Quercetin protects against acetaminophen-induced hepatorenal toxicity by reducing reactive oxygen and nitrogen species

Hepatoprotective Effect of Quercetin Pretreatment Against Paracetamol-Induced Liver Damage and Partial Hepatectomy in Rats

“…The results of that study were significant for AST, ALT, and alkaline phosphatase, showing that quercetin reversed paracetamol-induced damage. It is possible that the extended period of quercetin administration in the study by El-Shafey et al 24 may explain the broader hepatoprotection and higher number of significant parameters as compared to the present study.No significant alterations were detected in alkaline phosphatase levels when the groups were compared. Some authors describe an increase in this enzyme in cases of paracetamol-induced liver damage 12,22 .…”

“…The same was observed by David et al 23 in an experimental model with thioacetamide. A recent work by El-Shafey et al 24 , in which oral quercetin was given to rats (15 mg/kg/day) during 21 days prior to a toxic dose of paracetamol, focused on many of the parameters assessed by us in the present study. The results of that study were significant for AST, ALT, and alkaline phosphatase, showing that quercetin reversed paracetamol-induced damage.…”

Chrysin Protects Rat Kidney from Paracetamol-Induced Oxidative Stress, Inflammation, Apoptosis, and Autophagy: A Multi-Biomarker Approach

“…Therefore, PC induces a depletion of cellular GSH stores. Binding cellular proteins, the remaining portion of NAPQI begins lipid peroxidation and ultimately induces kidney damage [5,6]. Therefore, PC toxicity is determined by the amount of NAPQI produced and the inadequate GSH for PC detoxification [7].…”

Amelioration of Trichosanthes lobata in Paracetamol-Induced Hepatic Damage in Rats: A Biochemical and Histopathological Evaluation

“…Inhibition of these protective mechanisms results in enhanced sensitivity to free radical-induced cellular damage. Excessive production of free radicals may results in alterations in the biological activity of hepatic cellular macromolecules 27 . Pre-treatment with TLAQ and TLAL extracts at (200 and 400 mg/kg) restored CAT activity in paracetamol-induced hepatic damage and thus prevent accumulation of excessive free radicals.…”