confidence: 99%

Post‐therapy plasma concentrations of quetiapine in Taiwanese patients

Huang

Chen

Lin

2023

Neuropsychopharm Rep

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Quetiapine is a second-generation antipsychotic used for the treatment of schizophrenia and bipolar disorder and as an adjunct treatment for major depressive disorder. Quetiapine has both immediate-release (IR) and extended-release (ER) forms. The recommended daily dose (DD) of IR quetiapine for schizophrenia is 150-750 mg, administered twice or thrice daily. The recommended DD of ER quetiapine is 400-800 mg. Quetiapine is also approved for the treatment of bipolar mania as either monotherapy or adjunct therapy and for the treatment of bipolar depression as monotherapy, with the recommended DDs being 400-800 and 300-600 mg, respectively. Additionally,

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Section: Discussionmentioning

confidence: 99%

Post‐therapy plasma concentrations of quetiapine in Taiwanese patients

Huang

Chen

Lin

2023

Neuropsychopharm Rep

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“…Both were assessed in patients autopsied in the study of Vignali et al The authors found (peripheral) blood levels of norquetiapine to be 258.93 (95% CI = −22.63–540.48). Blood levels of 7-hydroxy quetiapine were 45.88 (95% CI = −8.24–83.52) [ 22 , 45 ].…”

Section: Relevant Matricesmentioning

confidence: 99%

“…Non-toxic levels in postmortem blood extend to around 0.8 mg/kg, but, at the same time, toxic levels in postmortem blood can begin at 0.35 mg/kg. The serum or plasma of quetiapine overdose survivors had concentrations ranging from 1 to 10 mg/L [ 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Quetiapine-Related Deaths: In Search of a Surrogate Endpoint

Šoša

2024

Toxics

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Quetiapine is a second-generation antipsychotic drug available for two and half decades. Due to increased misuse, prescription outside the approved indications, and availability on the black market, it is being encountered in medicolegal autopsies more frequently. For instance, it has been linked to increased mortality rates, most likely due to its adverse effects on the cardiovascular system. Its pharmacokinetic features and significant postmortem redistribution challenge traditional sampling in forensic toxicology. Therefore, a systematic literature review was performed, inclusive of PubMed, the Web of Science—core collection, and the Scopus databases; articles were screened for the terms “quetiapine”, “death”, and “autopsy” to reevaluate each matrix used as a surrogate endpoint in the forensic toxicology of quetiapine-related deaths. Ultimately, this review considers the results of five studies that were well presented (more than two matrices, data available for all analyses, for instance). The highest quetiapine concentrations were usually measured in the liver tissue. As interpreted by their authors, the results of the considered studies showed a strong correlation between some matrices, but, unfortunately, the studies presented models with poor goodness of fit. The distribution of quetiapine in distinct body compartments/tissues showed no statistically significant relationship with the length of the postmortem interval. Furthermore, this study did not confirm the anecdotal correlation of peripheral blood concentrations with skeletal muscle concentrations. Otherwise, there was no consistency regarding selecting an endpoint for analysis.

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