Quercetin induces an immunoregulatory phenotype in maturing human dendritic cells

Michalski, Julia; Deinzer, Andrea; Stich, Lena; Zinser, Elisabeth; Steinkasserer, Alexander; Knippertz, Ilka

doi:10.1016/j.imbio.2020.151929

Cited by 26 publications

(26 citation statements)

References 69 publications

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“…Interestingly, quercetin inhibits tyrosine phosphorylation of EGFR and NF-κB pathways resulted in the suppression of mucin synthesis in rat lungs and reduction of MUC5AC in human airway epithelial NCI-H292 cells, and hence it reduces the mucus production and difficulty in breathing (Yang et al 2012 ). Furthermore, quercetin exerts immunomodulatory effects on human dendritic cells (DCs) by direct the binding of aryl hydrocarbon receptor to CD83 promoter causing down expression of CD83 (Michalski et al 2020 ). This impairs T-cell activation and migration of matured DCs (Michalski et al 2020 ).…”

Section: Immunomodulatory and Anti-inflammatory Activities Of Flavonoidsmentioning

confidence: 99%

“…Furthermore, quercetin exerts immunomodulatory effects on human dendritic cells (DCs) by direct the binding of aryl hydrocarbon receptor to CD83 promoter causing down expression of CD83 (Michalski et al 2020 ). This impairs T-cell activation and migration of matured DCs (Michalski et al 2020 ).…”

Section: Immunomodulatory and Anti-inflammatory Activities Of Flavonoidsmentioning

confidence: 99%

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Flavonoids are promising safe therapy against COVID-19

et al. 2021

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Flavonoids are a class of phenolic natural products, well-identified in traditional and modern medicines in the treatment of several diseases including viral infection. Flavonoids showed potential inhibitory activity against coronaviruses including the current pandemic outbreak caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and designated as COVID-19. Here, we have collected all data related to the potential inhibitory mechanisms of flavonoids against SARS-CoV-2 infection and their significant immunomodulatory activities. The data were mapped and compared to elect major flavonoids with a promising role in the current pandemic. Further, we have linked the global existence of flavonoids in medicinal plants and their role in protection against COVID-19. Computational analysis predicted that flavonoids can exhibit potential inhibitory activity against SARS-CoV-2 by binding to essential viral targets required in virus entry and/ or replication. Flavonoids also showed excellent immunomodulatory and anti-inflammatory activities including the inhibition of various inflammatory cytokines. Further, flavonoids showed significant ability to reduce the exacerbation of COVID-19 in the case of obesity via promoting lipids metabolism. Moreover, flavonoids exhibit a high safety profile, suitable bioavailability, and no significant adverse effects. For instance, plants rich in flavonoids are globally distributed and can offer great protection from COVID-19. The data described in this study strongly highlighted that flavonoids particularly quercetin and luteolin can exhibit promising multi-target activity against SARS-CoV-2, which promote their use in the current and expected future outbreaks. Therefore, a regimen of flavonoid-rich plants can be recommended to supplement a sufficient amount of flavonoids for the protection and treatment from SARS-CoV-2 infection.

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Section: Immunomodulatory and Anti-inflammatory Activities Of Flavonoidsmentioning

confidence: 99%

Section: Immunomodulatory and Anti-inflammatory Activities Of Flavonoidsmentioning

confidence: 99%

Flavonoids are promising safe therapy against COVID-19

et al. 2021

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“…Here we demonstrated strong inhibitory effect against IL-8 production by epithelial cells, which maybe a novel mechanism of quercetin's anti-inflammatory activity. Michalski et al [29] showed that quercetin reduced also a production of other pro-inflammatory cytokine IL-12p70 by LPS-stimulated dendritic cells, which resulted in quenching of inflammation.…”

Section: Preparation * Action 6 H Action 24 H Control/significance 6 mentioning

confidence: 99%

Phenolic and Non-Polar Fractions of the Extracts from Fruits, Leaves, and Twigs of Elaeagnus rhamnoides (L.) A. Nelson—The Implications for Human Barrier Cells

et al. 2020

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Biological potential of plant extracts are widely described. Because their oral or topical administration is usually recommended, intestinal mucous and skin are the first surfaces exposed to such preparations. Therefore, we asked the question whether phenolic and non-polar fractions of the extracts from fruits, twigs, and leaves of sea buckthorn (Elaeagnus rhamnoides (L.) A. Nelson) would be able to modulate the functions of human physiological barrier. The study was carried on caucasian colon epithelial-like Caco-2 cells and human foreskin fibroblasts HFF-1 line. Cell secretory activity (ELISA), the expression of cell surface molecules (flow cytometry), cell migration during wound healing in vitro (scratch assay) were assessed. It was demonstrated for the first time, that sea buckthorn extracts can improve intestinal and skin barrier by increasing of ICAM-1 expression on colon epithelial cells and intensification of IL-8 production by fibroblasts. On the other hand, an inhibition of fibroblasts migration in the presence of those preparations was noted. Therefore, greater attention should be paid on precise description of plant extracts effect depended on target cells and their role to give adequate recommendations for such preparations use.

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“…In addition to this, a very recent study described the aryl hydrocarbon receptor (AhR) to be involved in the transcriptional regulation of the CD83 molecule (8). Bioinformatics analyses revealed two potential AhR-binding motifs (XRE) within the URE and the MP-261 of the human CD83 promoter.…”

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confidence: 99%

“…Following activation of AhR by the flavonoid quercetin, AhR was demonstrated to directly bind to the P-510 in human DCs, accompanied by a strong downregulation of CD83 mRNA and protein expression. Regarding the mode of action the authors hypothesize that the negative control of CD83 transcription by AhR might be either due to the association of AhR with NF K B, thereby modulating its activity, or due to a steric hindrance of adjacent AhR affecting the binding of NF K B to its site (8).…”

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confidence: 99%

The CD83 Molecule – An Important Immune Checkpoint

et al. 2020

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The CD83 molecule has been identified to be expressed on numerous activated immune cells, including B and T lymphocytes, monocytes, dendritic cells, microglia, and neutrophils. Both isoforms of CD83, the membrane-bound as well as its soluble form are topic of intensive research investigations. Several studies revealed that CD83 is not a typical co-stimulatory molecule, but rather plays a critical role in controlling and resolving immune responses. Moreover, CD83 is an essential factor during the differentiation of T and B lymphocytes, and the development and maintenance of tolerance. The identification of its interaction partners as well as signaling pathways have been an enigma for the last decades. Here, we report the latest data on the expression, structure, and the signaling partners of CD83. In addition, we review the regulatory functions of CD83, including its striking modulatory potential to maintain the balance between tolerance versus inflammation during homeostasis or pathologies. These immunomodulatory properties of CD83 emphasize its exceptional therapeutic potential, which has been documented in specific preclinical disease models.

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Quercetin induces an immunoregulatory phenotype in maturing human dendritic cells

Cited by 26 publications

References 69 publications

Flavonoids are promising safe therapy against COVID-19

Flavonoids are promising safe therapy against COVID-19

Phenolic and Non-Polar Fractions of the Extracts from Fruits, Leaves, and Twigs of Elaeagnus rhamnoides (L.) A. Nelson—The Implications for Human Barrier Cells

The CD83 Molecule – An Important Immune Checkpoint

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