Quercetin-Loaded Lecithin/Chitosan Nanoparticles for Functional Food Applications

Souza, Marthyna Pessoa de; Vaz, Antônio Fernando de Melo; Correia, Maria T.S.; Cerqueira, Miguel A.; Carneiro-da-Cunha, Maria G.

doi:10.1007/s11947-013-1160-2

Cited by 145 publications

(69 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We considered that high concentrations of KAE occur to decrease the spacing between nanoparticles and lead to the blockage of the repulsive interaction between the nanoparticles and aggregation. The results are in agreement with the previous studies (Barbieri et al 2013, Pool et al 2012, Souza et al 2014). Based on the results, the formulation of KAE-LC NPs nanoparticles prepared 40 lg/mL KAE concentration was further evaluated.…”

Section: Resultssupporting

confidence: 94%

“…Furthermore, in the nanoparticle spectrum, the presence of an absorption band at 1230 cm À1 corresponding to P¼O stretching was indicative that ionic interactions between phosphate groups of lipids (lecithin) and amino groups of polysaccharides (chitosan) occurred. From the FTIR spectrum of KAE-LC NPs observed that encapsulation of KAE in the KAE-LC NPs was formed by what appears to be that appear by hydrophobic interactions (Souza et al 2014, Zhang et al 2008). The formation of hydrogen bonding can be also evaluated by the change in chemical shifts in NMR spectra.…”

Section: Intermolecular Interactions Between Kae and Kae-lc Npsmentioning

confidence: 99%

See 1 more Smart Citation

Kaempferol loaded lecithin/chitosan nanoparticles: preparation, characterization, and their potential applications as a sustainable antifungal agent

Torun

Saglam

Özgen

2016

Artificial Cells, Nanomedicine, and Biotechnology

View full text Add to dashboard Cite

Flavonoid compounds are strong antioxidant and antifungal agents but their applications are limited due to their poor dissolution and bioavailability. The use of nanotechnology in agriculture has received increasing attention, with the development of new formulations containing active compounds. In this study, kaempferol (KAE) was loaded into lecithin/chitosan nanoparticles (LC NPs) to determine antifungal activity compared to pure KAE against the phytopathogenic fungus Fusarium oxysporium to resolve the bioavailability problem. The influence of formulation parameters on the physicochemical properties of KAE loaded lecithin chitosan nanoparticles (KAE-LC NPs) were studied by using the electrostatic self-assembly technique. KAE-LC NPs were characterized in terms of physicochemical properties. KAE has been successfully encapsulated in LC NPs with an efficiency of 93.8 ± 4.28% and KAE-LC NPs showed good physicochemical stability. Moreover, in vitro evaluation of the KAE-LC NP system was made by the release kinetics, antioxidant and antifungal activity in a time-dependent manner against free KAE. Encapsulated KAE exhibited a significantly inhibition efficacy (67%) against Fusarium oxysporium at the end of the 60 day storage period. The results indicated that KAE-LC NP formulation could solve the problems related to the solubility and loss of KAE during use and storage. The new nanoparticle system enables the use of smaller quantities of fungicide and therefore, offers a more environmentally friendly method of controlling fungal pathogens in agriculture.

show abstract

Section: Resultssupporting

confidence: 94%

Section: Intermolecular Interactions Between Kae and Kae-lc Npsmentioning

confidence: 99%

Kaempferol loaded lecithin/chitosan nanoparticles: preparation, characterization, and their potential applications as a sustainable antifungal agent

Torun

Saglam

Özgen

2016

Artificial Cells, Nanomedicine, and Biotechnology

View full text Add to dashboard Cite

show abstract

“…Besides, the absorption band at 1612, 1562, 1523, 1450 cm −1 of quercetin can be assigned to CC aromatic double bond stretching. The spectrum for pure quercetin was consistent with the previous studies . The IR absorption peaks of quercetin were almost as clear as that of the pure quercetin in the physical mixture, which disappeared in the encapsulating formula.…”

