Quercetin, Inflammation and Immunity

Li, Yao; Yao, Jiaying; Han, Cuiping; Yang, Jiaxin; Chaudhry, Maria Tabassum; Wang, Shengnan; Liu, Hongnan; Yin, Yulong

doi:10.3390/nu8030167

Cited by 1,226 publications

(784 citation statements)

References 72 publications

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“…The literature reported that rutin exerts intestinal anti-inflammatory effects in experimental models of colitis 42 and methyl gallate, one of the main compounds of the active fraction of the methanolic extract of the same family of Anacardiacceae, Lithrea molleoides, would explain the antiinflammatory activity observed in the model of ear edema. 43 Similarly, quercetin has been described as anti-inflammatory in several study models 44 and kaempferol reported as an effective compound against inflammation. 45 These data make it possible to attribute the anti-inflam matory activity of the MEPaL to the presence of gallic acid derivatives and flavonoids such as the derivatives of quercetin, myricetin and kaempferol.…”

Section: Resultsmentioning

confidence: 99%

Anti-inflammatory Activity of Methanolic Extract from Pistacia atlantica Desf. Leaves

Amri¹,

Zekhnini²,

Bouhaimi³

et al. 2017

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Introduction:The extracts of the Pistacia species are known for their anti-inflammatory activity, including fruits and oil of P. atlantica. However, the inflammatory effect of the methanolic extract of P. atlantica leaves has not been studied. This work aimed at assessing the antiinflammatory and antioxidant activities of P. atlantica leaves extract in relation to phytochemical studies of flavonoids. Methods: The extract was obtained using sonication of leaves powder in 80 % methanol. The analysis of phenolic compounds was carried out using thin-layer chromatography (TLC). The antioxidant activity was evaluated using DPPH, ABTS and FRAP assays. The anti-inflammatory activity was determined by the reduction of carrageenaninduced hind paw edema in mice. Results: The TLC revealed 3 glycosylated flavonoids and gallic acid derivatives. The flavonoids identified corresponded to rutin, quercetrin and other heterosides of quercetin, kaempferol and myricetin. Total phenolics and flavonoids contents were comparable for the male and female trees. The antioxidant activity did not show a significative difference between the two sexes, except for that evaluated by the FRAP assay which was significantly greater for the male tree leaves extract. The leaves extract permitted significative reduction of the edema at h3 and 6 in a dose-dependent manner (100 and 250 mg/kg), while diclofenac used as control reduced the edema at h 1.5. This difference could be explained by the pharmacokinetic and pharmacodynamic properties of diclofenac and P. atlantica leaves compounds. Conclusion: P. atlantica has a strong anti-inflammatory activity and constitutes a potential source for the development of new treatments. Key words: Antioxidant activity, Flavonoids, Methanolic extract, Plantar edema, TLC. Oukacha ulcers.4 This has led to the search for alternative treatments. In this regard, secondary metabolites of various medicinal plants have been shown to be effective in the treatment of inflammation and pain.5 Among these plants, the species of Pistacia genus are of interest. Indeed, this genus includes 11 species that are widely distributed on the different continents of the terrestrial globe. They are found in temperate forests, tropical hardwoods and boreal conifers.6 P. atlantica is one of the most widespread wildlife species. It is the most characteristic plant of the arid and semi-arid zones of the northern part of Africa.7 In traditional medicine, P. atlantica is used for the treatment of pain and other conditions such as upper abdominal discomfort, dyspepsia and peptic ulcer.8 Several studies reported that the different parts of the plant as fruits, galls and oil, have biological effects including anti-inflammatory activities.9-12 However, as far as we know, no work has been devoted to the study of the anti-inflammatory effect of the methanolic extract of P. atlantica leaves (MEPaL). Thus, this study aimed at assessing the anti-inflammatory activity of DPPH scavenging activityThe antiradical power of substances was measured ...

