Quercetin suppresses NLRP3 inflammasome activation and attenuates histopathology in a rat model of spinal cord injury

Jiang, Wu; Huang, Ya-Ching; Han, Ning; He, Fangping; Li, M; Bian, Zhenyu; Liu, J; Sun, Tiansheng; Zhu, Liangliang

doi:10.1038/sc.2015.227

Cited by 77 publications

(55 citation statements)

References 39 publications

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“…NLRP3 inflammasome promotes diabetes‐induced endothelial inflammation and atherosclerosis . Studies have reported that quercetin inhibits NLRP3 inflammatory activation in a rat spinal cord injury model . Targeting adjustment of the NLRP3 inflammasome protect the nerve damage in spinal cord injury rats .…”

Section: Introductionmentioning

confidence: 99%

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Quercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in db/db mice

Tian

Lü

Shi

et al. 2020

J Cellular Molecular Medi

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Epidemiological studies have found that diabetes and cognitive dysfunction are closely related. Quercetin has been certified with the effect on improving diabetes mellitus (DM) and cognitive impairment. However, the effect and related mechanism of quercetin on diabetic encephalopathy (DE) are still ambiguous. In this study, we used the db/db mice (diabetic model) to discover whether quercetin could improve DE through the Sirtuin1/NLRP3 (NOD‐, LRR‐ and pyrin domain‐containing 3) pathway. Behavioural results (Morris water maze and new object recognition tests) showed that quercetin (70 mg/kg) improved the learning and memory. Furthermore, quercetin alleviated insulin resistance and the level of fasting blood glucose. Besides, Western blot analysis also showed that quercetin increased the protein expressions of nerve‐ and synapse‐related protein, including postsynapticdensity 93 (PSD93), postsynapticdensity 95 (PSD95), brain‐derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the brain of db/db mice. Quercetin also increased the protein expression of SIRT1 and decreased the expression of NLRP3 inflammation‐related proteins, including NLRP3, the adaptor protein ASC and cleaved Caspase‐1, the pro‐inflammatory cytokines IL‐1β and IL‐18. In conclusion, the present results indicate that the SIRT1/NLRP3 pathway may be a crucial mechanism for the neuroprotective effect of quercetin against DE.

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Section: Introductionmentioning

confidence: 99%

“…35 Studies have reported that quercetin inhibits NLRP3 inflammatory activation in a rat spinal cord injury model. 36 Targeting adjustment of the NLRP3 inflammasome protect the nerve damage in spinal cord injury rats. 37 Previous studies have demonstrated that quercetin can up-regulate SIRT1 leading to neuroprotection and improve glycolipid metabolism.…”

mentioning

confidence: 99%

Quercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in db/db mice

Tian

Lü

Shi

et al. 2020

J Cellular Molecular Medi

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“…In flavones, both rutin and its aglycone, quercetin, also exhibited neuroprotective effects against SCI. Intraperitoneally injection of rutin and quercetin reduced production of ROS and proinflammatory mediators, and NLRP3 inflammasome components including NLRP3, ASC, and caspase‐1 in the rats with SCI …”

Section: Health Promoting Potentials Of Dietary Phytochemicalsmentioning

confidence: 99%

“…Intraperitoneally injection of rutin and quercetin reduced production of ROS and proinflammatory mediators, and NLRP3 inflammasome components including NLRP3, ASC, and caspase-1 in the rats with SCI. [108,109] Oxidative stress has emerged as a deleterious factor in IS and a prospective cohort study provides evidence to show the protective effects of higher consumption of fruits and vegetables, in particular cruciferous and green leafy vegetables and citrus fruits, against risk of IS. [110] Anthocyanins belong to a class of flavonoids that are natural water-soluble colorants widely distributed in berries, grapes, and cherries.…”

Section: Flavonoidsmentioning

confidence: 99%

Targeting the NLRP3 Inflammasome in Neuroinflammation: Health Promoting Effects of Dietary Phytochemicals in Neurological Disorders

