Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways

Nuclear Factor–Erythroid-2–Related Factor 2 in Aging and Lung Fibrosis

“…125 Quercetin-mediated Nrf2 nuclear translocation through p38 and extracellular signal regulated kinase signaling and induction of cytoprotective genes protects human hepatocytes against ethanol-derived oxidative stress. 126 Exposure of NIH3T3 cells and human lung fibroblasts to quercetin induces the nuclear translocation of Nrf2, induces HO-1, and suppresses transforming growth factorbesimulated collagen synthesis. 127 In addition to dietary compounds that are known to activate Nrf2, several chemical activators are being developed or are currently in clinical practice.…”

Optimal dietary protein level improved growth, disease resistance, intestinal immune and physical barrier function of young grass carp (Ctenopharyngodon idella)

“…Zhou et al [16] showed that the disruption of intestinal epithelial cell was closely related to apoptosis and oxidative damage in rats. Studies revealed that the gene expression of TJs, apoptosis and antioxidant capacity could be regulated by myosin light chain kinase (MLCK) [17], c-Jun N-terminal protein kinase (JNK) [18] and NF-E2-related factor 2 (Nrf2) [19] in humans, respectively. However, no study has addressed the effects of dietary proteins on the intestinal physical barriers and its possible mechanism in fish.…”

Heat Shock Proteins in Chronic Lymphocytic Leukaemia

“…Although, several compounds are able to inhibit the activity of HSF-1 and therefore regulate HSPA1A, the associated toxicity with HSF-1 and HSPA1A inhibitors is too severe. Furthermore, the inhibition of HSF-1 appears to have a number of associated effects such as the up-regulation of Hsp32, which itself is antiapoptotic (Lin et al 2004;Yao et al 2007). The flavanoid quercetin and the benzylidene lactam KNK-437 have both been shown to inhibit HSPA1A and HSPB1 and sensitise cells to chemotherapeutic drugs or hyperthermia (Taba et al 2011;Sahin et al 2011;Zanini et al 2007).…”