Quercetin reduces eIF2α phosphorylation by GADD34 induction

Hayakawa, Miki; Itoh, Masanori; Ohta, Kazunori; Li, Shimo; Ueda, Masashi; Wang, Miao-xing; Nishida, Emika; Islam, Saiful; Suzuki, Chihiro; Ohzawa, Kaori; Kobori, Masuko; Ishii, Takashi; Nakagawa, Toshiyuki

doi:10.1016/j.neurobiolaging.2015.05.006

Cited by 48 publications

(36 citation statements)

References 50 publications

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“…A Freeze-Frame system (Coulbourn Instruments; Whitehall, PA) and Actimetrics Freeze-Frame software (Coulbourn Instruments) were used for contextual and fear conditioning, as described previously [23]. Briefly, mice (n=7, three female and four male mice per group) were habituated for 15 minutes per day for 3 days.…”

Section: Behavioral Proceduresmentioning

confidence: 99%

“…Western blot was performed as described previously [23]. Mouse brain tissues (hippocampus, amygdala, cerebral cortex) were frozen by dry ice and homogenized in buffer A (10 mM Tris-HCl pH 7.5, 150 mM NaCl, 1 mM ethylenediaminetetraacetic acid, and 1% Nonidet P-40) containing protease and phosphatase inhibitors.…”

Section: Western Blotmentioning

confidence: 99%

“…Body weights and blood glucose levels of double-transgenic APP;db/db mice were significantly increased relative to those of APP mice (Figure 1a). Because ATF4 expression is significantly increased in the brains of APP;db/db mice relative to APP mice at 4-6 months of age [23], we examined the effects of ATF4 on memory impairment in early-stage AD model mice 8-11 months of age. We used two well-established memory tasks, namely, fear conditioning and NOR.…”

Section: Nor Memory Is Impaired In Early-stage App23 Mice With Obesitmentioning

confidence: 99%

“…Currently, it is unknown whether ATF4 is involved in obesityinduced memory impairment; however, ATF4 expression is increased in the brains of an aged APP23 AD mouse model [23] and AD patients [24]. Moreover, phosphorylated PERK is observed in AD patient neurons [25].…”

Section: Introductionmentioning

confidence: 99%

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Dietary Quercetin Ameliorates Memory Impairment in a Murine Model of Alzheimer’s Disease with Obesity and Diabetes, Suppressing ATF4 Expression

Nakagawa¹,

Ueda²,

Itoh³

et al. 2017

J Neurol Neurosci

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Background: While type 2 diabetes is a known risk factor for Alzheimer's disease (AD), the underlying mechanism of this relationship remains unclear. In a previous study, we demonstrated that brain expression of activating transcription factor 4 (ATF4) is increased in aged (12-month-old) amyloid-β precursor protein (APP) 23 mice (APP) and in the young (3-month-old) offspring of APP mice crossed with obese and diabetic db/db mice (APP;db/db). On this premise, we examined the relationship between ATF4 expression and memory in APP;db/db mice.

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Section: Behavioral Proceduresmentioning

confidence: 99%

Section: Western Blotmentioning

confidence: 99%

Section: Nor Memory Is Impaired In Early-stage App23 Mice With Obesitmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dietary Quercetin Ameliorates Memory Impairment in a Murine Model of Alzheimer’s Disease with Obesity and Diabetes, Suppressing ATF4 Expression

Nakagawa¹,

Ueda²,

Itoh³

et al. 2017

J Neurol Neurosci

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“…Quercetin also displays antiamyloidogenic properties, illustrated by its ability to reduce BACE1 and Aβ levels in mice (217), prevent Aβ aggregation (221,222), promote autophagy (221,223) and bind to BACE1 catalytic core as an inhibitor (224). On the other hand, quercetin enhances the effect of neurotrophic factors such as NGF (225) and BDNF (226) to foster neuronal survival and neurite outgrowth, with tangible amelioration of memory function in animal models of AD (227)(228)(229)(230)(231) and in In parallel, XBP1 can be locally synthetized within dendrites through SPRCs and transported into the nucleus to activate transcription of BDNF, Kalirin-7 and a myriad of other genes that are crucial for the survival and plasticity of neurons. mBDNF is released at synapses and activates TrkB receptors to recruit XBP1 and Kalirin-7, which controls spinogenesis through Rho-GTPases RAC1 and PAK1, resulting in a positive activation loop.…”

Section: Potential Mediators Of Xbp1 Signaling In Neuronsmentioning

confidence: 99%

The Transcription Factor XBP1 in Memory and Cognition: implications in Alzheimer’s Disease

Cissé

Duplan

Checler

2016

Mol Med

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X-box binding protein 1 (XBP1) is a unique basic region leucine zipper transcription factor that was isolated two decades ago in a search for regulators of major histocompatibility complex class II gene expression. XBP1 is a very complex protein that regulates many physiological functions, including the immune system, inflammatory responses and lipid metabolism. Evidence over the past few years suggests that XBP1 also plays an important role in pathological settings, since its activity as a transcription factor has profound effects on the prognosis and progression of diseases such as cancer, neurodegeneration and diabetes. Here we provide an overview of recent advances in our understanding of this multifaceted molecule, particularly in regulating synaptic plasticity and memory function, and the implications in neurodegenerative diseases, with an emphasis on Alzheimer's disease.

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Quercetin and its role in modulating endoplasmic reticulum stress: A review

Eisvand

Tajbakhsh

Seidel

et al. 2021

Phytotherapy Research

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The endoplasmic reticulum (ER) is the place where proteins and lipids are biosynthesized and where transmembrane proteins are folded. Both pathological and physiological situations may disturb the function of the ER, resulting in ER stress.Under stress conditions, the cells initiate a defensive procedure known as the unfolded protein response (UPR). Cases of severe stress lead to autophagy and/or the induction of cell apoptosis. Many studies implicate ER stress as a major factor contributing to many diseases. Therefore, the modulation of ER stress pathways has become an attractive therapeutic target. Quercetin is a plant-derived metabolite belonging to the flavonoids class which presents a range of beneficial effects including anti-inflammatory, cardioprotective, anti-oxidant, anti-obesity, anti-carcinogenic, anti-atherosclerotic, anti-diabetic, anti-hypercholesterolemic, and anti-apoptotic activities. Quercetin also has anti-cancer activity, and can be used as an adjuvant to decrease resistance to cancer chemotherapy. Furthermore, the effect of quercetin can be increased with the help of nanotechnology. This review discusses the role of quercetin in the modulation of ER stress (and related diseases) and provides novel evidence for the beneficial use of quercetin in therapy.

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Quercetin reduces eIF2α phosphorylation by GADD34 induction

Cited by 48 publications

References 50 publications

Dietary Quercetin Ameliorates Memory Impairment in a Murine Model of Alzheimer’s Disease with Obesity and Diabetes, Suppressing ATF4 Expression

Dietary Quercetin Ameliorates Memory Impairment in a Murine Model of Alzheimer’s Disease with Obesity and Diabetes, Suppressing ATF4 Expression

The Transcription Factor XBP1 in Memory and Cognition: implications in Alzheimer’s Disease

Quercetin and its role in modulating endoplasmic reticulum stress: A review

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