Quercetin suppressed NADPH oxidase-derived oxidative stress via heme oxygenase-1 induction in macrophages

Quercetin Protects against Lipopolysaccharide-Induced Intestinal Oxidative Stress in Broiler Chickens through Activation of Nrf2 Pathway

“…Previous studies have shown that quercetin could enhance the ARE (antioxidant response element) binding activity and Nrf2-mediated transcription activity to induce NQO1 expression in human HepG2 cells [30]. As found in macrophages, quercetin activated the Kelch-like ECH-associated protein-1(Keap1)-Nrf2 signaling pathway to induce HO-1 expression for protection against oxidative stress and inflammatory responses [10]. Quercetin could effectively inhibit manganese-induced oxidative stress and inflammatory response in neuraltumor epithelialcells (SK-N-MC) in Sprague-Dawley rats though activating HO-1/Nrf2 and inhibiting the NF-κB pathway [31].…”

“…Quercetin (3,3 ,4 ,5,7-pentahydroxyflavone) is a flavonoid that is widely found in several foods, including grains, fruits, vegetables, and tea [8]. Quercetin has anti-inflammatory, anti-oxidant, and anti-apoptosis properties and thus, it recommended as a nutritional supplement for animals [9][10][11][12]. Moreover, quercetin can prevent oxidative stress by scavenging free radicals, removing oxidation products, and stimulating antioxidant enzymes in many animal models [13,14].…”

Ultrasound-Assisted Extraction of Taxifolin, Diosmin, and Quercetin from Abies nephrolepis (Trautv.) Maxim: Kinetic and Thermodynamic Characteristics

“…This compound has been confirmed to have beneficial anticancer effects [17]. Quercetin has also been used in the drug industry because of its inhibitory features in brain lesions [18], suppression of oxidative stress [19], inhibition of mesangial cell proliferation in early diabetic nephropathy [20], etc. Reports revealed that the phenolics from leaves of A. nephrolepis showed antioxidant in vitro [21] and anti-hepatoma in vivo [22].In the past decade, ultrasonication has been of considerable interest as a newly developed reaction accelerator, and the growth of ultrasound-assisted extraction (UAE) as a novel extraction technology has quickly flourished owing its unique advantages [2,23]; numerous practical applications for bioactive compound extraction have been researched and successfully achieved, such as for flavonoids [24,25], anthocyanins [26], glycosides [27], coumarins [28], lignans [29], alkaloids [30], polysaccharides [31], and vegetable oils [32,33].…”

“…This compound has been confirmed to have beneficial anticancer effects [17]. Quercetin has also been used in the drug industry because of its inhibitory features in brain lesions [18], suppression of oxidative stress [19], inhibition of mesangial cell proliferation in early diabetic nephropathy [20], etc. Reports revealed that the phenolics from leaves of A. nephrolepis showed antioxidant in vitro [21] and anti-hepatoma in vivo [22].…”

Effect of Daily Ingestion of Quercetin-Rich Onion Powder for 12 Weeks on Visceral Fat: A Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study

“…Thus, the results suggest that quercetin-rich onion may be beneficial for preventing obesity and improving liver function.Nutrients 2020, 12, 91 2 of 12 including prevention of metabolic syndrome for fresh vegetables, research on and development of various vegetables containing highly functional components is expected.Quercetin is a flavonoid that is abundant in vegetables such as onions and in fruit, tea, and wine [3][4][5]. It exhibits antioxidant [6,7] and antihypertensive effects [8,9]. In a placebo-controlled double-blind parallel-group comparison study for subjects with body mass index (BMI) of ≥25 kg/m 2 , daily intake of tea containing 110 mg quercetin glycoside for 12 weeks significantly decreased visceral fat area (VFA) at weeks 8 and 12 after intake compared to that in the placebo food intake group [10].…”