Quercetin reduces manic-like behavior and brain oxidative stress induced by paradoxical sleep deprivation in mice

Kanazawa, Luiz Kae Sales; Vecchia, Débora Dalla; Wendler, Etiéli Mara; Hocayen, Palloma de Almeida Soares; Lívero, Francislaine Aparecida dos Reis; Stipp, Maria Carolina; Barcaro, Inara M.R.; Acco, Alexandra; Andreatini, Roberto

doi:10.1016/j.freeradbiomed.2016.07.027

Cited by 46 publications

(25 citation statements)

References 62 publications

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“…Sleep-deprived animals did not display manic phenotype when they were pretreated with lithium or TMX or their combination [52]. Intraperitoneal administration of quercetin also prevented PSD-induced hyperlocomotion [53]. Interestingly, PSD-induced behavioral changes were reversed by a one-time administration of lithium about 1 h prior to behavioral testing without affecting baseline activity [48].…”

Section: Pkc Translocation and Activitymentioning

confidence: 99%

“…Quercetin is a flavanol that contains a polyphenolic structure that scavenges free radicals and hence, acts as an antioxidant, and it also exhibits pleiotropic nonspecific PKC inhibition [127]. Kanazawa et al [53] showed that the quercetin administration was able to reverse the increase in lipid peroxidation in PFC, hippocampus, and striatum in a mouse model of mania induced by PSD. Quercetin also blocked methylphenidate-induced hyperlocomotion and oxidative stress in PFC, hippocampus, and striatum of mice [51].…”

Section: Downstream Targets Of Pkcmentioning

confidence: 99%

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Role of Protein Kinase C in Bipolar Disorder: A Review of the Current Literature

et al. 2017

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Bipolar disorder (BD) is a major health problem. It causes significant morbidity and imposes a burden on the society. Available treatments help a substantial proportion of patients but are not beneficial for an estimated 40-50%. Thus, there is a great need to further our understanding the pathophysiology of BD to identify new therapeutic avenues. The preponderance of evidence pointed towards a role of protein kinase C (PKC) in BD. We reviewed the literature pertinent to the role of PKC in BD. We present recent advances from preclinical and clinical studies that further support the role of PKC. Moreover, we discuss the role of PKC on synaptogenesis and neuroplasticity in the context of BD. The recent development of animal models of BD, such as stimulant-treated and paradoxical sleep deprivation, and the ability to intervene pharmacologically provide further insights into the involvement of PKC in BD. In addition, the effect of PKC inhibitors, such as tamoxifen, in the resolution of manic symptoms in patients with BD further points in that direction. Furthermore, a wide variety of growth factors influence neurotransmission through several molecular pathways that involve downstream effects of PKC. Our current understanding identifies the PKC pathway as a potential therapeutic avenue for BD.

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Section: Pkc Translocation and Activitymentioning

confidence: 99%

Section: Downstream Targets Of Pkcmentioning

confidence: 99%

Role of Protein Kinase C in Bipolar Disorder: A Review of the Current Literature

et al. 2017

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“…Our study demonstrated that RMFA exhibits AR inhibitory effects. Recently, quercetin reduces manic-like behavior and brain oxidative stress (Kanazawa et al 2016). Also it affects glutathione levels and redox in human aortic endothelial cells (Li et al 2016).…”

Section: Resultsmentioning

confidence: 99%

Aldose reductase inhibitory activity of quercetin from the stems ofRhododendron mucronulatumfor.albiflorum

Lee

Ryu

Rodriguez

et al. 2017

JABC

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The methanol extract of Rhododendron mucronulatum for. albiflorum (RMFA) stems inhibited aldose reductase (AR) activity. The RMFA fractions obtained by stepwise extraction with solvents of different polarity were tested for AR inhibition in vitro using the lens of a rat. Among them, the ethyl acetate (EtOAc) fraction inhibited AR more than the other fractions. Quercetin (1) from the EtOAc fraction showed a high AR inhibition with IC 50 of 2.11 μM. The stems of RMFA contained the highest amount (5.12 mg/g extract) of quercetin. Our results suggest that RMFA, which contained quercetin, could be a useful material for the development of supplementary functional foods.

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“…The simultaneous decrease in nNOS expression in whole brain homogenate at the protein and mRNA level probably further contributes to the phenomenon by removing neuroprotective basal NO formation. Interestingly, sleep deprivation has also been shown to impair the cerebral redox balance and to cause increased cerebral oxidative stress and abnormal (manic-like) behaviour and memory impairment, 58–60 conditions that are triggered by increased activity of the hypothalamic–pituitary–adrenal (HPA) axis, sympathetic activation and subsequent stress hormone production. In addition, Nox2 (gp91phox)-mediated increased oxidative stress was demonstrated to play an important role for learning and memory impairment.…”

Section: Discussionmentioning

confidence: 99%

Crucial role for Nox2 and sleep deprivation in aircraft noise-induced vascular and cerebral oxidative stress, inflammation, and gene regulation

Kröller‐Schön

Daiber

Steven

et al. 2018

European Heart Journal

156

186

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AimsAircraft noise causes endothelial dysfunction, oxidative stress, and inflammation. Transportation noise increases the incidence of coronary artery disease, hypertension, and stroke. The underlying mechanisms are not well understood. Herein, we investigated effects of phagocyte-type NADPH oxidase (Nox2) knockout and different noise protocols (around-the-clock, sleep/awake phase noise) on vascular and cerebral complications in mice.Methods and resultsC57BL/6j and Nox2−/− (gp91phox−/−) mice were exposed to aircraft noise (maximum sound level of 85 dB(A), average sound pressure level of 72 dB(A)) around-the-clock or during sleep/awake phases for 1, 2, and 4 days. Adverse effects of around-the-clock noise on the vasculature and brain were mostly prevented by Nox2 deficiency. Around-the-clock aircraft noise of the mice caused the most pronounced vascular effects and dysregulation of Foxo3/circadian clock as revealed by next generation sequencing (NGS), suggesting impaired sleep quality in exposed mice. Accordingly, sleep but not awake phase noise caused increased blood pressure, endothelial dysfunction, increased markers of vascular/systemic oxidative stress, and inflammation. Noise also caused cerebral oxidative stress and inflammation, endothelial and neuronal nitric oxide synthase (e/nNOS) uncoupling, nNOS mRNA and protein down-regulation, and Nox2 activation. NGS revealed similarities in adverse gene regulation between around-the-clock and sleep phase noise. In patients with established coronary artery disease, night-time aircraft noise increased oxidative stress, and inflammation biomarkers in serum.ConclusionAircraft noise increases vascular and cerebral oxidative stress via Nox2. Sleep deprivation and/or fragmentation caused by noise triggers vascular dysfunction. Thus, preventive measures that reduce night-time aircraft noise are warranted.

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Quercetin reduces manic-like behavior and brain oxidative stress induced by paradoxical sleep deprivation in mice

Cited by 46 publications

References 62 publications

Role of Protein Kinase C in Bipolar Disorder: A Review of the Current Literature

Role of Protein Kinase C in Bipolar Disorder: A Review of the Current Literature

Aldose reductase inhibitory activity of quercetin from the stems ofRhododendron mucronulatumfor.albiflorum

Crucial role for Nox2 and sleep deprivation in aircraft noise-induced vascular and cerebral oxidative stress, inflammation, and gene regulation

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