Quercetin's effects on colon cancer cells apoptosis and proliferation in a rat model of disease

Tezerji, Sajjad; Robati, Fatemeh Nazari; abdolazimi, Hamid; Fallah, Azadeh; Talaei, Behrouz

doi:10.1016/j.clnesp.2022.01.004

Cited by 14 publications

(4 citation statements)

References 23 publications

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“…Compared to the control and healthy group, it was shown that the presence of quercetin (10 mg/kg of body weight) in the diet reduces cytological and morphological changes in the cells of healthy rats. This indicates the possibility of its use in the prevention and treatment of colon cancer [55].…”

Section: Anticancerogenic Properties Of S Nigra Lmentioning

confidence: 80%

“…Sambuci flos also contains quercetin, which, thanks to its ability to neutralize free radicals-mainly reactive oxygen species-and to bind to transition metal ions, has chemopreventive properties [50][51][52]. The analysis of the results of in vitro studies on cancer cell lines indicates the possible anticancer effect of quercetin in relation to various types of cancer, such as ovarian cancer, breast cancer, colorectal cancer and prostate cancer [53][54][55][56]. Khan et al indicate that among the phytochemicals, quercetin may be an alternative therapeutic option with limited side effects in the treatment of ovarian cancer.…”

Section: Anticancerogenic Properties Of S Nigra Lmentioning

confidence: 99%

See 1 more Smart Citation

Health-Promoting Properties: Anti-Inflammatory and Anticancer Properties of Sambucus nigra L. Flowers and Fruits

Stępień,

Trojniak,

Tabarkiewicz

2023

Molecules

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Sambucus nigra L. has been used for centuries in traditional medicine thanks to its valuable healing properties. The healing properties result from its high content of biologically active compounds, mainly antioxidants, which contribute to its anti-inflammatory and anticancer properties. In our review, we have presented scientific studies evaluating the anti-inflammatory and anticancer effects of extracts and their components from S. nigra L. flowers and fruits. The results of the research show that the effect of antioxidant phytochemicals contained in their composition reduces the level of free radicals and pro-inflammatory cytokines, prevents mutations that increase the risk of cancer development, and inhibits cell proliferation, induction of apoptosis, and changes in intracellular signaling, consequently inhibiting the growth of malignant tumors and the formation of metastases. Flowers and fruits of S. nigra L. are a valuable source of nutraceutical and pharmacological substances that can support prevention and anti-inflammatory and oncological therapy without negative side effects for the patient.

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Section: Anticancerogenic Properties Of S Nigra Lmentioning

confidence: 80%

Section: Anticancerogenic Properties Of S Nigra Lmentioning

confidence: 99%

Health-Promoting Properties: Anti-Inflammatory and Anticancer Properties of Sambucus nigra L. Flowers and Fruits

Stępień,

Trojniak,

Tabarkiewicz

2023

Molecules

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“…Our study showed that Que promoted the N-terminus release of GSDMD, accompanied by elevated levels of LDH, IL-1β, and IL-18 in vitro and in vivo. In colon cancer cells, the stimulation effect of Que on Cas3 has been reported [39]. Recently, several studies confirmed that C-Cas3 activation can switch apoptosis to pyroptosis in cells with GSDME expression [40,41].…”

Section: Discussionmentioning

confidence: 92%

Quercetin-induced pyroptosis in colon cancer through NEK7-mediated NLRP3 inflammasome-GSDMD signaling pathway activation

