Quercetin treatment increases H2O2 removal by restoration of endogenous antioxidant activity and blocks isoproterenol-induced cardiac hypertrophy

Alexandre, Joana Varlla de Lacerda; Viana, Yuana Ivia Ponte; David, Cícera Edna Barbosa; Cunha, Pedro Lourenzo Oliveira; Albuquerque, Amanda Cabral; Varela, Anna Lídia Nunes; Kowaltowski, Alicia J.; Facundo, Heberty T.

doi:10.1007/s00210-020-01953-8

Cited by 18 publications

(19 citation statements)

References 30 publications

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“…According to Nijveldt et al, flavonoids exhibit strong cell protection against ROS through different working mechanisms including an increase in the function of endogenous antioxidants ( 46 ). First, flavonoids can work as direct radical scavengers being oxidized by radicals because of the high reactivity of the OH group of the flavonoids; hence a radical molecule becomes more stable and inactive; an example of these are rutin ( 48 ), luteolin, and quercetin ( 49 , 50 ); all of them are found in this study. Second, NO · plays a significant role in molecular events involved in neurodegenerative diseases, promoting neuronal death through oxidative damage on cellular lipids, proteins, and ADN ( 51 ); therefore, flavonoids are able to remove the overconcentration of NO · radicals ( 46 , 52 , 53 ).…”

Section: Resultsmentioning

confidence: 70%

Neuroprotective Potential of Tamarillo (Cyphomandra betacea) Epicarp Extracts Obtained by Sustainable Extraction Process

et al. 2021

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Tamarillo (Cyphomandra betacea (Cav.) Sendt.), or tree tomato, is a tropical fruit from the Andean region of South America; it is highly rich in vitamins, minerals, and polyphenolic compounds. In this study, extracts from tamarillo epicarp (TE) were obtained by pressurized liquid extraction (PLE), and their in-vitro neuroprotective potential was assessed. A central composite design with response surface methodology was performed to optimize PLE as a function of solvent composition and temperature. Selected response variables were extraction yield, total phenolic content (TPC), total flavonoid content (TFC), total carotenoid content (TCC), antioxidant (ABTS), and anti-inflammatory (LOX) activities, and anti-acetylcholinesterase (AChE) inhibitory capacity. According to the desirability function, the optimal conditions were 100% ethanol and 180°C with a 0.87 desirability value. Next, the anti-butyrylcholinesterase enzyme (BChE), reactive oxygen species (ROS), and reactive nitrogen species (RNS) inhibition as well as cytotoxicity in HK-2, THP-1 monocytes, and SH-5YSY neuroblastoma cell lines were studied for the TE extract obtained under optimized conditions. The optimum TE extract provided the following results: extraction yield (36.25%), TPC (92.09 mg GAE/g extract), TFC (4.4 mg QE/g extract), TCC (107.15 mg CE/g extract), antioxidant capacity (ABTS, IC50 = 6.33 mg/ml extract), LOX (IC50 = 48.3 mg/ml extract), and AChE (IC50 = 97.46 mg/ml extract), and showed no toxicity at concentration up to 120 μg/ml extract for all the tested cell lines. Finally, chemical characterization by liquid chromatography-tandem mass spectrometry (UHPLC-q-TOF-MS/MS) of the optimum TE extract exhibited an important presence of hydroxycinnamic acid derivatives and other phenolic acids as well as quercetin hexoside and rutin, as main metabolites responsible for the observed biological properties. All these results suggested that TE, which represents between 8 and 15% of the total fruit, could become a promising natural by-product with a potential “multitarget” activity against Alzheimer's disease.

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Section: Resultsmentioning

confidence: 70%

Neuroprotective Potential of Tamarillo (Cyphomandra betacea) Epicarp Extracts Obtained by Sustainable Extraction Process

et al. 2021

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“…According to Nijveldt et al, flavonoids exhibit strong cell protection against ROS through different working mechanisms including an increase in the function of endogenous antioxidants (46). First, flavonoids can work as direct radical scavengers being oxidized by radicals because of the high reactivity of the OH group of the flavonoids; hence a radical molecule becomes more stable and inactive; an example of these are rutin (48), luteolin, and quercetin (49,50); all of them are found in this study. Second, NO • plays a significant role in molecular events involved in neurodegenerative diseases, promoting neuronal death through oxidative damage on cellular lipids, proteins, and ADN (51); therefore, flavonoids are able to remove the overconcentration of NO • radicals (46,52,53).…”

Section: Effect Of Extraction Conditions On Abts Lox and Ache Activities Correlation With Tpc Tfc And Tcc Antioxidant Activitysupporting

confidence: 55%

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“…Further, isoproterenol alone resulted in a significant increase in cardiac NF-κB signaling, pro-inflammatory cytokine release, and a dramatic decline in catalase, SOD, and reduced glutathione, all of which were reversed by malvidin-3-glucoside [126]. These βAR-antagonistic effects are consistent with other polyphenols in isoproterenol-induced HF, as observed with gallic acid [127], quercetin [128] and resveratrol [129].…”

Section: Berry Polyphenols As Adrenergic Receptor Inhibitorsmentioning

confidence: 70%

“…βAR ↓ [125][126][127][128][129] Blueberries, malvidin, gallic acid, quercetin, resveratrol and syringic acid.…”

Section: Clinical Effects Of Berries: Implications In Cmdmentioning

confidence: 99%

Berries and Their Polyphenols as a Potential Therapy for Coronary Microvascular Dysfunction: A Mini-Review

Najjar

Schwartz

Wong

et al. 2021

IJMS

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Ischemia with no obstructive coronary artery disease (INOCA) is a common diagnosis with a higher prevalence in women compared to men. Despite the absence of obstructive coronary artery disease and no structural heart disease, INOCA is associated with major adverse cardiovascular outcomes as well a significant contributor to angina and related disability. A major feature of INOCA is coronary microvascular dysfunction (CMD), which can be detected by non-invasive imaging and invasive coronary physiology assessments in humans. CMD is associated with epicardial endothelial-dependent and -independent dysfunction, diffuse atherosclerosis, and left-ventricular hypertrophy, all of which lead to insufficient blood flow to the myocardium. Inflammatory and oxidative stress signaling, upregulation of the renin-angiotensin-aldosterone system and adrenergic receptor signaling are major drivers of CMD. Treatment of CMD centers around addressing cardiovascular risk factors; however, there are limited treatment options for those who do not respond to traditional anti-anginal therapies. In this review, we highlight the ability of berry-derived polyphenols to modulate those pathways. The evidence supports the need for future clinical trials to investigate the effectiveness of berries and their polyphenols in the treatment of CMD in INOCA patients.

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Quercetin treatment increases H2O2 removal by restoration of endogenous antioxidant activity and blocks isoproterenol-induced cardiac hypertrophy

Cited by 18 publications

References 30 publications

Neuroprotective Potential of Tamarillo (Cyphomandra betacea) Epicarp Extracts Obtained by Sustainable Extraction Process

Neuroprotective Potential of Tamarillo (Cyphomandra betacea) Epicarp Extracts Obtained by Sustainable Extraction Process

Data_Sheet_1.pdf

Berries and Their Polyphenols as a Potential Therapy for Coronary Microvascular Dysfunction: A Mini-Review

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