Quercetin stabilizes apolipoprotein E and reduces brain Aβ levels in amyloid model mice

Zhang, Xilin; Jin, Haixia; Zhong, Li; Wang, Na; Yang, Longyu; Liu, Chia-Chen; Li, Huifang; Wang, Xin; Zhou, Ying; Zhang, Yunwu; Xu, Huaxi; Bu, Guojun; Zhuang, Jinfu

doi:10.1016/j.neuropharm.2016.04.032

Cited by 56 publications

(36 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For the OAQ, mice were fed with heat‐treated AIN‐93G diet supplemented with 0.08% quercetin as described earlier. The above dosage for quercetin was chosen based on findings by the authors as well as other groups . During the 16‐week dietary intervention, mice were free to access diet and water.…”

Section: Methodsmentioning

confidence: 99%

DietaryAdvancedGlycationEnd Products–InducedCognitive Impairment in Aged ICR Mice: Protective Role of Quercetin

Yang

Wang

Feei

et al. 2020

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Scope: Dietary advanced glycation products (dAGEs) have been reported to induce cognitive impairment while quercetin possesses potential neuroprotective effects. The aim is to explore whether dAGEs would induce similar cognitive impairment from both young and aged ICR mice, and the protective effects of quercetin. Methods and results: A total of 32 aged ICR mice (15-month-old) and 16 young ICR mice (3-month-old) are randomly assigned into the following six groups: Young mice control group, young mice fed with AGEs diet group, old mice control group, old mice fed with AGEs diet group, old mice with quercetin supplemented diet group, old mice fed with AGE diet supplemented with quercetin group. Dietary AGEs induced cognitive impairment only in aged, but not in young, ICR mice, while quercetin intervention is capable of reversing dAGEs-induced cognitive dysfunction. This may be since quercetin 1) increased miR-219, miR-15a, and miR-132 expression, inhibited p-ERK1/2, and tau phosphorylation; and 2) improved gut microbiota richness and diversity, inhibited phylum Tenericutes and Proteobacteria, and elevated butyric acid from cecum. Conclusion: Prolonged application of quercetin may be beneficial in the elderly, especially for those with high consumption of dAGEs.

show abstract

Section: Methodsmentioning

confidence: 99%

DietaryAdvancedGlycationEnd Products–InducedCognitive Impairment in Aged ICR Mice: Protective Role of Quercetin

Yang

Wang

Feei

et al. 2020

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

“…In vitro and in vivo studies reported the neuroprotective role of quercetin against Aβ toxicity, showing that this polyphenol determined cell viability increase with a reduction in neuronal oxidative stress [81]. Quercetin seems to inhibit the Aβ plaque aggregation and the formation of neurofibrillary tangles probably increasing the levels of apolipoprotein E, that has a key role in the clearance of Aβ [82]. A study performed in a triple transgenic mouse model of AD showed that quercetin, after three months treatment, was able to reduce the amount of the β-amyloid fibers with improvement of cognitive performances [83].…”

Section: Alzheimer's Diseasementioning

confidence: 99%

Bioactive Polyphenols and Neuromodulation: Molecular Mechanisms in Neurodegeneration

Meo

Valentino²,

Petillo

et al. 2020

IJMS

View full text Add to dashboard Cite

The interest in dietary polyphenols in recent years has greatly increased due to their antioxidant bioactivity with preventive properties against chronic diseases. Polyphenols, by modulating different cellular functions, play an important role in neuroprotection and are able to neutralize the effects of oxidative stress, inflammation, and apoptosis. Interestingly, all these mechanisms are involved in neurodegeneration. Although polyphenols display differences in their effectiveness due to interindividual variability, recent studies indicated that bioactive polyphenols in food and beverages promote health and prevent age-related cognitive decline. Polyphenols have a poor bioavailability and their digestion by gut microbiota produces active metabolites. In fact, dietary bioactive polyphenols need to be modified by microbiota present in the intestine before being absorbed, and to exert health preventive effects by interacting with cellular signalling pathways. This literature review includes an evaluation of the literature in English up to December 2019 in PubMed and Web of Science databases. A total of 307 studies, consisting of research reports, review articles and articles were examined and 146 were included. The review highlights the role of bioactive polyphenols in neurodegeneration, with a particular emphasis on the cellular and molecular mechanisms that are modulated by polyphenols involved in protection from oxidative stress and apoptosis prevention.

show abstract

“…Other study showed that quercetin glycoside (rutin, isoquercitrin) was capable of antagonising the changes in the gene expression induced by 6-hydroxydopamine in PC12 cells [5]. Protection of neuronal cells from Beta amyloid toxicity has been also reported [6]. The antioxidant capacity of QR has been ascribed to the presence of two pharmacophores within the molecule that have the optimal configuration for free radical scavenging, that is, the catechol group in the B ring and the OH group at position 3 [7].…”

Section: Introductionmentioning

confidence: 94%

Neuroprotective effect of quercetin in murine cortical brain tissue cultures

Haq

Alamro

2019

Clinical Nutrition Experimental

View full text Add to dashboard Cite

Purpose: Quercetin (QR) is bioflavonoids known for its antioxidants property and its ability to alleviate oxidative stress and promote cellular survival. The aim of this study was to explore the neuroprotective potential of QR against the induced oxidative stress. Methods: Cortical brain tissue cultures from one week old Wister rats were set up in four groups. Group 1: the control group without any treatments; Group 2: cortical cultures treated with 1 mM H 2 O 2 for one hour; Group 3: Cortical cultures pretreated with varying doses of QR for 24 h followed by treatment with 1 mM H 2 O 2 for 1 h; Group 4: Cortical cultures treated with the vehicle alone (DMSO). The cortical Tissues from all four groups were homogenized, both the homogenized cortical tissues and conditioned medium was used for the biochemical assay. For histology studies cortical brain tissue were fixed in 10% formalin and stained with H&E. Results: Pretreatment with 100 mg/ml showed the optimum concentration, which completely ameliorates the effect of induced oxidative stress by H 2 O 2. All of the biochemical markers of oxidative stress such as lipid peroxidation, GST enzyme assay, DNA damage and fragmentation were completely reversed with the pretreatments of QR. Histology of the cortical tissues further confirmed the biochemical assays as it showed the pretreatments with QR resulted in the neuronal survival and viability. Conclusions: This study further reiterated the neuroprotective role of QR against oxidative stress-related neurodegenerative disorders.

show abstract

Quercetin stabilizes apolipoprotein E and reduces brain Aβ levels in amyloid model mice

Cited by 56 publications

References 78 publications

DietaryAdvancedGlycationEnd Products–InducedCognitive Impairment in Aged ICR Mice: Protective Role of Quercetin

DietaryAdvancedGlycationEnd Products–InducedCognitive Impairment in Aged ICR Mice: Protective Role of Quercetin

Bioactive Polyphenols and Neuromodulation: Molecular Mechanisms in Neurodegeneration

Neuroprotective effect of quercetin in murine cortical brain tissue cultures

Contact Info

Product

Resources

About