Feng

2024

Am J Cancer Res

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Pyroptosis, a gasdermin-mediated lytic cell death, is a new hotspot topic in cancer research, and induction of tumor pyroptosis has emerged as a new target in cancer management. Quercetin (Que), a natural substance, demonstrates promising anticancer action. However, further information is required to fully comprehend the function and mechanism of Que in pyroptosis in colon cancer. This study revealed the underlying mechanism of Queinduced pyroptosis in colon cancer in vitro and in vivo. Que inhibited colon cancer cell growth through gasdermin D (GSDMD)-mediated pyroptosis. Depletion of GSDMD, rather than gasdermin E (GSDME), reversed the cytotoxic effects of Que on colon cancer cells. Que treatment upregulated NIMA-related kinase 7 (NEK7) protein expression, thus facilitating the assembly of the NLRP3 inflammasome and cleavage of GSDMD. NEK7 silencing resulted in colon cancer cell growth in vitro and in vivo. Mechanistically, NEK7 depression restrained the activation of the NLRP3 inflammasome-GSDMD pathway, thus attenuating pyroptosis triggered by Que in colon cancer cells. Furthermore, lower NEK7 and NLRP3 expression levels indicated colon cancer progression. Our results unveiled a novel pattern of anti-colon cancer activity of Que, and activation of NEK7-mediated pyroptosis is potentially a promising therapeutic target for colon cancer, which provides novel experimental proof for the clinical application of Que.

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“…Studies conducted using rat models indicate the effect of QUE on colorectal cancer. The authors indicate an increase in the expression of genes for pro-apoptotic proteins, including caspase-3, and a decrease in the expression of anti-apoptotic genes, including Bcl-2, after the use of QUE, thus indicating its influence through the regulation of the internal mitochondrial pathway [ 71 ]. Later studies conducted on the SW48 colorectal cancer line also showed induction of apoptosis in cells after the use of QUE [ 72 ].…”

Section: Apoptosismentioning

confidence: 99%

Selected Flavonols Targeting Cell Death Pathways in Cancer Therapy: The Latest Achievements in Research on Apoptosis, Autophagy, Necroptosis, Pyroptosis, Ferroptosis, and Cuproptosis

Wendlocha,

Kubina,

Krzykawski

et al. 2024

Nutrients

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The complex and multi-stage processes of carcinogenesis are accompanied by a number of phenomena related to the potential involvement of various chemopreventive factors, which include, among others, compounds of natural origin such as flavonols. The use of flavonols is not only promising but also a recognized strategy for cancer treatment. The chemopreventive impact of flavonols on cancer arises from their ability to act as antioxidants, impede proliferation, promote cell death, inhibit angiogenesis, and regulate the immune system through involvement in diverse forms of cellular death. So far, the molecular mechanisms underlying the regulation of apoptosis, autophagy, necroptosis, pyroptosis, ferroptosis, and cuproptosis occurring with the participation of flavonols have remained incompletely elucidated, and the results of the studies carried out so far are ambiguous. For this reason, one of the therapeutic goals is to initiate the death of altered cells through the use of quercetin, kaempferol, myricetin, isorhamnetin, galangin, fisetin, and morin. This article offers an extensive overview of recent research on these compounds, focusing particularly on their role in combating cancer and elucidating the molecular mechanisms governing apoptosis, autophagy, necroptosis, pyroptosis, ferroptosis, and cuproptosis. Assessment of the mechanisms underlying the anticancer effects of compounds in therapy targeting various types of cell death pathways may prove useful in developing new therapeutic regimens and counteracting resistance to previously used treatments.

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Quercetin's effects on colon cancer cells apoptosis and proliferation in a rat model of disease

Cited by 14 publications

References 23 publications

Health-Promoting Properties: Anti-Inflammatory and Anticancer Properties of Sambucus nigra L. Flowers and Fruits

Health-Promoting Properties: Anti-Inflammatory and Anticancer Properties of Sambucus nigra L. Flowers and Fruits

Quercetin-induced pyroptosis in colon cancer through NEK7-mediated NLRP3 inflammasome-GSDMD signaling pathway activation

Selected Flavonols Targeting Cell Death Pathways in Cancer Therapy: The Latest Achievements in Research on Apoptosis, Autophagy, Necroptosis, Pyroptosis, Ferroptosis, and Cuproptosis

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