Quercetin‐Induced miR‐369‐3p Suppresses Chronic Inflammatory Response Targeting C/EBP‐β

Galleggiante, Vanessa; Santis, Stefania De; Liso, Marina; Verna, Giulio; Sommella, Eduardo; Mastronardi, Mauro; Campiglia, Pietro; Chieppa, Marcello; Serino, Grazia

doi:10.1002/mnfr.201801390

Cited by 46 publications

(35 citation statements)

References 64 publications

(82 reference statements)

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“…www.nature.com/scientificreports/ quercetin exposure, we confirm the protective role of miR-369-3p in DCs stimulated by LPS in suppressing the LPS-induced inflammatory response 11 .…”

supporting

confidence: 73%

“…In our recent study, we identified a specific signature of 113 miRNAs that were differentially regulated in LPS-stimulated BMDCs after quercetin exposure, along with their candidate target genes. Among these miRNAs, we mechanistically demonstrated that the induction of miR-369-3p is able to downregulate the inflammatory response induced by LPS, mimicking the effect of quercetin exposure 11 .…”

Section: Discussionmentioning

confidence: 91%

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miR-369-3p modulates inducible nitric oxide synthase and is involved in regulation of chronic inflammatory response

Scalavino

Liso

Cavalcanti

et al. 2020

Sci Rep

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Dendritic cells are the most important antigen-presenting cells that link the innate and acquired immune system. In our previous study, we identified that the upregulation of miR-369-3p suppresses the LPS-induced inflammatory response, reducing C/EBP-β, TNFα and IL-6 production. With the aim of gaining further insight into the biological function of miR-369-3p during acute inflammatory response, in the present study we identified novel gene targets of miR-369-3p and demonstrated the suppressive ability of these genes on the inflammatory dendritic cells. Bioinformatic analyses revealed that iNOS is a potential target of miR-369-3p. We demonstrated that the ectopic induction of miR-369-3p markedly reduced iNOS mRNA and protein as well as NO production. Moreover, we found that the upregulation of miR-369-3p decreased the release of TNFα, IL-6, IL-12, IL-1α, IL-1β in response to LPS, and increased the production of anti-inflammatory cytokines such as IL-10 and IL-1RA. In addition, LPS-induced nuclear translocation of NF-kB was inhibited by miR-369-3p. Levels of miR-369-3p were decreased in human inflamed regions of human intestine obtained from IBD patients. Our results provide novel additional information on miR-369-3p as a potential core of the signaling regulating the inflammatory response. These findings suggest that miR-369-3p should be considered as a potential target for the future development of new molecular therapeutic approaches.

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“…www.nature.com/scientificreports/ quercetin exposure, we confirm the protective role of miR-369-3p in DCs stimulated by LPS in suppressing the LPS-induced inflammatory response 11 .…”

supporting

confidence: 73%

Section: Discussionmentioning

confidence: 91%

miR-369-3p modulates inducible nitric oxide synthase and is involved in regulation of chronic inflammatory response

Scalavino

Liso

Cavalcanti

et al. 2020

Sci Rep

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“…Que may reduce infection ( Li et al, 2016 ), hepatic lipemic-oxidative damage ( Cui et al, 2013 ) ( Zhang et al, 2016b ), and antioxidant risk ( Xu et al, 2019 ). In addition, Que is known to exert a modulating action on immunity ( Galleggiante et al, 2019 ). As regards its mechanism of action, in some cell lines Que was able to inhibit the production of TNF in macrophages ( Tang et al, 2019 ), IL-8 in A549 lung cells induced by lipopolysaccharide (LPS) ( Geraets et al, 2007 ), and TNF-α and IL-1α mRNA levels in glial cells, causing a decrease in neuronal cell death induced by microglial activation ( Li et al, 2016 ).…”

Section: Natural Compounds Enhancing Sirt1 Expression and Activitymentioning

confidence: 99%

SIRT1 Activation by Natural Phytochemicals: An Overview

et al. 2020

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Sirtuins are class III histone deacetylases, whose enzymatic activity is dependent on NAD + as a cofactor. Sirtuins are reported to modulate numerous activities by controlling gene expression, DNA repair, metabolism, oxidative stress response, mitochondrial function, and biogenesis. Deregulation of their expression and/or action may lead to tissue-specific degenerative events involved in the development of several human pathologies, including cancer, neurodegeneration, and cardiovascular disease. The most studied member of this class of enzymes is sirtuin 1 (SIRT1), whose expression is associated with increasing insulin sensitivity. SIRT1 has been implicated in both tumorigenic and anticancer processes, and is reported to regulate essential metabolic pathways, suggesting that its activation might be beneficial against disorders of the metabolism. Via regulation of p53 deacetylation and modulation of autophagy, SIRT1 is implicated in cellular response to caloric restriction and lifespan extension. In recent years, scientific interest focusing on the identification of SIRT1 modulators has led to the discovery of novel small molecules targeting SIRT1 activity. This review will examine compounds of natural origin recently found to upregulate SIRT1 activity, such as polyphenolic products in fruits, vegetables, and plants including resveratrol, fisetin, quercetin, and curcumin. We will also discuss the potential therapeutic effects of these natural compounds in the prevention and treatment of human disorders, with particular emphasis on their metabolic impact.

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“…Furthermore, they showed that the expression of pro-inflammatory cytokines is positively regulated by C/EBP-β and is a direct target of miR-223 [91]. Moreover, in bone marrow-derived DCs and intestinal DCs, the regulation of C/EBP-β by miR-369-3p suppresses the chronic inflammatory response [100].…”

Section: Mirnas In Dc-mediated Intestinal Diseasesmentioning

confidence: 99%

Role of microRNAs in the Regulation of Dendritic Cell Generation and Function

Scalavino¹,

Liso²,

Serino³

2020

IJMS

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Dendritic cells (DCs) are antigen-presenting cells with a key role in immune responses. They act as a link between the innate and adaptive systems and they can induce and maintain immunologic tolerance. DCs are subdivided into conventional and plasmacytoid DCs. These cell subsets originate from the same bone marrow precursors and their differentiation process is determined by several extrinsic and intrinsic factors, such as cytokines, transcription factors, and miRNAs. miRNAs are small non-coding RNAs that play a crucial role in modulating physiological and pathological processes mediated by DCs. miRNA deregulation affects many inflammatory conditions and diseases. The aim of this review was to underline the importance of miRNAs in inflammatory processes mediated by DCs in physiological and pathological conditions and to highlight their potential application for future therapies.

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Quercetin‐Induced miR‐369‐3p Suppresses Chronic Inflammatory Response Targeting C/EBP‐β

Cited by 46 publications

References 64 publications

miR-369-3p modulates inducible nitric oxide synthase and is involved in regulation of chronic inflammatory response

miR-369-3p modulates inducible nitric oxide synthase and is involved in regulation of chronic inflammatory response

SIRT1 Activation by Natural Phytochemicals: An Overview

Role of microRNAs in the Regulation of Dendritic Cell Generation and Function

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