Quercetin Reverses Rat Liver Preneoplastic Lesions Induced by Chemical Carcinogenesis

Abstract

Quercetin is a flavonoid widely studied as a chemopreventive agent in different types of cancer. Previously, we reported that quercetin has a chemopreventive effect on the liver-induced preneoplastic lesions in rats. Here, we evaluated if quercetin was able not only to prevent but also to reverse rat liver preneoplastic lesions. We used the modified resistant hepatocyte model (MRHM) to evaluate this possibility. Treatment with quercetin was used 15 days after the induction of preneoplastic lesions. We found that quercetin reverses the number of preneoplastic lesions and their areas. Our results showed that quercetin downregulates the expression of EGFR and modulates this signaling pathway in spite of the activated status of EGFR as detected by the upregulation of this receptor, with respect to that observed in control rats. Besides, quercetin affects the phosphorylation status of Src-1, STAT5, and Sp-1. The better status of the liver after the treatment with quercetin could also be confirmed by the recovery in the expression of IGF-1. In conclusion, we suggest that quercetin reversed preneoplastic lesions by EGFR modulation and the activation state of Src, STAT5, and Sp1, so as the basal IGF-1.

Systematic Elucidation of the Mechanism of Quercetin against Gastric Cancer via Network Pharmacology Approach

“…Taken together, AKT1, EGFR, SRC, IGF1R, PTK2, and KDR are crucial in the pathogenesis of GC. These targets may be the key points of the therapeutic action of quercetin in GC, although several experiments have proven that quercetin can inhibit the expression of AKT1 [ 76 ], EGFR [ 77 ], SRC [ 78 ], IGF1R [ 79 ], PTK2 [ 80 ], and KDR [ 81 ]. Thus, the exact mechanism of quercetin on GC based on molecular docking requires further validation in biological experiments.…”

Pentagalloyl Glucose- and Ethyl Gallate-Rich Extract from Maprang Seeds Induce Apoptosis in MCF-7 Breast Cancer Cells through Mitochondria-Mediated Pathway

“…e mitochondriadependent pathway of apoptosis was triggered by DNA damage or an increase of ROS. It has been widely reported that ROS plays a crucial role in triggering cell damage, cell cycle progression, and cell death [39,40]. In this study, we reported that MPSE treatment could affect intracellular ROS production and mitochondrial dysfunction in breast cancer cells.…”

Chemical and molecular characterization of metabolites from Flavobacterium sp.

“…Quercetin also protects against acute liver injury, hepatic fibrosis, and lung carcinogenesis [ 34 – 36 ]. Quercetin reverses preneoplastic lesions by epidermal growth factor receptor modulation [ 37 ]. It can be used as a protective agent against coronary diseases [ 38 ].…”

“…Quercetin has a selective toxic effect on HuH7 and HepG2 liver cancer cells and normal human epithelial cell lines. Hepatocellular carcinoma cells undergo apoptosis through intrinsic pathway due to arrested cells in S phase by quercetin [ 37 ]. Cytotoxicity of quercetin against leukemic cells and breast cancer cells, but not healthy cells was reported [ 41 ].…”