Quercetin Potentiates Doxorubicin Mediated Antitumor Effects against Liver Cancer through p53/Bcl-xl

Wang, Guanyu; Zhang, Jiawei; Liu, Luying; Sharma, Sherven; Dong, Qian

doi:10.1371/journal.pone.0051764

Cited by 108 publications

(91 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DOX-induced apoptosis is stimulated through two mechanisms: the death receptor pathway and the mitochondrial pathway [46]. The mitochondrial apoptotic pathway is regulated by various apoptosis-related genes, such as Bax [47].…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Artemisia judaica against Doxorubicin-Induced Toxicity in Mice

Ahmed

Mabrouk

Hassanane

et al. 2017

ARRB

View full text Add to dashboard Cite

Aim: The present study aimed to investigate the protective effect of Artemisia Judaica (A. Judaica) against doxorubicin (DOX)-induced toxicity in male mice. Place and Duration of Study: Department of Cell Biology, Genetic engineering and biotechnology division, National research centre, Egypt, between March 2016 and February 2017. Methodology: Male mice were divided into 7 groups (n=10) and treated as follow: the control group, the group treated with DMSO, the group injected (i.p.) with DOX , the groups treated with low and high dose of A. judaica extract and the groups injected (i.p.) with DOX and treated with low and high dose of A. judaica extract. Femur, testes and liver samples were collected for different analyses. Results: Our data showed that A. judaica significantly reversed the DOX-induced elevation of DNA fragmentation rate and MDA level in liver tissue, as well as declined chromosomal aberrations (CAs) either in the bone marrow cells or in the spermatocyte cells. Meanwhile, the expression of Ahmed et al.; ARRB, 18(3): 1-10, 2017; Article no.ARRB.35990 2 apoptosis-related genes (Bax and Caspase-3) in liver tissues was analyzed by quantitative real-time PCR (qRT-PCR) and results revealed that genes expression were up-regulated in DOX treated mice however; the administration of A. judaica didn't alter such increase. Conclusion: Overall, the findings indicated that A. judaica may attenuate the DOX-induced toxicity. However; further studies are required to confirm the protective effect of A. judaica extract against toxicity caused by DOX drug. Original Research Article

show abstract

Section: Discussionmentioning

confidence: 99%

Protective Effect of Artemisia judaica against Doxorubicin-Induced Toxicity in Mice

Ahmed

Mabrouk

Hassanane

et al. 2017

ARRB

View full text Add to dashboard Cite

show abstract

“…In cancer, besides the association of drugs commonly used in chemotherapy have also been investigated the combined effect of these drugs with natural compounds. So, there are already different studies in which is intended to clarify the therapeutic effect of quercetin in combination with several drugs used in the cancer treatment like doxorubicin [75,76], 5-fluorouracil [77][78][79], cisplatin [80][81][82][83], dacarbazin [84], etoposide [77], daunorubicin [85], temozolomide [85], camptothecin [77], gemcitabine [55,86], lapatinib [87], oxaliplatin [83], sorafenib [88], tamoxifen [89] and trichostatin A [90] (Table 1).…”

Section: Combination Therapymentioning

confidence: 99%

“…Emphasizing the potential that this kind of combined therapies has in the treatment of oncological diseases, studies of combination therapy with quercetin have been carried out in several types of cancers such as prostate cancer [77], colorectal cancer [78], hepatocellular carcinoma (HCC) [75,81], lung cancer [82,90], pancreatic carcinoma [53,85] and breast cancer [74,87,89] (Table 1).…”

Section: Combination Therapymentioning

confidence: 99%

Quercetin in Cancer Treatment, Alone or in Combination with Conventional Therapeutics?

Brito¹,

Ribeiro²,

Abrantes

et al. 2015

CMC

128

View full text Add to dashboard Cite

Abstract:Cancer is a problem of global importance, since the incidence is increasing worldwide and therapeutic options are generally limited. Thus, it becomes imperative to find new therapeutic targets as well as new molecules with therapeutic potential for tumors. Flavonoids are polyphenolic compounds that may be potential therapeutic agents. Several studies have shown that these compounds have a higher anticancer potential. Among the flavonoids in the human diet, quercetin is one of the most important. In the last decades, several anticancer properties of quercetin have been described, such as cell signaling, pro-apoptotic, anti-proliferative and anti-oxidant effects, growth suppression. In fact, it is now well known that quercetin has diverse biological effects, inhibiting multiple enzymes involved in cell proliferation, as well as, in signal transduction pathways. On the other hand, there are also studies reporting potential synergistic effects when combined quercetin with chemotherapeutic agents or radiotherapy. In fact, several studies which aim to explore the anticancer potential of these combined treatments have already been published, the majority with promising results. Actually it is well known that quercetin can act on the chemosensitization and radiosensitization but also as chemoprotective and radioprotective, protecting normal cells of the side effects that results from chemotherapy and radiotherapy, which obviously provides notable advantages in their use in anticancer treatment. Thus, all these data indicate that quercetin may have a key role in anticancer treatment. In this context, this review is focused on the relationship between flavonoids and cancer, with special emphasis on the role of quercetin.

show abstract

“…It is well known that flavonoids, quercetin in particular, are not just capable of inducing apoptosis as single agents at higher concentrations, but may also interact with known apoptosis inducers -various classes of cytotoxic chemotherapeutic agents -and potentia te their cytotoxic and proapoptotic effects. For exam ple, quercetin may potentiate cytotoxic effect of doxo rubicin in human hepatocarcinoma SMMC7721 cells and cisplatin in human ovary adenocarcinoma cells [19,20].…”

Section: Fig 3 Distribution Of Jurkat Cell Population Incubated Formentioning

confidence: 99%

Rhamnazin inhibits proliferation and induces apoptosis of human jurkat leukemia cells in vitro

Philchenkov¹,

Zavelevych²

2015

Ukr.Biochem.J.

View full text Add to dashboard Cite

Quercetin Potentiates Doxorubicin Mediated Antitumor Effects against Liver Cancer through p53/Bcl-xl

Cited by 108 publications

References 46 publications

Protective Effect of Artemisia judaica against Doxorubicin-Induced Toxicity in Mice

Protective Effect of Artemisia judaica against Doxorubicin-Induced Toxicity in Mice

Quercetin in Cancer Treatment, Alone or in Combination with Conventional Therapeutics?

Rhamnazin inhibits proliferation and induces apoptosis of human jurkat leukemia cells in vitro

Contact Info

Product

Resources

About