Section: Resultssupporting

confidence: 89%

Enhanced oral bioavailability of quercetin by a new non‐aqueous self‐double‐emulsifying drug delivery system

Wang

Qian

et al. 2016

Euro J Lipid Sci & Tech

View full text Add to dashboard Cite

The present study investigated a new non‐aqueous self‐double‐emulsifying drug delivery system (SDEDDS) to enhance oral bioavailability of quercetin (QT), a drug with poor water solubility. The new formulation was prepared using a modified two‐step method and evaluated in vitro and in vivo. The optimized formulation consisted of oil‐in‐oil emulsions and hydrophilic surfactant that could spontaneously emulsify to oil‐in‐oil‐in‐water (O/O/W) double emulsions in the mixed aqueous gastrointestinal environment, with drugs mainly encapsulated in the inner oil phase of the double emulsions. Furthermore, the non‐aqueous QT‐SDEDDS exhibited sustained release of quercetin under conditions mimicking gastrointestinal tract, and gave significantly higher AUC and Cmax than did quercetin control suspension (p < 0.05). In particular, the AUC of the non‐aqueous QT‐SEDDS was about 5.22‐fold higher than that of drug control suspension, with an absolute bioavailability of 26.67%. The obtained results demonstrated that SDEDDS was successfully developed and could be a promising technique for improving the oral bioavailability of quercetin with low solubility. Practical applications: Conventional SDEDDS is mainly designed to encapsulate, protect, and release hydrophilic bioactive components. Hence, the new non‐aqueous SDEDDS could as a drug delivery system to encapsulate hydrophobic drug with low oral bioavailability. Pharmacokinetic studies have displayed increased relative bioavailability (more than fivefold) of QT‐SDEDDS compared to quercetin suspension in rats after oral administration, with an absolute bioavailability of 26.67%. The new formulation was prepared using a modified two‐step method, which is widespread and easy to handle. Furthermore, the used excipients are considered generally recognized as safe (GRAS) for addition to food and/or drug products. Regard to industrial production aspects, the non‐aqueous SDEDDS have the chance to be exploited as drug delivery system in commercial products. Hence, the non‐aqueous SDEDDS could be applicable delivery system for hydrophobic compounds with low oral bioavailability. (i) The new non‐aqueous QT‐SDEDDS could spontaneously emulsify to oil‐in‐oil‐in‐water (O/O/W) double emulsions upon mild agitation by dilution in aqueous media; and (ii) after oral administration in rats, the non‐aqueous SDEDDS displayed an absolute bioavailability of 26.67%, which was 5.22 times higher than that of quercetin control suspension.

show abstract

“…The mixtures of NaC and quercetin are capable of reducing higher numbers of DPPH molecules when compared with free quercetin. This phenomenon was observed when encapsulating quercetin in polymer nanoparticles [44,45]. The absorbance of DPPH shows the lowest value when quercetin is added together with C NaC = 20 mM.…”

Section: Dpph Scavenging Activity Of Quercetinmentioning

confidence: 83%

Spectrometric study on the interaction of sodium cholate aggregates with quercetin

Zhou

Wang

2015

Colloids and Surfaces A: Physicochemical and Engineering Aspect

View full text Add to dashboard Cite

Quercetin-Loaded Lecithin/Chitosan Nanoparticles for Functional Food Applications

Cited by 145 publications

References 32 publications

Kaempferol loaded lecithin/chitosan nanoparticles: preparation, characterization, and their potential applications as a sustainable antifungal agent

Kaempferol loaded lecithin/chitosan nanoparticles: preparation, characterization, and their potential applications as a sustainable antifungal agent

Enhanced oral bioavailability of quercetin by a new non‐aqueous self‐double‐emulsifying drug delivery system

Spectrometric study on the interaction of sodium cholate aggregates with quercetin

Contact Info

Product

Resources

About