Quercetin in Tonglong Qibi decoction ameliorates testosterone‐induced benign prostatic hyperplasia in rats by regulating Nrf2 signalling pathways and oxidative stress
Abstract:Benign prostatic hyperplasia (BPH) is a common urological disease in older males. Existing pharmacotherapy shows several side effects, and the exploration of new therapeutic strategies is of high significance. Tonglong Qibi (TQ) decoction was proved to ameliorate BPH, while the underlying mechanisms are still unclear. In the current study, we explored the anti-BPH effects of TQ in vivo and identified its main therapeutic component and the underlying mechanisms in vitro. We demonstrated that TQ mitigated BPH in… Show more
“…This author suggested that the functional component of Tonglong Qibi decoction was quercetin, which inhibited the proliferation factor and induced apoptosis in RWPE-1 cells. 52 Therefore, it is suggested that components other than the previously reported triterpenes in CAA may also affect androgen receptor signaling and the PI3K/Akt pathway. However, the identification of biologically active compounds of CAA from the results of this experiment is still limited.…”
Centella asiatica (L.) Urban (C. asiatica) is a traditional herbal medicine that has been used for wound healing and anti-inflammation since ancient times. Various biological effects of C. asiatica ethanolic...
“…This author suggested that the functional component of Tonglong Qibi decoction was quercetin, which inhibited the proliferation factor and induced apoptosis in RWPE-1 cells. 52 Therefore, it is suggested that components other than the previously reported triterpenes in CAA may also affect androgen receptor signaling and the PI3K/Akt pathway. However, the identification of biologically active compounds of CAA from the results of this experiment is still limited.…”
Centella asiatica (L.) Urban (C. asiatica) is a traditional herbal medicine that has been used for wound healing and anti-inflammation since ancient times. Various biological effects of C. asiatica ethanolic...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.