Quercetin prevents bone loss in hindlimb suspension mice via stanniocalcin 1-mediated inhibition of osteoclastogenesis

Niu, Youguo; Yang, Yuanyuan; Xiao, Xuan; Sun, Yang; Zhou, Yumei; Zhang, Yuhan; Dong, Dong; Li, Chenrui; Wu, Xuesong; Li, Yuhua; Mei, Qibing

doi:10.1038/s41401-020-00509-z

Cited by 18 publications

(15 citation statements)

References 35 publications

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“…Approximately 4000 natural products are known within the flavonoid family [ 216 ]. Many studies have reported that dietary flavonoid intake is closely related to reducing the risk of osteoporosis [ 217 , 218 , 219 , 220 , 221 , 222 , 223 , 224 , 225 , 226 , 227 ]. In our previous review [ 19 ], important non-flavonoid polyphenols (resveratrol, curcumin) as well as flavonoid polyphenols (genistein, daidzein, icariin, epigallocatechin gallate), which play a crucial role in skeletal health and prevention of osteoporosis were characterized.…”

Section: Flavonoid Polyphenols and Osteoporosismentioning

confidence: 99%

Section: Flavonoid Polyphenols and Osteoporosismentioning

confidence: 99%

“…Quercetin (3,5,7,3′,4′-pentahydroxyflavone) is a major dietary flavonoid in onion, red leaf lettuce, asparagus, green pepper, tomatoes and other vegetables, fruits and tea, as glycosides [ 227 , 228 ]. It has attracted great attention because of its anti-oxidative, anti-carcinogenic, anti-inflammatory, antibacterial, antiviral, anti-obesity, lipid-reducing and bone-conserving features [ 225 , 227 ]. Taking into account its protective effects against age-related bone loss, the in vivo study by Tsuji et al [ 229 ] showed that dietary quercetin (2.5% for 4 weeks) can increase BMD and improve cortical and trabecular bone microstructure in OVX mice.…”

Section: Flavonoid Polyphenols and Osteoporosismentioning

confidence: 99%

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The Role of Macronutrients, Micronutrients and Flavonoid Polyphenols in the Prevention and Treatment of Osteoporosis

et al. 2022

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Osteoporosis is considered an age-related disorder of the skeletal system, characterized primarily by decreased bone mineral density (BMD), microstructural quality and an elevated risk of fragility fractures. This silent disease is increasingly becoming a global epidemic due to an aging population and longer life expectancy. It is known that nutrition and physical activity play an important role in skeletal health, both in achieving the highest BMD and in maintaining bone health. In this review, the role of macronutrients (proteins, lipids, carbohydrates), micronutrients (minerals—calcium, phosphorus, magnesium, as well as vitamins—D, C, K) and flavonoid polyphenols (quercetin, rutin, luteolin, kaempferol, naringin) which appear to be essential for the prevention and treatment of osteoporosis, are characterized. Moreover, the importance of various naturally available nutrients, whether in the diet or in food supplements, is emphasized. In addition to pharmacotherapy, the basis of osteoporosis prevention is a healthy diet rich mainly in fruits, vegetables, seafood and fish oil supplements, specific dairy products, containing a sufficient amount of all aforementioned nutritional substances along with regular physical activity. The effect of diet alone in this context may depend on an individual’s genotype, gene-diet interactions or the composition and function of the gut microbiota.

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Section: Flavonoid Polyphenols and Osteoporosismentioning

confidence: 99%

Section: Flavonoid Polyphenols and Osteoporosismentioning

confidence: 99%

Section: Flavonoid Polyphenols and Osteoporosismentioning

confidence: 99%

See 1 more Smart Citation

The Role of Macronutrients, Micronutrients and Flavonoid Polyphenols in the Prevention and Treatment of Osteoporosis

et al. 2022

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“…It has been shown that quercetin has a beneficial effect on bone resorption, osteogenic differentiation and overall bone repair mechanisms [19,20]. Some reports displayed that quercetin treatment enhanced the osteoblastogenic differentiation of pre-osteoblasts through increased ALP activity and mineralization [21].…”

Section: Discussionmentioning

confidence: 99%

Effect of Quercetin 3-O-β-D-Galactopyranoside on the Adipogenic and Osteoblastogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stromal Cells

