Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43

Pietsch, Kerstin; Saul, Nadine; Menzel, Ralph; Stürzenbaum, Stephen R.; Steinberg, Christian E. W.

doi:10.1007/s10522-008-9199-6

Cited by 140 publications

(157 citation statements)

References 70 publications

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“…This is not surprising considering that individual components in the OSR-1/UNC-43/SEK-1 pathway have been reported to differentially mediate the prolongevity effects of different phytochemicals. For instance, SEK-1, but neither OSR-1 nor UNC-43, is required for tannic acid-induced longevity (Saul et al 2010), while SEK-1 and UNC-43, but not OSR-1, are required for quercetin-induced longevity in C. elegans (Pietsch et al 2009). In addition, SEK-1 can regulate pathogen resistance independent of UNC-43 and OSR-1 (Kim et al 2002).…”

Section: Discussionmentioning

confidence: 99%

“…The heat shock assay was performed as described previously (Pietsch et al 2009;Strayer et al 2003) with some modifications. CBE-pretreated L4/young adult stage worms and controls were transferred to CBE supplemented (2 mg/mL) plates and regular NGM plates, respectively.…”

Section: Stress Assaysmentioning

confidence: 99%

“…5a; Table 1). Since osr-1(rm1) worms are short-lived (Pietsch et al 2009;Saul et al 2010), it is possible that osr-1(rm1) mutant worms are sick in general, which may mask any apparent longevity benefit of CBE supplementation. To address this issue, we assessed several general health parameters in osr-1 (rm1) worms, including body size, motility, and touch Fig.…”

Section: Cbe Supplementation Modulates Lifespan Through the Iis Pathwmentioning

confidence: 99%

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The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1

Guha

Cao

Kane

et al. 2012

AGE

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Nutraceuticals are known to have numerous health and disease preventing properties. Recent studies suggest that extracts containing cranberry may have anti-aging benefits. However, little is known about whether and how cranberry by itself promotes longevity and healthspan in any organism. Here we examined the effect of a cranberry only extract on lifespan and healthspan in Caenorhabditis elegans. Supplementation of the diet with cranberry extract (CBE) increased the lifespan in C. elegans in a concentration-dependent manner. Cranberry also increased tolerance of C. elegans to heat shock, but not to oxidative stress or ultraviolet irradiation. In addition, we tested the effect of cranberry on brood size and motility and found that cranberry did not influence these behaviors. Our mechanistic studies indicated that lifespan extension induced by CBE requires the insulin/IGF signaling pathway and DAF-16. We also found that cranberry promotes longevity through osmotic stress resistant-1 (OSR-1) and one of its downstream effectors, UNC-43, but not through SEK-1, a component of the p38 MAP kinase pathway. However, SIR-2.1 and JNK signaling pathways are not required for cranberry to promote longevity. Our findings suggest that cranberry supplementation confers increased longevity and stress resistance in C. elegans through pathways modulated by daf-16 and osr-1. This study reveals the anti-aging property of widely consumed cranberry and elucidates the underpinning mechanisms.

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Section: Discussionmentioning

confidence: 99%

Section: Stress Assaysmentioning

confidence: 99%

Section: Cbe Supplementation Modulates Lifespan Through the Iis Pathwmentioning

confidence: 99%

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The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1

Guha

Cao

Kane

et al. 2012

AGE

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“…Of the nine studies on quercetin, seven reported quercetin as prolonging lifespan at concentrations ranging from approximately 70 to 200 µM (35)(36)(37)(38)(39)(40)(41) . One study supplementing quercetin at 166 µM could not detect lifespan extension (42) , another study applying quercetin at 50 and 250 µM reported no change and a decrease in lifespan, respectively (43) .…”

Section: Flavonoids and The Lifespan Of The Worm Caenorhabditis Elegansmentioning

confidence: 99%

“…However, in an age-1 mutant (phosphoinositide-3-kinase subunit p110 homologue) catechin increased lifespan, while quercetin did not. In turn, catechin failed to increase lifespan in an akt-2 (AKT homologue) mutant, while quercetin could K. Pallauf et al 158 prolong lifespan in these worms (30,37) . In contrast to quercetin and catechin, the life-expanding impact of icariside II, myricetin, cocoa powder and purple wheat extract was abolished by mutating daf-16, the worm FOXO homologue (45,46) .…”

Section: Studies In Mutantsmentioning

confidence: 99%

A literature review of flavonoids and lifespan in model organisms

Pallauf¹,

Duckstein²,

Rimbach³

2016

Proc. Nutr. Soc.

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Epidemiological data on consumption of flavonoid-containing food points to the notion that some of these secondary plant metabolites may favour healthy ageing. The aim of the present paper was to review the literature on lifespan extension by flavonoids in worms, flies and mice. In most studies, worms and flies experienced lifespan extension when supplemented with flavonoids either as extracts or single compounds. Studies with mutant worms and flies give hints as to which gene products may be regulated by flavonoids and consequently enhance longevity. We discuss the data considering putative mechanisms that may underlie flavonoid action such as energy-restriction-like effects, inhibition of insulin-like-growth-factor signalling, induction of antioxidant defence mechanisms, hormesis as well as antimicrobial properties. However, it remains uncertain whether human lifespan could be prolonged by increased flavonoid intake.

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Curcumin and neurodegenerative diseases

2013

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Over the last ten years curcumin has been reported to be effective against a wide variety of diseases and is characterized as having anti-carcinogenic, hepatoprotective, thrombosuppressive, cardioprotective, anti-arthritic, and anti-infectious properties. Recent studies performed in both vertebrate and invertebrate models have been conducted to determine whether curcumin was also neuroprotective. The efficacy of curcumin in several pre-clinical trials for neurodegenerative diseases has created considerable excitement mainly due to its lack of toxicity and low cost. This suggests that curcumin could be a worthy candidate for nutraceutical intervention. Since aging is a common risk factor for neurodegenerative diseases, it is possible that some compounds that target aging mechanisms could also prevent these kinds of diseases. One potential mechanism to explain several of the general health benefits associated with curcumin is that it may prevent aging-associated changes in cellular proteins that lead to protein insolubility and aggregation. This loss in protein homeostasis is associated with several age-related diseases. Recently, curcumin has been found to help maintain protein homeostasis and extend lifespan in the model invertebrate Caenorhabditis elegans. Here, we review the evidence from several animal models that curcumin improves healthspan by preventing or delaying the onset of various neurodegenerative diseases.

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Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43

Cited by 140 publications

References 70 publications

The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1

The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1

A literature review of flavonoids and lifespan in model organisms

Curcumin and neurodegenerative diseases

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