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Section: Resultsmentioning

confidence: 99%

Anti-inflammatory Activity of Methanolic Extract from Pistacia atlantica Desf. Leaves

Amri¹,

Zekhnini²,

Bouhaimi³

et al. 2017

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“…Quercetin is a further flavonoid with a wide range of biological properties. Recent studies have associated quercetin to strong anti-inflammatory, anti-viral and anti-carcinogenic activities along with attenuation of lipid peroxidation [47]. Moreover, this polyphenol was shown to act as mast cell inhibitor to treat allergic and inflammatory diseases [48].…”

Section: Discussionmentioning

confidence: 99%

Epigenetics and Nutrition

Raganelli¹

2018

MOJFPT

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In the last few years, the idea of food and nutrition has undergone radical changes. The paradigm defining food as a simple source of energy and body mass has evolved in a novel concept, in which nutrients can exert specific functions directly linked to human health. Several edibles contain biological active compounds that influence cellular, metabolic and physiologic processes. A variety of dietary compounds have been associated with specific effects and mechanisms of action, often involving epigenetic modifications and gene expression changes. DNA methylation, histone modifications and the activity of non-coding RNAs control chromatin condensation state, allowing the interaction of DNA with transcription factors required for transcriptional activation. Some metabolites act as substrates of key chromatin remodeling factors or compete with other substrates, influencing their catalytic activity. The quantity and quality of macronutrients assumed by diet offers a possible mechanism of interaction between the body and its environment. A number of biological compounds are known to interact with the epigenome. Folic acid, methionine, choline and other B group vitamins are an important source of one-carbon groups required for methylation of histone proteins and non-histone chromatin remodeling factors. Other compounds like polyphenols, including resveratrol, curcumin and quercetin exert a multitude of biological activities. Furthermore, these compounds can influence DNA methyltransferases, the enzymes responsible for DNA methylation. Dietary interventions aimed to maximize potential health benefits derived from nutrition have shown that dietary regimens can be very effective for prevention and treatment of several diseases. Calorie restriction, protein restriction, fast mimicking diets or time restricted feeding have shown to have significant effects on health. Food quality is crucial for the activity of biological compounds and their potential health benefits. Diets rich in animal-derived proteins are associated with higher rates of mortality compared to diets based on plant-derived proteins.

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“…9 Literature survey suggested anti-inflammato ry activity of quercetin, coumarin, caffeic acid and chlorogenic acid were evident in in vitro and in vivo systems. [18][19][20][21] However, further investigations are essential to find out the bioactive components involved in the antiinflammatory activity. Secondary lesions were not much observed in the rat groups.…”

Section: Adjuvant Induced Arthritis Modelmentioning

confidence: 99%

Evaluation of anti-inflammatory effect of beetroot extract in animal models

Adhikari

Saha²,

Indu

et al. 2017

Int J Basic Clin Pharmacol

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Background: Inflammation is complex biological response of body tissues to foreign particles or pathogens. However, adverse effects of anti-inflammatory drugs, necessitate the search for a novel compound from herbal origin. Beta vulgaris rubra or red beetroot, a vegetable plant, is known to possess various beneficial effects. Present study aimed to evaluate the anti inflammatory effect of beet roots in animal models.Methods: Carrageenan-induced and Complete Freund’s adjuvant-induced rat paw edema model were used to assess the acute and chronic anti- inflammatory potential of the Beetroot as compared to standard drug, Diclofenac Sodium.Results: Oral administration of Beetroot extract showed carrageenan-induced rat paw edema inhibition by 26.9%, 34.6% and 50% for beetroot 100mg/Kg, 200mg/Kg and 400mg/Kg, respectively, at the end of four hours. In vivo results noted that percentage inhibition of paw volume and ankle diameter of the Complete Freund’s adjuvant-induced rats were significantly higher for the groups consuming 100 and 200mg/Kg Beetroot extracts. Paw volume of the rats in these two groups reduced by 35% and 30% respectively as compared to the control.Conclusions: Thus, beetroot was found to possess anti-inflammatory property in animals. Further investigations are essential to validate the bioactive components responsible for this property.

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Quercetin, Inflammation and Immunity

Cited by 1,226 publications

References 72 publications

Anti-inflammatory Activity of Methanolic Extract from Pistacia atlantica Desf. Leaves

Anti-inflammatory Activity of Methanolic Extract from Pistacia atlantica Desf. Leaves

Epigenetics and Nutrition

Evaluation of anti-inflammatory effect of beetroot extract in animal models

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