Questionnaire survey of satisfaction with medication for five symptom domains of dementia with Lewy bodies among patients, their caregivers, and their attending physicians

Abstract

BackgroundThe real‐world status of satisfaction with medication for dementia with Lewy bodies (DLB) has not been elucidated. We assessed the satisfaction of patients with DLB, their caregivers, and their attending physicians (trios) with medication according to the clinical symptom domains of DLB.MethodsThis was a subanalysis of a cross‐sectional, questionnaire‐based, survey study of trios. The subanalysis set comprised analysis populations for cognitive impairment, parkinsonism, psychiatric symptoms, sleep‐related disorders, and autonomic dysfunction (orthostatic hypotension, constipation, and dysuria). These analysis populations included trios of patients who had any symptom domain and took medication for each symptom domain, and for which all trio data on satisfaction with medication for the symptom domain were available. The degrees of satisfaction with medication were classified as ‘satisfied’, ‘neutral’, or ‘dissatisfied’.ResultsThe analysis set for this study included 110 trios for cognitive impairment, 62 for parkinsonism, 47 for psychiatric symptoms, 29 for sleep‐related disorders, none for orthostatic hypotension, 11 for constipation, and seven for dysuria. There were no statistically significant differences in the degree of satisfaction with medication for symptom domains other than parkinsonism and dysuria between patients–caregivers, patients–physicians, and caregivers–physicians. Regarding satisfaction with medication for parkinsonism, significantly more physicians than patients answered ‘satisfied’ (75.8% vs. 51.6%), and significantly more patients than physicians answered ‘neutral’ (35.5% vs. 14.5%) (P = 0.013). Regarding satisfaction with medication for dysuria, significantly more caregivers than physicians answered ‘satisfied’ (100% vs. 28.6%, P = 0.038).ConclusionsSatisfaction with medication for symptom domains other than parkinsonism and dysuria was similar among trios. Our results suggest that physicians should pay more attention to patients' satisfaction with medication for parkinsonism, and to caregivers' satisfaction with medication for dysuria to help prevent undermedication.

Eating problems in people with dementia with Lewy bodies: Associations with various symptoms and the physician’s understanding

“…Details of the initial study design have been reported previously (Hashimoto et al, 2022;Toya et al, 2023). This was a multicenter, crosssectional, observational survey study that included participants with DLB, their caregivers, and their attending physicians as study participants.…”