Hung

Pan

2019

Molecular Nutrition Food Res

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Neurological disorders occur in the central and peripheral nervous system and include Alzheimer's disease, stroke, and spinal cord injury. Activation of the innate immune system inevitably occurs in all forms of neurological disorders. The NOD‐, LRR‐ and pyrin domain‐containing 3 (NLRP3) inflammasome is a multimolecular complex that can sense danger signals associated with neurological disorders. Assembly of the NLRP3 inflammasome promotes caspase‐1‐mediated interleukin‐1β and interleukin‐18 maturation in microglia, where neuroinflammation contributes to neurological disease development and progression. Thus, this review attempts to elucidate the current knowledge regarding NLRP3 inflammasome activation and its crucial role in the pathogenesis of neurological disorders. Recent scientific findings with respect to neuroprotective effects of dietary phytochemicals against NLRP3 inflammasome‐mediated neurological disorders summarized in this review suggest that modulation of the NLRP3 inflammasome assembly by plant‐derived phytochemicals could be a potential strategy for prevention or treatment of neurological disorders.

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“…Similarly, in a collagen-induced model of arthritis, quercetin inhibited inflammasome activation and associated inflammatory induction (Yang et al, 2018). The administration of the polyphenol quercetin prior to spinal cord injury in mice, which similarly decreased NLRP3 mediated cytokine production through the downregulation of ROS (Jiang et al, 2016). In a rat model of diabetes, increased intracellular ROS upregulated the thioredoxin-interacting protein (TXNIP), which facilitates activation of the NLRP3 inflammasome.…”

Section: Grape-derived Polyphenolic Compounds Attenuate Risk Factors mentioning

confidence: 99%

Suppression of Presymptomatic Oxidative Stress and Inflammation in Neurodegeneration by Grape-Derived Polyphenols

et al. 2018

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Neurodegenerative disorders constitute a group of multifaceted conditions characterized by the progressive loss of neurons and synaptic connections consequent to a combination of specific genetic predispositions and stochastic stressors. The neuropathologies observed in both Alzheimer’s and Parkinson’s disease are in part attributed to compounding intrinsic and extrinsic environmental stressors, which we propose may be limited by the administration of specific grape derived phytochemicals and their metabolized derivatives, specifically polyphenols isolated from grape botanicals. Current therapies for neurodegenerative disorders are limited as they solely target the final disease pathologies including behavioral changes, cognitive deficits, proteinopathies and neuronal loss; however, this strategy is not a sustainable approach toward managing disease onset or progression. This review discusses the application of grape derived polyphenols as an adjunctive treatment paradigm for the prevention of neuropathologies associated with Alzheimer’s disease, Parkinson’s disease and Chronic Traumatic Encephalopathy by simultaneously ameliorating two stochastic stressors that facilitate their disease pathologies: inflammation and oxidative stress. The biophysical attributes of grape-derived polyphenols buffer against redox potential dependent peripheral and neuroinflammation and down regulate the activation of inflammasomes in microglia and astrocytes, which could provide a novel mechanism through which grape-derived polyphenols simultaneously suppress risk factors across pathologically distinct neurodegenerative conditions. This approach therefore offers a prophylactic mode, not feasible through current pharmacological agents, to target activity dependent risk factors for neurodegenerative disorders that manifest over an individual’s lifetime.

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Quercetin suppresses NLRP3 inflammasome activation and attenuates histopathology in a rat model of spinal cord injury

Cited by 77 publications

References 39 publications

Quercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in db/db mice

Quercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in db/db mice

Targeting the NLRP3 Inflammasome in Neuroinflammation: Health Promoting Effects of Dietary Phytochemicals in Neurological Disorders

Suppression of Presymptomatic Oxidative Stress and Inflammation in Neurodegeneration by Grape-Derived Polyphenols

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