Karadeniz

Seo

et al. 2020

IJMS

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Natural products, especially phenols, are promising therapeutic agents with beneficial effects against aging-related complications such as osteoporosis. This study aimed to investigate the effect of quercetin 3-O-β-D-galactopyranoside (Q3G), a glycoside of a common bioactive phytochemical quercetin, on osteogenic and adipogenic differentiation of human bone marrow-derived mesenchymal stromal cells (hBM-MSCs). hBM-MSCs were induced to differentiate into osteoblasts and adipocytes in the presence or absence of Q3G and the differentiation markers were analyzed to observe the effect. Q3G treatment stimulated the osteoblastogenesis markers: cell proliferation, alkaline phosphatase (ALP) activity and extracellular mineralization. In addition, it upregulated the expression of RUNX2 and osteocalcin protein as osteoblastogenesis regulating transcription factors. Moreover, Q3G treatment increased the activation of osteoblastogenesis-related Wnt and bone morphogenetic protein (BMP) signaling displayed as elevated levels of phosphorylated β-catenin and Smad1/5 in nuclear fractions of osteo-induced hBM-MSCs. The presence of quercetin in adipo-induced hBM-MSC culture inhibited the adipogenic differentiation depicted as suppressed lipid accumulation and expression of adipogenesis markers such as PPARγ, SREBP1c and C/EBPα. In conclusion, Q3G supplementation stimulated osteoblast differentiation and inhibited adipocyte differentiation in hBM-MSCs via Wnt/BMP and PPARγ pathways, respectively. This study provided useful information of the therapeutic potential of Q3G against osteoporosis mediated via regulation of MSC differentiation.

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“…Natural products are important and reliable resources for the prevention and treatment of osteoporosis because they have fewer side effects and are more suitable for long-term application compared with chemosynthetic medicines [9]. Ginseng, the root of Panax ginseng C.A.…”

Section: Introductionmentioning

confidence: 99%

Biochemical Targets and Molecular Mechanism of Ginsenoside Compound K for Treating Osteoporosis Based on Network Pharmacology

Zhang¹,

Shen²,

Ma³

et al. 2021

Preprint

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Ginsenosides have been proven to be potential beneficial in treatment of osteoporosis. To investigate the potential of ginsenosides in osteoporosis, ginsenoside compound K (GCK) was selected to explore the potential therapy targets and mechanism based on network pharmacology (NP). 206 and 6590 targets were obtained for GCK and osteoporosis, respectively, in which 138 targets were identified as co-targets of GCK and osteoporosis based on intersection analysis. Five central gene clusters and hub genes (STAT3, PIK3R1, VEGFA, JAK2 and MAP2K1) were identified through protein-protein interaction network analysis. Gene Ontology (GO) enrichment implied that phosphatidylinositol-related biological process, molecular modification and function may play an important role for GCK in treatment and prevention of osteoporosis. Functions and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis suggested that 16 targets were enriched in the osteoclast differentiation. Also, except for being identified as hub targets, MAPK and phosphatidylinositol-related proteins were enriched in the downstream signaling of c-Fms in the osteoclast differentiation pathway. Molecular docking further confirmed that GCK could interact with active cavity on the surface of c-Fms (osteoclast differentiation-related membrane receptor), and their complex could be stabilized by three H-bonds with residues including Glu 664 (3.19 Å), Glu 664 (2.62 Å) and Cys 666 (2.78 Å). Summarily, GCK could interfere the occurrence and progress of osteoporosis through c-Fms-mediated MAPK and phosphatidylinositol-related signaling regulating osteoclast differentiation.

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Quercetin prevents bone loss in hindlimb suspension mice via stanniocalcin 1-mediated inhibition of osteoclastogenesis

Cited by 18 publications

References 35 publications

The Role of Macronutrients, Micronutrients and Flavonoid Polyphenols in the Prevention and Treatment of Osteoporosis

The Role of Macronutrients, Micronutrients and Flavonoid Polyphenols in the Prevention and Treatment of Osteoporosis

Effect of Quercetin 3-O-β-D-Galactopyranoside on the Adipogenic and Osteoblastogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stromal Cells

Biochemical Targets and Molecular Mechanism of Ginsenoside Compound K for Treating Osteoporosis Based on Network Pharmacology

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