Quercetin protects against Aspergillus fumigatus keratitis by reducing fungal load and inhibiting TLR-4 induced inflammatory response

Luan, Junjie; Zhu, Yunan; Lin, Jing; Zhang, Yingxue; Xu, Qiang; Zhan, Lu; Tian, Xue; Zhao, Guiqiu; Peng, Xudong

doi:10.1016/j.cyto.2023.156356

Cited by 3 publications

(2 citation statements)

References 43 publications

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“…Quercetin, a natural compound with potent biological activity, possesses remarkable anti-inflammatory, antioxidant, antiproliferative, anticancer, and antiviral effects. It has found applications in various diseases, including keratitis, Alzheimer's disease and breast cancer (Kaboli et al, 2023;Luan et al, 2023;Tang et al, 2023). Notably, quercetin's robust antitumor activity has garnered increasing attention.…”

Section: Discussionmentioning

confidence: 99%

Quercetin alleviates hyperoxia‐induced bronchopulmonary dysplasia by inhibiting ferroptosis through the MAPK/PTGS2 pathway: Insights from network pharmacology, molecular docking, and experimental evaluations

Deng,

Chen,

Xie

et al. 2024

Chem Biol Drug Des

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Quercetin, a bioactive natural compound renowned for its potent anti‐inflammatory, antioxidant, and antiviral properties, has exhibited therapeutic potential in various diseases. Given that bronchopulmonary dysplasia (BPD) development is closely linked to inflammation and oxidative stress, and quercetin, a robust antioxidant known to activate NRF2 and influence the ferroptosis pathway, offers promise for a wide range of age groups. Nonetheless, the specific role of quercetin in BPD remains largely unexplored. This study aims to uncover the target role of quercetin in BPD through a combination of network pharmacology, molecular docking, computer analyses, and experimental evaluations.

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Section: Discussionmentioning

confidence: 99%

Quercetin alleviates hyperoxia‐induced bronchopulmonary dysplasia by inhibiting ferroptosis through the MAPK/PTGS2 pathway: Insights from network pharmacology, molecular docking, and experimental evaluations

Deng,

Chen,

Xie

et al. 2024

Chem Biol Drug Des

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“…Toll-like receptors (TLRs) are transmembrane receptors. After the recognition of PAMPs, the TLRs activate nuclear factor kappa B (NF-κB) either through the myeloid differentiation factor 88 (MyD88)-dependent or MyD88-independent pathway, triggering the expression of TNF-α, IL-1β, IL-6, IL-8, INF-γ, IL-12, IL-18, and MIP-2; initiating the immune response; and recruiting immune cells, such as macrophages and neutrophils to site of infection [44][45][46]. Among them, TLR2 and TLR4 are found on corneal epithelial cells and have been shown to play a key role in filamentous fungal keratitis.…”

Section: Immune Mechanismsmentioning

confidence: 99%

Immune Mechanisms of Filamentous Fungal Keratitis

Mpakosi,

Kaliouli-Antonopoulou

2024

Cureus

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Filamentous fungal keratitis is a particularly serious eye infection that often results in ulceration, corneal perforation, and blindness. The cornea acts as a natural barrier against harmful agents due to the close connection of its epithelial cells. In addition, on its surface, there is a large number of substances with antiinflammatory and bactericidal properties, such as secretory IgA and mucin glycoproteins, and antimicrobial peptides (AMPs), such as human β-defensin 2 (HBD-2) and LL-37, which are especially increased in filamentous fungal keratitis.The interaction between pathogenic fungi and the host's immune mechanisms is a complex process: pathogen-associated molecular pattern (PAMP) molecules (chitin, β-glucan, and mannan) found in the fungal cell wall are recognized by pattern recognition receptors (PRRs) (toll-like receptors {TLRs}, C-type lectin receptors {CLRs}, nucleotide-binding oligomerization domain-like receptors {NLRs}, and scavenger receptors {SR}) found in host defense cells, triggering the secretion of various types of cytokines, such as interleukins (IL), tumor necrosis factors (TNFs), and chemokines, which recruit macrophages and neutrophils to migrate to the site of infection and activate inflammatory responses.In addition, the interaction of hyphae and corneal epithelial cells can activate cluster of differentiation (CD) 4+ T cells, CD8+ T cells, and B cells and induce secretion of T-helper (Th)-type cytokines 2 (IL-4 and IL-13) and IgG.

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Formononetin protects against Aspergillus fumigatus Keratitis: Targeting inflammation and fungal load

Feng,

Gu,

Lin

et al. 2024

International Immunopharmacology

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Quercetin protects against Aspergillus fumigatus keratitis by reducing fungal load and inhibiting TLR-4 induced inflammatory response

Cited by 3 publications

References 43 publications

Quercetin alleviates hyperoxia‐induced bronchopulmonary dysplasia by inhibiting ferroptosis through the MAPK/PTGS2 pathway: Insights from network pharmacology, molecular docking, and experimental evaluations

Quercetin alleviates hyperoxia‐induced bronchopulmonary dysplasia by inhibiting ferroptosis through the MAPK/PTGS2 pathway: Insights from network pharmacology, molecular docking, and experimental evaluations

Immune Mechanisms of Filamentous Fungal Keratitis

Formononetin protects against Aspergillus fumigatus Keratitis: Targeting inflammation and fungal load

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