Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM)

Wang, Rong; Yang, Le; Shen, Li; Ye, Dongmei; Yang, Lihong; Liu, Qing‐Yan; Zhao, Zibo; Cai, Qing-Qing; Tan, Junzhen; Li, Xiuli

doi:10.12659/msm.908022

Cited by 100 publications

(70 citation statements)

References 39 publications

(39 reference statements)

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“…Prostate cancer stem cell↓; Breast cancer stem cells↓; Glioblastoma stem cells↓; Gastric cancer stem cells↓; Colorectal cancer stem cells↓; Pancreatic cancer stem↓…”

Section: Introductionmentioning

confidence: 99%

Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science

et al. 2019

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Traditional Chinese medicine (TCM) has been practiced for thousands of years and at the present time is widely accepted as an alternative treatment for cancer. In this review, we sought to summarize the molecular and cellular mechanisms underlying the chemopreventive and therapeutic activity of TCM, especially that of the Chinese herbal medicine‐derived phytochemicals curcumin, resveratrol, and berberine. Numerous genes have been reported to be involved when using TCM treatments and so we have selectively highlighted the role of a number of oncogene and tumor suppressor genes in TCM therapy. In addition, the impact of TCM treatment on DNA methylation, histone modification, and the regulation of noncoding RNAs is discussed. Furthermore, we have highlighted studies of TCM therapy that modulate the tumor microenvironment and eliminate cancer stem cells. The information compiled in this review will serve as a solid foundation to formulate hypotheses for future studies on TCM‐based cancer therapy.

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“…Prostate cancer stem cell↓; Breast cancer stem cells↓; Glioblastoma stem cells↓; Gastric cancer stem cells↓; Colorectal cancer stem cells↓; Pancreatic cancer stem↓…”

Section: Introductionmentioning

confidence: 99%

Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science

et al. 2019

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“…Quercetin is a plant-derived bioflavonoid with anticancer properties [153]. It suppresses the HSF1-dependent induction of the Hsps and shows antitumor effects in gastric, oral, lymphomas, prostate, colorectal, breast, pancreatic, liver, and lung cancer cell lines and various cancer stem cells [154][155][156][157]. Quercetin can act as a chemo-sensitizer, and it enhances the antitumor effects of first-line chemotherapeutic drugs such as doxorubicin, gemcitabine, 5-fluorouracil, and cisplatin [158,159].…”

Section: Anticancer Drugs Targeting Shspsmentioning

confidence: 99%

Small Heat Shock Proteins in Cancers: Functions and Therapeutic Potential for Cancer Therapy

Xiong

Tan

et al. 2020

IJMS

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Small heat shock proteins (sHSPs) are ubiquitous ATP-independent chaperones that play essential roles in response to cellular stresses and protein homeostasis. Investigations of sHSPs reveal that sHSPs are ubiquitously expressed in numerous types of tumors, and their expression is closely associated with cancer progression. sHSPs have been suggested to control a diverse range of cancer functions, including tumorigenesis, cell growth, apoptosis, metastasis, and chemoresistance, as well as regulation of cancer stem cell properties. Recent advances in the field indicate that some sHSPs have been validated as a powerful target in cancer therapy. In this review, we present and highlight current understanding, recent progress, and future challenges of sHSPs in cancer development and therapy.

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“…To promote apoptosis of cancer cells, QC decreases the expression of anti-apoptotic proteins, such as survivin, Bcl-xL, and Bcl-2, and increases the expression of the proapoptotic proteins, such as Bad and Bax, (15). Since it targets cancer cells and causes them to undergo apoptosis, this compound is a potential therapeutic for treating various cancers (17).…”

Section: Quercetinmentioning

confidence: 99%

“…Moreover, it inhibits the growth and invasive capacity of BrCa stem cells (MDA-MB-231) and downregulates various proteins, including aldehyde dehydrogenase 1A1, epithelial cell adhesion proteins, and others that are associated with the growth of BrCa cells. Therefore, by downregulating these proteins, the proliferation of BrCa cells is inhibited, showing that QC has anticancer properties (17). Thus, since QC promotes apoptosis of BrCa cells, it is likely to be effective in treating BrCa.…”

Section: Quercetinmentioning

confidence: 99%

shy Role of natural compounds in preventing and treating breast cancer

et al. 2020

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Breast cancer (BrCa) is the most commonly diagnosed cancer and the second leading cause of cancer-related death in women. Alarming increases in the cases quests for more effective treatment of BrCa. As most chemotherapeutic drugs are associated with drug resistance, cancer relapse, and side effects, scientists are turning to agents with more efficacy, such as natural compounds for treatment and prevention of BrCa. Selected natural compounds, substances derived from living organisms, promote apoptosis and inhibit metastasis, preventing cancer growth. As a result, these compounds have the potential to suppress BrCa progression, thus increasing patient survival rates and decreasing the number of BrCa-related deaths. In this review, we summarize natural compounds that have displayed, anti-cancer effects on BrCa cells in various studies. These natural compounds inhibit the development of BrCa, suppress the growth of cancer cells, and promote cell death. We conclude that natural compounds are efficient, effective and promising agents for treating BrCa other than therapeutic methods.

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Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM)

Cited by 100 publications

References 39 publications

Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science

Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science

Small Heat Shock Proteins in Cancers: Functions and Therapeutic Potential for Cancer Therapy

shy Role of natural compounds in preventing and treating breast cancer

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