Quercetin mitigates scopolamine-induced memory dysfunction: impact on oxidative stress and cholinergic mechanisms

Olayinka, Juliet N; Eduviere, Anthony T.; Adeoluwa, Olusegun; Akinluyi, Elizabeth Toyin; Obisesan, Abiola O.; Akawa, Oluwole B.; Adebanjo, Adeshina Samuel

doi:10.1007/s11011-021-00861-x

Cited by 6 publications

(2 citation statements)

References 51 publications

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“…Further, studies have also reported the MAO‐B and COMT inhibitory potential of quercetin in the PD rat model (Larit et al, 2018; Singh et al, 2003). Similarly, in mouse and rat models of AD, quercetin is reported to show AChE and Aβ inhibitory potential, ameliorate oxidative stress and neuroinflammation, suppress tau hyperphosphorylation and improve memory and cognition and oxidative stress making it a favourable candidate for AD therapy (Álvarez‐Berbel et al, 2022; Molaei et al, 2020; Olayinka et al, 2022; Paula et al, 2019). However, quercetin is reported to possess low bioavailability and exert toxic effects at higher intake (Batiha et al, 2020; D'Andrea, 2015; Jain et al, 2013), while other studies reported that this molecule is well tolerated and exerts no toxicity (Cunningham et al, 2022).…”

Section: Phyto‐compounds and Their Neuroprotective Effects In Ad And ...mentioning

confidence: 99%

Therapeutic considerations of bioactive compounds in Alzheimer's disease and Parkinson's disease: Dissecting the molecular pathways

Phukan,

Roy,

Gahatraj

et al. 2023

Phytotherapy Research

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Leading neurodegenerative diseases Alzheimer's disease (AD) and Parkinson's disease (PD) are characterized by the impairment of memory and motor functions, respectively. Despite several breakthroughs, there exists a lack of disease‐modifying treatment strategies for these diseases, as the available drugs provide symptomatic relief and bring along side effects. Bioactive compounds are reported to bear neuroprotective properties with minimal toxicity, however, a detailed elucidation of their modes of neuroprotection is lacking. The review elucidates the neuroprotective mechanism(s) of some of the major phyto‐compounds in pre‐clinical and clinical studies of AD and PD to understand their potential in combating these diseases. Curcumin, eugenol, resveratrol, baicalein, sesamol and so on have proved efficient in countering the pathological hallmarks of AD and PD. Curcumin, resveratrol, caffeine and so on have reached the clinical phases of these diseases, while aromadendrin, delphinidin, cyanidin and xanthohumol are yet to be extensively explored in pre‐clinical phases. The review highlights the need for extensive investigation of these compounds in the clinical stages of these diseases so as to utilize their disease‐modifying abilities in the real field of treatment. Moreover, poor pharmacokinetic properties of natural compounds are constraints to their therapeutic yields and this review suggests a plausible contribution of nanotechnology in overcoming these limitations.

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Section: Phyto‐compounds and Their Neuroprotective Effects In Ad And ...mentioning

confidence: 99%

Therapeutic considerations of bioactive compounds in Alzheimer's disease and Parkinson's disease: Dissecting the molecular pathways

Phukan,

Roy,

Gahatraj

et al. 2023

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…Scopolamine administration causes short-term and long-term memory loss because it blocks muscarinic cholinergic receptors in the brain and interferes with learning and memory [94,95]. There are studies that have found that Que alleviates scopolamine-induced memory deficits by protecting against neuroinflammation and neurodegeneration by inhibiting OS and acetylcholinesterase activity, reverses synaptic loss in the cortex and hippocampus of the brain of adult mice, and suppresses memory impairment [94,95].…”

Section: Alzheimer's Diseasementioning

confidence: 99%

Exploitation of Quercetin’s Antioxidative Properties in Potential Alternative Therapeutic Options for Neurodegenerative Diseases

et al. 2023

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Oxidative stress (OS) is a condition in which there is an excess of reactive oxygen species (ROS) in the body, which can lead to cell and tissue damage. This occurs when there is an overproduction of ROS or when the body’s antioxidant defense systems are overwhelmed. Quercetin (Que) is part of a group of compounds called flavonoids. It is found in high concentrations in vegetables, fruits, and other foods. Over the past decade, a growing number of studies have highlighted the therapeutic potential of flavonoids to modulate neuronal function and prevent age-related neurodegeneration. Therefore, Que has been shown to have antioxidant, anticancer, and anti-inflammatory properties, both in vitro and in vivo. Due to its antioxidant character, Que alleviates oxidative stress, thus improving cognitive function, reducing the risk of neurodegenerative diseases. On the other hand, Que can also help support the body’s natural antioxidant defense systems, thus being a potentially practical supplement for managing OS. This review focuses on experimental studies supporting the neuroprotective effects of Que in Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and epilepsy.

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Vitamin B1 via Nrf-2/TLR4 signaling pathway ameliorates scopolamine-induced memory dysfunction in adult mice

Nasir,

Khan,

Noreen

et al. 2024

Arabian Journal of Chemistry

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Quercetin mitigates scopolamine-induced memory dysfunction: impact on oxidative stress and cholinergic mechanisms

Cited by 6 publications

References 51 publications

Therapeutic considerations of bioactive compounds in Alzheimer's disease and Parkinson's disease: Dissecting the molecular pathways

Therapeutic considerations of bioactive compounds in Alzheimer's disease and Parkinson's disease: Dissecting the molecular pathways

Exploitation of Quercetin’s Antioxidative Properties in Potential Alternative Therapeutic Options for Neurodegenerative Diseases

Vitamin B1 via Nrf-2/TLR4 signaling pathway ameliorates scopolamine-induced memory dysfunction in adult mice

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